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<datestamp>2017-12-21</datestamp>
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<title lang=en>Meiotic Genes Are Enriched in Regions of Reduced Archaic Ancestry</title>
<creator>Jégou, B.</creator>
<creator>Sankararaman, S.</creator>
<creator>Rolland, A. D.</creator>
<creator>Reich, D.</creator>
<creator>Chalmel, F.</creator>
<contributor>Institut de recherche, santé, environnement et travail [Rennes] (Irset) ; Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor>
<contributor>Department of Genetics [Boston] ; Harvard Medical School [Boston] (HMS)</contributor>
<contributor>Rennes Metropole</contributor>
<contributor> National Institutes of Health [GM100233, 4R00GM111744]</contributor>
<contributor> National Science Foundation [HO BCS-1032255]</contributor>
<contributor> Institut national de la sante et de la recherche medicale (Inserm)</contributor>
<contributor> Universite de Rennes 1</contributor>
<contributor> Ecole des hautes etudes en sante publique (EHESP-School of Public Health)</contributor>
<contributor> Universite Sorbonne Paris Cite (USPC)</contributor>
<description>International audience</description>
<source>ISSN: 0737-4038</source>
<source>EISSN: 1537-1719</source>
<source>Molecular Biology and Evolution</source>
<publisher>Oxford University Press (OUP)</publisher>
<identifier>hal-01578587</identifier>
<identifier>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01578587</identifier>
<identifier>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01578587/document</identifier>
<identifier>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01578587/file/J%C3%A9gou%20et%20al%20-%20Meiotic%20Genes%20Are%20Enriched.pdf</identifier>
<source>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01578587</source>
<source>Molecular Biology and Evolution, Oxford University Press (OUP), 2017, 34 (8), pp.1974-1980. 〈10.1093/molbev/msx141〉</source>
<identifier>DOI : 10.1093/molbev/msx141</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1093/molbev/msx141</relation>
<identifier>PUBMED : 28444387</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/28444387</relation>
<language>en</language>
<subject lang=en> germ cells</subject>
<subject lang=en>archaic hominin admixture</subject>
<subject lang=en> testis</subject>
<subject lang=en> genetic incompatibilities</subject>
<subject lang=en> meiosis</subject>
<subject>[SDV.GEN.GH] Life Sciences [q-bio]/Genetics/Human genetics</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>About 1-6% of the genetic ancestry of modern humans today originates from admixture with archaic humans. It has recently been shown that autosomal genomic regions with a reduced proportion of Neanderthal and Denisovan ancestries (NA and DA) are significantly enriched in genes that are more expressed in testis than in other tissues. To determine whether a cellular segregation pattern would exist, we combined maps of archaic introgression with a cross-analysis of three transcriptomic datasets deciphering the transcriptional landscape of human gonadal cell types. We reveal that the regions deficient in both NA and DA contain a significant enrichment of genes transcribed in meiotic germ cells. The interbreeding of anatomically modern humans with archaic humans may have introduced archaic-derived alleles that contributed to genetic incompatibilities affecting meiosis that were subsequently purged by natural selection.</description>
<date>2017</date>
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