untitled
<OAI-PMH schemaLocation=http://www.openarchives.org/OAI/2.0/ http://www.openarchives.org/OAI/2.0/OAI-PMH.xsd>
<responseDate>2018-01-15T18:30:09Z</responseDate>
<request identifier=oai:HAL:hal-01142062v1 verb=GetRecord metadataPrefix=oai_dc>http://api.archives-ouvertes.fr/oai/hal/</request>
<GetRecord>
<record>
<header>
<identifier>oai:HAL:hal-01142062v1</identifier>
<datestamp>2017-12-21</datestamp>
<setSpec>type:ART</setSpec>
<setSpec>subject:sdv</setSpec>
<setSpec>collection:UNIV-RENNES1</setSpec>
<setSpec>collection:UNIV-AG</setSpec>
<setSpec>collection:IRSET</setSpec>
<setSpec>collection:IRSET-NEED</setSpec>
<setSpec>collection:BIOSIT</setSpec>
<setSpec>collection:IFR140</setSpec>
<setSpec>collection:UR1-UFR-SVE</setSpec>
<setSpec>collection:STATS-UR1</setSpec>
<setSpec>collection:UR1-SDV</setSpec>
<setSpec>collection:UR1-HAL</setSpec>
<setSpec>collection:EHESP</setSpec>
<setSpec>collection:USPC</setSpec>
<setSpec>collection:UNIV-ANGERS</setSpec>
</header>
<metadata><dc>
<publisher>HAL CCSD</publisher>
<title lang=en>Local modulation of steroid action: rapid control of enzymatic activity.</title>
<creator>Charlier, Thierry D</creator>
<creator>Cornil, Charlotte A</creator>
<creator>Patte-Mensah, Christine</creator>
<creator>Meyer, Laurence</creator>
<creator>Mensah-Nyagan, A Guy</creator>
<creator>Balthazart, Jacques</creator>
<contributor>Institut de recherche, santé, environnement et travail [Rennes] (Irset) ; Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor>
<contributor>Ohio University, Athens</contributor>
<contributor>GIGA Neurosciences, Research Group in Behavioral Neuroendocrinology ; Université de Liège</contributor>
<contributor>Biopathologie de la Myéline, Neuroprotection et Stratégies Thérapeutiques ; Institut National de la Santé et de la Recherche Médicale (INSERM) - Faculté de Médecine</contributor>
<contributor>Some of these data were obtained thanks to the Fonds Leon Frederic (ULg, Belgium) and FNRS-FRS to TDC and grant from NIH/NIMH (R01MH50388) to GF Ball and JB. TDC was a F.R.S.-FNRS Post-doctoral Researcher. CAC is a F.R.S.-FNRS Research Associate.</contributor>
<description>International audience</description>
<source>ISSN: 1662-4548</source>
<source>EISSN: 1662-453X</source>
<source>Frontiers in Neuroscience</source>
<publisher>Frontiers</publisher>
<identifier>hal-01142062</identifier>
<identifier>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01142062</identifier>
<identifier>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01142062/document</identifier>
<identifier>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01142062/file/fnins-09-00083.pdf</identifier>
<source>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01142062</source>
<source>Frontiers in Neuroscience, Frontiers, 2014, 9, pp.83. 〈10.3389/fnins.2015.00083〉</source>
<identifier>PUBMED : 25852459</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/25852459</relation>
<identifier>DOI : 10.3389/fnins.2015.00083</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.3389/fnins.2015.00083</relation>
<identifier>PUBMEDCENTRAL : PMC4365721</identifier>
<language>en</language>
<subject lang=en>phosphorylation</subject>
<subject lang=en>neurosteroidogenesis</subject>
<subject lang=en>catechol-estrogens</subject>
<subject lang=en>17β-estradiol</subject>
<subject lang=en>hypothalamus</subject>
<subject lang=en>aromatase</subject>
<subject>[SDV] Life Sciences [q-bio]</subject>
<subject>[SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>Estrogens can induce rapid, short-lived physiological and behavioral responses, in addition to their slow, but long-term, effects at the transcriptional level. To be functionally relevant, these effects should be associated with rapid modulations of estrogens concentrations. 17β-estradiol is synthesized by the enzyme aromatase, using testosterone as a substrate, but can also be degraded into catechol-estrogens via hydroxylation by the same enzyme, leading to an increase or decrease in estrogens concentration, respectively. The first evidence that aromatase activity (AA) can be rapidly modulated came from experiments performed in Japanese quail hypothalamus homogenates. This rapid modulation is triggered by calcium-dependent phosphorylations and was confirmed in other tissues and species. The mechanisms controlling the phosphorylation status, the targeted amino acid residues and the reversibility seem to vary depending of the tissues and is discussed in this review. We currently do not know whether the phosphorylation of the same amino acid affects both aromatase and/or hydroxylase activities or whether these residues are different. These processes provide a new general mechanism by which local estrogen concentration can be rapidly altered in the brain and other tissues.</description>
<rights>http://creativecommons.org/licenses/by/</rights>
<date>2014-11-30</date>
</dc>
</metadata>
</record>
</GetRecord>
</OAI-PMH>
