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<datestamp>2017-12-21</datestamp>
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<title lang=en>Novel role for anti-Müllerian hormone in the regulation of GnRH neuron excitability and hormone secretion</title>
<creator>Cimino, Irène</creator>
<creator>Casoni, Filippo</creator>
<creator>Liu, Xinhuai</creator>
<creator>Messina, Andrea</creator>
<creator>Parkash, Jyoti</creator>
<creator>Jamin, Soazik P.</creator>
<creator>Catteau-Jonard, Sophie</creator>
<creator>Collier, Francis</creator>
<creator>Baroncini, Marc</creator>
<creator>Dewailly, Didier</creator>
<creator>Pigny, Pascal</creator>
<creator>Prescott, Mel</creator>
<creator>Campbell, Rebecca</creator>
<creator>Herbison, Allan E.</creator>
<creator>Prévot, Vincent</creator>
<creator>Giacobini, Paolo</creator>
<contributor>Centre de recherche Jean-Pierre Aubert-Neurosciences et Cancer ; Institut National de la Santé et de la Recherche Médicale (INSERM) - Université de Lille, Droit et Santé</contributor>
<contributor>Hôpital Saint-Joseph [Marseille]</contributor>
<contributor>Institut de recherche, santé, environnement et travail [Rennes] (Irset) ; Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor>
<contributor>Departments of Endocrine Gynaecology and Reproductive Medicine, Hôpital Jeanne de Flandre, Centre Hospitalier Régional Universitaire, Faculty of Medicine, Université de Lille II ; Université de Lille, Droit et Santé</contributor>
<contributor>Service de gynécologie ; Hôpital Jeanne de Flandre [Lille] - Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)</contributor>
<contributor> Centre de Recherche Jean-Pierre Aubert, UMR 837, Développement and Plasticity of the Postnatal Brain ; Université Lille Nord de France - Institut National de la Santé et de la Recherche Médicale</contributor>
<contributor>Clinique de Neurochirurgie ; Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)</contributor>
<contributor>Service de neurochirurgie ; Hôpital Roger Salengro - Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)</contributor>
<contributor>Centre de Biologie et Pathologie ; Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)</contributor>
<contributor>U837, Développement et Plasticité du cerveau post-natal, Centre de Recherche Jean-Pierre Aubert ; Institut National de la Santé et de la Recherche Médicale</contributor>
<description>International audience</description>
<source>ISSN: 2041-1723</source>
<source>EISSN: 2041-1723</source>
<source>Nature Communications</source>
<publisher>Nature Publishing Group</publisher>
<identifier>hal-01259206</identifier>
<identifier>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01259206</identifier>
<source>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01259206</source>
<source>Nature Communications, Nature Publishing Group, 2016, 7, pp.10055. 〈10.1038/ncomms10055〉</source>
<identifier>DOI : 10.1038/ncomms10055</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1038/ncomms10055</relation>
<identifier>PUBMED : 26753790</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/26753790</relation>
<language>en</language>
<subject>[SDV] Life Sciences [q-bio]</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>Anti-Müllerian hormone (AMH) plays crucial roles in sexual differentiation and gonadal functions. However, the possible extragonadal effects of AMH on the hypothalamic-pituitary-gonadal axis remain unexplored. Here we demonstrate that a significant subset of GnRH neurons both in mice and humans express the AMH receptor, and that AMH potently activates the GnRH neuron firing in mice. Combining in vivo and in vitro experiments, we show that AMH increases GnRH-dependent LH pulsatility and secretion, supporting a central action of AMH on GnRH neurons. Increased LH pulsatility is an important pathophysiological feature in many cases of polycystic ovary syndrome (PCOS), the most common cause of female infertility, in which circulating AMH levels are also often elevated. However, the origin of this dysregulation remains unknown. Our findings raise the intriguing hypothesis that AMH-dependent regulation of GnRH release could be involved in the pathophysiology of fertility and could hold therapeutic potential for treating PCOS</description>
<date>2016</date>
</dc>
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