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<datestamp>2018-01-11</datestamp>
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<title lang=en>Antimalarial activity of simalikalactone E, a new quassinoid from quassia amara L (simaroubaceae)</title>
<creator>Cachet, N.</creator>
<creator>Hoakwie, Franciane</creator>
<creator>Bertani, Stéphanie</creator>
<creator>Bourdy, Geneviève</creator>
<creator>Deharo, Eric</creator>
<creator>Stien, Didier</creator>
<creator>Houel, Emeline</creator>
<creator>Gornitzka, Heinz</creator>
<creator>Fillaux, Judith</creator>
<creator>Chevalley, S.</creator>
<creator>Valentin, Alexis</creator>
<creator>Jullian, V.</creator>
<contributor>UMR 152, UPS, Laboratoire de Pharmacochimie des Substances Naturelles et Pharmacophores Redox ; Université de Toulouse</contributor>
<contributor>UMR 152 ; Institut de Recherche pour le Développement (IRD)</contributor>
<contributor>USM 0307, Laboratoire de Parasitologie Comparée et Modèles Expérimentaux ; Muséum National d'Histoire Naturelle (MNHN)</contributor>
<contributor>Ecologie des forêts de Guyane (ECOFOG) ; Centre de Coopération Internationale en Recherche Agronomique pour le Développement (CIRAD) - Institut National de la Recherche Agronomique (INRA) - Université des Antilles et de la Guyane (UAG) - AgroParisTech - Centre National de la Recherche Scientifique (CNRS)</contributor>
<contributor>LCC, UPR 8241 ; Centre National de la Recherche Scientifique (CNRS)</contributor>
<contributor>Service de Parasitologie-Mycologie, CHU Rangueil ; Centre Hospitalier Universitaire de Toulouse</contributor>
<description> </description>
<source>ISSN: 0066-4804</source>
<source>EISSN: 1098-6596</source>
<source>Antimicrobial Agents and Chemotherapy</source>
<publisher>American Society for Microbiology</publisher>
<identifier>hal-01032126</identifier>
<identifier>https://hal.archives-ouvertes.fr/hal-01032126</identifier>
<source>https://hal.archives-ouvertes.fr/hal-01032126</source>
<source>Antimicrobial Agents and Chemotherapy, American Society for Microbiology, 2009, 53 (10), pp.4393-4398. 〈10.1128/AAC.00951-09〉</source>
<identifier>DOI : 10.1128/AAC.00951-09</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1128/AAC.00951-09</relation>
<language>en</language>
<subject lang=en> </subject>
<subject>[SDV.SA] Life Sciences [q-bio]/Agricultural sciences</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>We report the isolation and identification of a new quassinoid named simalikalactone E (SkE), extracted from a widely used Amazonian antimalarial remedy made out of Quassia amara L. (Simaroubaceae) leaves. This new molecule inhibited the growth of Plasmodium falciparum cultured in vitro by 50%, in the concentration range from 24 to 68 nM, independently of the strain sensitivity to chloroquine. We also showed that this compound was able to decrease gametocytemia with a 50% inhibitory concentration sevenfold lower than that of primaquine. SkE was found to be less toxic than simalikalactone D (SkD), another antimalarial quassinoid from Q. amara, and its cytotoxicity on mammalian cells was dependent on the cell line, displaying a good selectivity index when tested on nontumorogenic cells. In vivo, SkE inhibited murine malaria growth of Plasmodium vinckei petteri by 50% at 1 and 0.5 mg/kg of body weight/day, by the oral or intraperitoneal routes, respectively. The contribution of quassinoids as a source of antimalarial molecules needs therefore to be reconsidered.</description>
<date>2009</date>
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