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<title lang=en>A new prognostic clinicopathological classification of pituitary adenomas: a multicentric case-control study of 410 patients with 8 years post-operative follow-up.</title>
<creator>Trouillas, Jacqueline</creator>
<creator>Roy, Pascal</creator>
<creator>Sturm, Nathalie</creator>
<creator>Dantony, Emmanuelle</creator>
<creator>Cortet-Rudelli, Christine</creator>
<creator>Viennet, Gabriel</creator>
<creator>Bonneville, Jean-François</creator>
<creator>Assaker, Richard</creator>
<creator>Auger, Carole</creator>
<creator>Brue, Thierry</creator>
<creator>Cornelius, Aurélie</creator>
<creator>Dufour, Henry</creator>
<creator>Jouanneau, Emmanuel</creator>
<creator>François, Patrick</creator>
<creator>Galland, Françoise</creator>
<creator>Mougel, François</creator>
<creator>Chapuis, François</creator>
<creator>Villeneuve, Laurent</creator>
<creator>Maurage, Claude-Alain</creator>
<creator>Figarella-Branger, Dominique</creator>
<creator>Raverot, Gérald</creator>
<creator>Barlier, Anne, </creator>
<creator>Bernier, M.</creator>
<creator>Bonnet, Fabrice</creator>
<creator>Borson-Chazot, F.</creator>
<creator>Brassier, Gilles</creator>
<creator>Caulet-Maugendre, S.</creator>
<creator>Chabre, O.</creator>
<creator>Chanson, P.</creator>
<creator>Cottier, J. F.</creator>
<creator>Delemer, B.</creator>
<creator>Delgrange, E.</creator>
<creator>Di Tommaso, L.</creator>
<creator>Eimer, S.</creator>
<creator>Gaillard, S.</creator>
<creator>Jan, M.</creator>
<creator>Girard, J. J.</creator>
<creator>Lapras, V.</creator>
<creator>Loiseau, H.</creator>
<creator>Passagia, J. G.</creator>
<creator>Patey, M.</creator>
<creator>Penfornis, A.</creator>
<creator>Poirier, J. Y.</creator>
<creator>Perrin, G.</creator>
<creator>Tabarin, A.</creator>
<contributor>Centre de recherche en neurosciences de Lyon ; Université Claude Bernard Lyon 1 (UCBL) - Université Jean Monnet [Saint-Étienne] (UJM) - Université de Lyon - Institut National de la Santé et de la Recherche Médicale (INSERM) - Centre National de la Recherche Scientifique (CNRS)</contributor>
<contributor>Laboratoire Biostatistique-Santé (LBS) ; Université Claude Bernard Lyon 1 (UCBL) - Hospices Civils de Lyon - Centre National de la Recherche Scientifique (CNRS)</contributor>
<contributor>Estrogènes, Expression génique et pathologies du Système Nerveux Central - UFC (E2SNC / ESTROGENES) ; Université de Franche-Comté (UFC)</contributor>
<contributor>IFR des neurosciences de Lyon (IFNL) ; Université Claude Bernard Lyon 1 (UCBL) - Hospices Civils de Lyon - Hôpital du Vinatier - Institut National de la Santé et de la Recherche Médicale (INSERM) - Centre National de la Recherche Scientifique (CNRS)</contributor>
<contributor>Centre de recherche en neurobiologie - neurophysiologie de Marseille (CRN2M) ; Aix Marseille Université (AMU) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Centre National de la Recherche Scientifique (CNRS)</contributor>
<contributor>Service d'endocrinologie diabétologie et nutrition [Rennes] ; Université de Rennes 1 (UR1) - CHU Pontchaillou [Rennes] - Hôpital Anne-de-Bretagne</contributor>
<contributor>Service de diabétologie - endocrinologie ; Centre Hospitalier Régional Universitaire [Besançon] (CHRU Besançon) - Hôpital Jean Minjoz</contributor>
<contributor>Unité de Méthodologie en Recherche Clinique ; Université Claude Bernard Lyon 1 (UCBL) - Hospices Civils de Lyon</contributor>
<contributor>Centre de recherche Jean-Pierre Aubert-Neurosciences et Cancer ; Institut National de la Santé et de la Recherche Médicale (INSERM) - Université de Lille, Droit et Santé</contributor>
<contributor>Centre de Recherches en Oncologie biologique et Oncopharmacologie (CRO2) ; Aix Marseille Université (AMU) - Hôpital de la Timone [CHU - APHM] (TIMONE) - Institut National de la Santé et de la Recherche Médicale (INSERM)</contributor>
<contributor>Centre Hospitalier Universitaire (Rennes)</contributor>
<contributor>Foie, métabolismes et cancer ; Université de Rennes 1 (UR1) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor>
<contributor>Service de neurochirurgie [Rennes] ; Université de Rennes 1 (UR1) - Hôpital Pontchaillou - CHU Pontchaillou [Rennes]</contributor>
<contributor>Institut de recherche, santé, environnement et travail [Rennes] (Irset) ; Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor>
<description>International audience</description>
<source>ISSN: 0001-6322</source>
<source>EISSN: 1432-0533</source>
<source>Acta Neuropathologica</source>
<publisher>Springer Verlag</publisher>
<identifier>hal-00875723</identifier>
<identifier>https://hal.archives-ouvertes.fr/hal-00875723</identifier>
<source>https://hal.archives-ouvertes.fr/hal-00875723</source>
<source>Acta Neuropathologica, Springer Verlag, 2013, 126 (1), pp.123-35. 〈10.1007/s00401-013-1084-y〉</source>
<identifier>DOI : 10.1007/s00401-013-1084-y</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1007/s00401-013-1084-y</relation>
<identifier>PUBMED : 23400299</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/23400299</relation>
<language>en</language>
<subject lang=en>Classification</subject>
<subject lang=en>Pituitary tumour</subject>
<subject lang=en>Pituitary adenoma</subject>
<subject>[SDV.MHEP.HEG] Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>Pituitary adenomas are currently classified by histological, immunocytochemical and numerous ultrastructural characteristics lacking unequivocal prognostic correlations. We investigated the prognostic value of a new clinicopathological classification with grades based on invasion and proliferation. This retrospective multicentric case-control study comprised 410 patients who had surgery for a pituitary tumour with long-term follow-up. Using pituitary magnetic resonance imaging for diagnosis of cavernous or sphenoid sinus invasion, immunocytochemistry, markers of the cell cycle (Ki-67, mitoses) and p53, tumours were classified according to size (micro, macro and giant), type (PRL, GH, FSH/LH, ACTH and TSH) and grade (grade 1a: non-invasive, 1b: non-invasive and proliferative, 2a: invasive, 2b: invasive and proliferative, and 3: metastatic). The association between patient status at 8-year follow-up and age, sex, and classification was evaluated by two multivariate analyses assessing disease- or recurrence/progression-free status. At 8 years after surgery, 195 patients were disease-free (controls) and 215 patients were not (cases). In 125 of the cases the tumours had recurred or progressed. Analyses of disease-free and recurrence/progression-free status revealed the significant prognostic value (p < 0.001; p < 0.05) of age, tumour type, and grade across all tumour types and for each tumour type. Invasive and proliferative tumours (grade 2b) had a poor prognosis with an increased probability of tumour persistence or progression of 25- or 12-fold, respectively, as compared to non-invasive tumours (grade 1a). This new, easy to use clinicopathological classification of pituitary endocrine tumours has demonstrated its prognostic worth by strongly predicting the probability of post-operative complete remission or tumour progression and so could help clinicians choose the best post-operative therapy.</description>
<date>2013-07</date>
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