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<title lang=en>Myofibrillar misalignment correlated to triad disappearance of mdx mouse gastrocnemius muscle probed by SHG microscopy</title>
<creator>Rouède, Denis</creator>
<creator>Coumailleau, Pascal</creator>
<creator>Schaub, Emmanuel</creator>
<creator>Bellanger, Jean-Jacques</creator>
<creator>Blanchard-Desce, Mireille</creator>
<creator>Tiaho, François</creator>
<contributor>Institut de Physique de Rennes (IPR) ; Université de Rennes 1 (UR1) - Centre National de la Recherche Scientifique (CNRS)</contributor>
<contributor>Institut de recherche, santé, environnement et travail [Rennes] (Irset) ; Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor>
<contributor>Laboratoire Traitement du Signal et de l'Image (LTSI) ; Université de Rennes 1 (UR1) - Institut National de la Santé et de la Recherche Médicale (INSERM)</contributor>
<contributor>Institut des Sciences Moléculaires (ISM) ; Université Montesquieu - Bordeaux 4 - Université Sciences et Technologies - Bordeaux 1 - École Nationale Supérieure de Chimie et de Physique de Bordeaux (ENSCPB) - Centre National de la Recherche Scientifique (CNRS)</contributor>
<contributor>This work was supported by Région Bretagne, Rennes Métropole, Conseil Général d'Ille-et- Villaine, CRITT Santé Bretagne, Ministère de l'Enseignement Supérieur et de la Recherche and the European Union Federal Funds FEDER. #</contributor>
<description>International audience</description>
<source>ISSN: 2156-7085</source>
<source>EISSN: 2156-7085</source>
<source>Biomedical optics express</source>
<publisher>Optical Society</publisher>
<publisher>Optical Society - SOA Publishing</publisher>
<identifier>hal-00952823</identifier>
<identifier>https://hal.archives-ouvertes.fr/hal-00952823</identifier>
<identifier>https://hal.archives-ouvertes.fr/hal-00952823/document</identifier>
<identifier>https://hal.archives-ouvertes.fr/hal-00952823/file/boe-5-3-858_002.pdf</identifier>
<source>https://hal.archives-ouvertes.fr/hal-00952823</source>
<source>Biomedical optics express, Optical Society - SOA Publishing, 2014, 5 (3), pp.858-875. 〈10.1364/BOE.5.000858〉</source>
<identifier>DOI : 10.1364/BOE.5.000858</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1364/BOE.5.000858</relation>
<identifier>PUBMED : 24688819</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/24688819</relation>
<language>en</language>
<subject>170.3880;190.4160;180.4315</subject>
<subject>[SDV.IB] Life Sciences [q-bio]/Bioengineering</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>We show that the canonical single frequency sarcomeric SHG intensity pattern (SHG-IP) of control muscles is converted to double frequency sarcomeric SHG-IP in preserved mdx mouse gastrocnemius muscles in the vicinity of necrotic fibers. These double frequency sarcomeric SHG-IPs are often spatially correlated to double frequency sarcomeric two-photon excitation fluorescence (TPEF) emitted from Z-line and I-bands and to one centered spot SHG angular intensity pattern (SHG-AIP) suggesting that these patterns are signature of myofibrillar misalignement. This latter is confirmed with transmission electron microscopy (TEM). Moreover, a good spatial correlation between SHG signature of myofibrillar misalignment and triad reduction is established. Theoretical simulation of sarcomeric SHG-IP is used to demonstrate the correlation between change of SHG-IP and -AIP and myofibrillar misalignment. The extreme sensitivity of SHG microscopy to reveal the submicrometric organization of A-band thick filaments is highlighted. This report is a first step toward future studies aimed at establishing live SHG signature of myofibrillar misalignment involving excitation contraction defects due to muscle damage and disease.</description>
<date>2014</date>
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