untitled
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<identifier>oai:HAL:hal-00717073v1</identifier>
<datestamp>2017-12-21</datestamp>
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<setSpec>subject:sdv</setSpec>
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<publisher>HAL CCSD</publisher>
<title lang=en>Litomosoides carinii infection in cotton-rats: evolution of microfilaraemia before and after treatment with diethylcarbamazine and suramin.</title>
<creator>Carme, Bernard</creator>
<creator>Lenoble, D. R.</creator>
<creator>Smith, M.</creator>
<creator>Pontal, P.</creator>
<creator>Gentilini, M.</creator>
<contributor>Epidémiologie des parasitoses et mycoses tropicales ; Université des Antilles et de la Guyane (UAG) - Institut National de la Santé et de la Recherche Médicale (INSERM)</contributor>
<description>International audience</description>
<source>ISSN: 0035-9203</source>
<source>Transactions of The Royal Society of Tropical Medicine and Hygiene</source>
<publisher>Oxford University Press (OUP)</publisher>
<identifier>hal-00717073</identifier>
<identifier>https://hal.univ-antilles.fr/hal-00717073</identifier>
<source>https://hal.univ-antilles.fr/hal-00717073</source>
<source>Transactions of The Royal Society of Tropical Medicine and Hygiene, Oxford University Press (OUP), 1981, 75 (3), pp.418-20</source>
<identifier>PUBMED : 7034313</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/7034313</relation>
<language>en</language>
<subject>[SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>The activity of diethylcarbamazine (DEC) and suramin (S) on Litomosoides carinii filariasis was assessed by the study of microfilaraemia in 30 cotton-rats (Sigmodon hispidus). DEC (per os) and S (injected subcutaneously) were administered alone or in combination, at doses of 50 mg/kg/day for five consecutive days. 15 rats were treated at day 91 after infection and 15 others at day 184. The immediate but temporary efficacy observed with DEC was in contrast to the delayed and long-lasting effect of S. With combined therapy there was neither antagonism nor synergism. The demonstration of an apparently smaller reduction of parasitaemia in the rats treated with DEC before the plateau phase of the microfilaraemia was consistent with the lack of action of this drug on microfilariae outside the blood system.</description>
<date>1981</date>
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