untitled
<OAI-PMH schemaLocation=http://www.openarchives.org/OAI/2.0/ http://www.openarchives.org/OAI/2.0/OAI-PMH.xsd>
<responseDate>2018-01-15T18:30:25Z</responseDate>
<request identifier=oai:HAL:hal-01134189v1 verb=GetRecord metadataPrefix=oai_dc>http://api.archives-ouvertes.fr/oai/hal/</request>
<GetRecord>
<record>
<header>
<identifier>oai:HAL:hal-01134189v1</identifier>
<datestamp>2018-01-11</datestamp>
<setSpec>type:ART</setSpec>
<setSpec>subject:sdv</setSpec>
<setSpec>collection:UNIV-RENNES1</setSpec>
<setSpec>collection:CNRS</setSpec>
<setSpec>collection:UNIV-AG</setSpec>
<setSpec>collection:UNIV-FCOMTE</setSpec>
<setSpec>collection:IRSET</setSpec>
<setSpec>collection:HL</setSpec>
<setSpec>collection:UNIV-PARIS5</setSpec>
<setSpec>collection:IFR140</setSpec>
<setSpec>collection:UNIV-GRENOBLE1</setSpec>
<setSpec>collection:IRSET-HIAEC</setSpec>
<setSpec>collection:BIOSIT</setSpec>
<setSpec>collection:UGA</setSpec>
<setSpec>collection:UR1-UFR-SVE</setSpec>
<setSpec>collection:STATS-UR1</setSpec>
<setSpec>collection:UR1-HAL</setSpec>
<setSpec>collection:EHESP</setSpec>
<setSpec>collection:USPC</setSpec>
<setSpec>collection:UR1-SDV</setSpec>
<setSpec>collection:IRSET-2</setSpec>
<setSpec>collection:UNIV-ANGERS</setSpec>
<setSpec>collection:CHRONO-ENVIRONNEMENT</setSpec>
<setSpec>collection:UNIV-CAEN</setSpec>
<setSpec>collection:COMUE-NORMANDIE</setSpec>
<setSpec>collection:UNIV-MONTPELLIER</setSpec>
</header>
<metadata><dc>
<publisher>HAL CCSD</publisher>
<title lang=en>Molecular diagnosis of toxoplasmosis in immunocompromised patients: a three-year multicenter retrospective study.</title>
<creator>Robert-Gangneux, Florence</creator>
<creator>Sterkers, Yvon</creator>
<creator>Yera, Hélène</creator>
<creator>Accoceberry, Isabelle</creator>
<creator>Menotti, Jean</creator>
<creator>Cassaing, Sophie</creator>
<creator>Brenier-Pinchart, Marie-Pierre</creator>
<creator>Hennequin, Christophe</creator>
<creator>Delhaes, Laurence</creator>
<creator>Bonhomme, Julie</creator>
<creator>Villena, Isabelle</creator>
<creator>Scherer, Emeline</creator>
<creator>Dalle, Frédéric</creator>
<creator>Touafek, Feriel</creator>
<creator>Filisetti, Denis</creator>
<creator>Varlet-Marie, Emmanuelle</creator>
<creator>Pelloux, Hervé</creator>
<creator>Bastien, Patrick</creator>
<contributor>Service de Parasitologie-Mycologie [Rennes] ; Université de Rennes 1 (UR1) - Hôpital Pontchaillou - CHU Pontchaillou [Rennes]</contributor>
<contributor>Institut de recherche, santé, environnement et travail [Rennes] (Irset) ; Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor>
<contributor>Laboratoire de Parasitologie-Mycologie, Montpellier (MIVEGEC) ; Centre National de la Recherche Scientifique (CNRS) - Institut de recherche pour le développement [IRD] : UR224 - Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier) - Université Montpellier 2 - Sciences et Techniques (UM2) - Université Montpellier 1 (UM1) - Université de Montpellier (UM)</contributor>
<contributor>Institut Cochin (UM3 (UMR 8104 / U1016)) ; Institut National de la Santé et de la Recherche Médicale (INSERM) - Université Paris Descartes - Paris 5 (UPD5) - Centre National de la Recherche Scientifique (CNRS)</contributor>
<contributor>Microbiologie cellulaire et moléculaire et pathogénicité (MCMP) ; Université Bordeaux Segalen - Bordeaux 2 - Centre National de la Recherche Scientifique (CNRS)</contributor>
