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<title lang=en>The MAPK MEK1/2-ERK1/2 Pathway and Its Implication in Hepatocyte Cell Cycle Control.</title>
<creator>Guégan, Jean-Philippe</creator>
<creator>Frémin, Christophe</creator>
<creator>Baffet, Georges</creator>
<contributor>Institut de recherche, santé, environnement et travail [Rennes] (Irset) ; Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor>
<contributor>Institut National de la Santé et de la Recherche Médicale (Inserm); the Université de Rennes 1; Rennes Métropole; the Ligue contre le cancer (Ligue Grand-Ouest)</contributor>
<description>International audience</description>
<source>International Journal of Hepatology</source>
<identifier>hal-00875664</identifier>
<identifier>https://hal.archives-ouvertes.fr/hal-00875664</identifier>
<identifier>https://hal.archives-ouvertes.fr/hal-00875664/document</identifier>
<identifier>https://hal.archives-ouvertes.fr/hal-00875664/file/TheMAPKMEK12-accepted.pdf</identifier>
<source>https://hal.archives-ouvertes.fr/hal-00875664</source>
<source>International Journal of Hepatology, 2012, 2012, pp.328372. 〈10.1155/2012/328372〉</source>
<identifier>DOI : 10.1155/2012/328372</identifier>
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<identifier>PUBMED : 23133759</identifier>
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<language>en</language>
<subject>[SDV.MHEP.HEG] Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology</subject>
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<type>Journal articles</type>
<description lang=en>Primary cultures of hepatocytes are powerful models in studying the sequence of events that are necessary for cell progression from a G0-like state to S phase. The models mimic the physiological process of hepatic regeneration after liver injury or partial hepatectomy. Many reports suggest that the mitogen-activated protein kinase (MAPK) ERK1/2 can support hepatocyte proliferation in vitro and in vivo and the MEK/ERK cascade acts as an essential element in hepatocyte responses induced by the EGF. Moreover, its disregulation has been associated with the promotion of tumor cell growth of a variety of tumors, including hepatocellular carcinoma. Whereas the strict specificity of action of ERK1 and ERK2 is still debated, the MAPKs may have specific biological functions under certain contexts and according to the differentiation status of the cells, notably hepatocytes. In this paper, we will focus on MEK1/2-ERK1/2 activations and roles in normal rodent hepatocytes in vitro and in vivo after partial hepatectomy and in human hepatocarcinoma cells. The possible specificity of ERK1 and ERK2 in normal and transformed hepatocyte will be discussed in regard to other differentiated and undifferentiated cellular models.</description>
<date>2012</date>
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