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<title lang=en>A novel action of follicle-stimulating hormone in the ovary promotes estradiol production without inducing excessive follicular growth before puberty</title>
<creator>François, Charlotte M.</creator>
<creator>Petit, Florence</creator>
<creator>Giton, Frank</creator>
<creator>Gougeon, Alain</creator>
<creator>Ravel, Célia</creator>
<creator>Magre, Solange</creator>
<creator>Cohen-Tannoudji, Joëlle</creator>
<creator>Guigon, Celine J.</creator>
<contributor>Physiologie de l'Axe Gonadotrope (PAG U1133) ; Biologie Fonctionnelle et Adaptative (BFA) ; Université Paris Diderot - Paris 7 (UPD7) - Centre National de la Recherche Scientifique (CNRS) - Université Paris Diderot - Paris 7 (UPD7) - Centre National de la Recherche Scientifique (CNRS)</contributor>
<contributor>Institut Mondor de Recherche Biomédicale (IMRB) ; Institut National de la Santé et de la Recherche Médicale (INSERM) - IFR10 - Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)</contributor>
<contributor>Equipe 4 ; Tumeurs endocrines digestives : mécanismes de la tumorigenèse et de la progression tumorale ; Université Claude Bernard Lyon 1 (UCBL) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Université Claude Bernard Lyon 1 (UCBL) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Centre de Recherche en Cancérologie de Lyon (CRCL) ; Centre Léon Bérard [Lyon] - Université Claude Bernard Lyon 1 (UCBL) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Centre National de la Recherche Scientifique (CNRS) - Centre Léon Bérard [Lyon] - Institut National de la Santé et de la Recherche Médicale (INSERM) - Centre National de la Recherche Scientifique (CNRS)</contributor>
<contributor>Institut de recherche, santé, environnement et travail [Rennes] (Irset) ; Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor>
<contributor>Biologie Fonctionnelle et Adaptative (BFA) ; Université Paris Diderot - Paris 7 (UPD7) - Centre National de la Recherche Scientifique (CNRS)</contributor>
<contributor>Physiologie et physiopathologie (PP) ; Université Pierre et Marie Curie - Paris 6 (UPMC) - Centre National de la Recherche Scientifique (CNRS)</contributor>
<description>International audience</description>
<source>ISSN: 2045-2322</source>
<source>EISSN: 2045-2322</source>
<source>Scientific Reports</source>
<publisher>Nature Publishing Group</publisher>
<identifier>hal-01516023</identifier>
<identifier>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01516023</identifier>
<source>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01516023</source>
<source>Scientific Reports, Nature Publishing Group, 2017, 7, pp.46222. 〈10.1038/srep46222〉</source>
<identifier>DOI : 10.1038/srep46222</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1038/srep46222</relation>
<identifier>PUBMED : 28397811</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/28397811</relation>
<identifier>PUBMEDCENTRAL : PMC5387682</identifier>
<language>en</language>
<subject>[SDV.EE.SANT] Life Sciences [q-bio]/Ecology, environment/Health</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>In cyclic females, FSH stimulates ovarian estradiol (E2) production and follicular growth up to the terminal stage. A transient elevation in circulating FSH and E2 levels occurs shortly after birth. But what could be the action of FSH on the ovary during this period, and in particular how it stimulates ovarian steroidogenesis without supporting terminal follicular maturation is intriguing. By experimentally manipulating FSH levels, we demonstrate in mice that the mid-infantile elevation in FSH is mandatory for E2 production by the immature ovary, but that it does not stimulate follicle growth. Importantly, FSH increases aromatase expression to stimulate E2 synthesis, however it becomes unable to induce cyclin D2, a major driver of granulosa cell proliferation. Besides, although FSH prematurely induces luteinizing hormone (LH) receptor expression in granulosa cells, LH pathway is not functional in these cells to induce their terminal differentiation. In line with these results, supplying infantile mice with a superovulation regimen exacerbates E2 production, but it does not stimulate the growth of follicles and it does not induce ovulation. Overall, our findings unveil a regulation whereby high postnatal FSH concentrations ensure the supply of E2 required for programming adult reproductive function without inducing follicular maturation before puberty.</description>
<date>2017</date>
</dc>
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