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<title lang=en>Mapping of Brain lipid binding protein (Blbp) in the brain of adult zebrafish, co-expression with aromatase B and links with proliferation</title>
<creator>Diotel, Nicolas</creator>
<creator>Vaillant, Colette</creator>
<creator>Kah, Olivier</creator>
<creator>Pellegrini, Elisabeth</creator>
<contributor>Diabète athérothrombose et thérapies Réunion Océan Indien (DéTROI) ; Université de la Réunion (UR) - Institut National de la Santé et de la Recherche Médicale (INSERM)</contributor>
<contributor>Institut de recherche, santé, environnement et travail [Rennes] (Irset) ; Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor>
<description>International audience</description>
<source>ISSN: 1567-133X</source>
<source>Gene Expression Patterns</source>
<publisher>Elsevier</publisher>
<identifier>hal-01237088</identifier>
<identifier>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01237088</identifier>
<source>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01237088</source>
<source>Gene Expression Patterns, Elsevier, 2016, 20 (1), pp. 42-54. 〈10.1016/j.gep.2015.11.003〉</source>
<identifier>DOI : 10.1016/j.gep.2015.11.003</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1016/j.gep.2015.11.003</relation>
<identifier>PUBMED : 26611722</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/26611722</relation>
<language>en</language>
<subject lang=en>Estrogen</subject>
<subject lang=en>Neurogenesis</subject>
<subject lang=en>Radial glial cells</subject>
<subject lang=en>Zebrafish</subject>
<subject lang=en>Aromatase B</subject>
<subject lang=en>Blbp</subject>
<subject>[SDV] Life Sciences [q-bio]</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>Adult fish exhibit a strong neurogenic capacity due to the persistence of radial glial progenitor cells. In zebrafish, radial glial cells display well-established markers such as the estrogen-synthesizing enzyme (AroB) and the brain lipid binding protein (Blbp), which is known to strongly bind omega-3 polyunsaturated fatty acids such as docosahexaenoic acid (DHA). While Blpb is mainly described in the telencephalon of adult zebrafish, its expression in the remaining regions of the brain is poorly documented. The present study was designed to further investigate Blbp expression in the brain, its co-expression with AroB, and its link with radial glial cells proliferation in zebrafish. We generated a complete and detailed mapping of Blbp expression in the whole brain and show its complete co-expression with AroB, except in some tectal and hypothalamic regions. By performing PCNA and Blbp immunohistochemistry on cyp19a1b-GFP (AroB-GFP) fish, we also demonstrated preferential Blbp expression in proliferative radial glial cells in almost all regions studied. To our knowledge, this is the first complete and detailed mapping of Blbp-expressing cells showing strong association between Blbp and radial glial cell proliferation in the adult brain of fish. Given that zebrafish is now recognized models for studying neurogenesis and brain repair, our data provide detailed characterization of Blbp in the entire brain and open up a broad field of research investigating the role of omega-3 polyunsaturated fatty acids in neural stem cell activity in fish</description>
<date>2016</date>
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