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<publisher>HAL CCSD</publisher>
<title lang=en>Leptin receptor gene in the European sea bass (Dicentrarchus labrax): cloning, phylogeny, tissue distribution and neuroanatomical organization</title>
<creator>Escobar, Sebastián</creator>
<creator>Rocha, Ana</creator>
<creator>Felip, Alicia</creator>
<creator>Carrillo, Manuel</creator>
<creator>Zanuy, Silvia</creator>
<creator>Kah, Olivier</creator>
<creator>Servili, Arianna</creator>
<contributor>Instituto de Acuicultura de Torre de la Sal ; Consejo Superior de Investigaciones Científicas [Spain] (CSIC)</contributor>
<contributor>Institut de recherche, santé, environnement et travail [Rennes] (Irset) ; Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor>
<contributor>We would like to thank the Animal Husbandry Service at IATS for technical assistance and sampling with the animals. This research was supported by UE project FP7-222719-1 (LIFECYCLE), project PROMETEO/11/2014/051 (REPROBASS) from the Valencian Regional Government and CSD2007-00002 (AQUAGENOMICS) from the Ministry of Science and Innovation (MICINN), Spain. </contributor>
<description>International audience</description>
<source>ISSN: 0016-6480</source>
<source>EISSN: 1095-6840</source>
<source>General and Comparative Endocrinology</source>
<publisher>Elsevier</publisher>
<identifier>hal-01290500</identifier>
<identifier>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01290500</identifier>
<identifier>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01290500/document</identifier>
<identifier>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01290500/file/Leptin%20receptor%20gene%20in%20the%20European%20sea%20bass%20postprint.pdf</identifier>
<source>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01290500</source>
<source>General and Comparative Endocrinology, Elsevier, 2016, 229, pp.100-111. 〈10.1016/j.ygcen.2016.03.017〉</source>
<identifier>DOI : 10.1016/j.ygcen.2016.03.017</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1016/j.ygcen.2016.03.017</relation>
<identifier>PUBMED : 26979276</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/26979276</relation>
<language>en</language>
<subject lang=en>Central nervous system</subject>
<subject lang=en> Energy homeostasis</subject>
<subject lang=en> Food intake</subject>
<subject lang=en> Reproduction</subject>
<subject lang=en> Teleost</subject>
<subject>[SDV.BA.ZV] Life Sciences [q-bio]/Animal biology/Vertebrate Zoology</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>In this study, we report the cloning of three transcripts for leptin receptor in the European sea bass, a marine teleost of economic interest. The two shortest variants, generated by different splice sites, encode all functional extracellular and intracellular domains but missed the transmembrane domain. The resulting proteins are therefore potential soluble binding proteins for leptin. The longest transcript (3605 bp), termed sblepr, includes all the essential domains for binding and transduction of the signal. Thus, it is proposed as the ortholog for the human LEPR gene, the main responsible for leptin signalling. Phylogenetic analysis shows the sblepr clustered within the teleost leptin receptor group in 100% of the bootstrap replicates. The neuroanatomical localization of sblepr expressing cells has been assessed by in situ hybridization in brains of sea bass of both sexes during their first sexual maturation. At histological level, the distribution pattern of sblepr expressing cells in the brain shows no clear differences regarding sex or reproductive season. Transcripts of the sblepr have a widespread distribution throughout the forebrain and midbrain until the caudal portion of the hypothalamus. A high hybridization signal is detected in the telencephalon, preoptic area, medial basal and caudal hypothalamus and in the pituitary gland. In a more caudal region, sblepr expressing cells are identified in the longitudinal torus. The expression pattern observed for sblepr suggests that in sea bass, leptin is very likely to be involved in the control of food intake, energy reserves and reproduction</description>
<date>2016</date>
<contributor>European Project : 222719, EC:FP7:KBBE, FP7-KBBE-2007-2A, LIFECYCLE(2009)</contributor>
<relation>info:eu-repo/grantAgreement/EC/FP7/222719/EU/Building a biological knowledge-base on fish lifecycles for competitive, sustainable European aquaculture/LIFECYCLE</relation>
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