<contributor>Service de Parasitologie et Mycologie ; CHU Toulouse [Toulouse] - Hôpital Purpan - Institut Fédératif de Biologie (IFB)</contributor>
<contributor>Laboratoire Adaptation et pathogénie des micro-organismes [Grenoble] (LAPM) ; Université Joseph Fourier - Grenoble 1 (UJF) - Centre National de la Recherche Scientifique (CNRS)</contributor>
<contributor>CHU Saint-Antoine [APHP]</contributor>
<contributor>CHU Caen ; Université de Caen Normandie (UNICAEN) ; Normandie Université (NU) - Normandie Université (NU) - CHU Caen</contributor>
<contributor>Laboratoire Chrono-environnement (LCE) ; Université Bourgogne Franche-Comté (UBFC) - Université de Franche-Comté (UFC) - Centre National de la Recherche Scientifique (CNRS)</contributor>
<description>International audience</description>
<source>ISSN: 0095-1137</source>
<source>Journal of Clinical Microbiology</source>
<publisher>American Society for Microbiology</publisher>
<identifier>hal-01134189</identifier>
<identifier>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01134189</identifier>
<source>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01134189</source>
<source>Journal of Clinical Microbiology, American Society for Microbiology, 2015, 53 (5), pp. 1677-1684. 〈10.1128/JCM.03282-14 〉</source>
<identifier>DOI : 10.1128/JCM.03282-14 </identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1128/JCM.03282-14 </relation>
<identifier>PUBMED : 25762774</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/25762774</relation>
<language>en</language>
<subject>[SDV] Life Sciences [q-bio]</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>Toxoplasmosis is a life-threatening infection in immunocompromised patients (ICPs). The definite diagnosis relies on parasite DNA detection, but the incidence and burden of disease are ill-known in HIV-negative patients. A three-year retrospective study was conducted in 15 reference laboratories from the network of the French National Reference Center for Toxoplasmosis, to record the frequency of Toxoplasma DNA detection in ICPs, to review the molecular methods used for diagnosis and the prevention measures implemented in transplant patients. During the study period, out of 31,640 PCR performed in ICPs, 610 were positive (323 patients). Blood (n=337), cerebrospinal fluid (n=101) and aqueous humor (n=100) samples were more frequently positive. Chemoprophylaxis schemes in transplant patients differed between centers. PCR follow-up of allogeneic hematopoietic stem-cell transplant (allo-HSCT) patients was implemented in 8/15 centers. Data from 180 patients (13 centers) were further analyzed regarding clinical setting and outcome. Only 68/180 (38%) patients were HIV+; the remaining 62% consisted in 72 HSCT, 14 solid-organ transplants, and 26 miscellaneous immunodeficiencies. Cerebral toxoplasmosis and disseminated toxoplasmosis were most frequently observed in HIV and transplant patients, respectively. Of 72 allo-HSCT patients with a positive PCR, 23 were asymptomatic; all were diagnosed in centers performing systematic blood PCR follow-up, and received specific treatment. Overall survival of allo-HSCT patients at two months was better in centers with PCR follow-up than in other centers (p<0.01). This study provides updated data on the frequency of toxoplasmosis in HIV-negative ICPs and suggests that regular PCR follow-up of allo-HSCT patients could guide pre-emptive treatment and improve outcome.</description>
<date>2015-05</date>
</dc>
</metadata>
</record>
</GetRecord>
</OAI-PMH>
