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<title lang=en>The neurogenic factor NeuroD1 is expressed in post-mitotic cells during juvenile and adult Xenopus neurogenesis and not in progenitor or radial glial cells.</title>
<creator>D'Amico, Laure Anne</creator>
<creator>Boujard, Daniel</creator>
<creator>Coumailleau, Pascal</creator>
<contributor>Scaning ; Interactions cellulaires et moléculaires (ICM) ; Université de Rennes 1 (UR1) - IFR140 - Centre National de la Recherche Scientifique (CNRS) - Université de Rennes 1 (UR1) - IFR140 - Centre National de la Recherche Scientifique (CNRS)</contributor>
<contributor>Institut de recherche, santé, environnement et travail [Rennes] (Irset) ; Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor>
<contributor>Région Bretagne ; Ministère de l'Education nationale</contributor>
<description>International audience</description>
<source>ISSN: 1932-6203</source>
<source>PLoS ONE</source>
<publisher>Public Library of Science</publisher>
<identifier>hal-00877023</identifier>
<identifier>https://hal-univ-rennes1.archives-ouvertes.fr/hal-00877023</identifier>
<identifier>https://hal-univ-rennes1.archives-ouvertes.fr/hal-00877023/document</identifier>
<identifier>https://hal-univ-rennes1.archives-ouvertes.fr/hal-00877023/file/The_Neurogenic_Factor-accepted.pdf</identifier>
<source>https://hal-univ-rennes1.archives-ouvertes.fr/hal-00877023</source>
<source>PLoS ONE, Public Library of Science, 2013, 8 (6), pp.e66487. 〈10.1371/journal.pone.0066487〉</source>
<identifier>DOI : 10.1371/journal.pone.0066487</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0066487</relation>
<identifier>PUBMED : 23799108</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/23799108</relation>
<language>en</language>
<subject>[SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>In contrast to mammals that have limited proliferation and neurogenesis capacities, the Xenopus frog exhibit a great potential regarding proliferation and production of new cells in the adult brain. This ability makes Xenopus a useful model for understanding the molecular programs required for adult neurogenesis. Transcriptional factors that control adult neurogenesis in vertebrate species undergoing widespread neurogenesis are unknown. NeuroD1 is a member of the family of proneural genes, which function during embryonic neurogenesis as a potent neuronal differentiation factor. Here, we study in detail the expression of NeuroD1 gene in the juvenile and adult Xenopus brains by in situ hybridization combined with immunodetections for proliferation markers (PCNA, BrdU) or in situ hybridizations for cell type markers (Vimentin, Sox2). We found NeuroD1 gene activity in many brain regions, including olfactory bulbs, pallial regions of cerebral hemispheres, preoptic area, habenula, hypothalamus, cerebellum and medulla oblongata. We also demonstrated by double staining NeuroD1/BrdU experiments, after long post-BrdU administration survival times, that NeuroD1 gene activity was turned on in new born neurons during post-metamorphic neurogenesis. Importantly, we provided evidence that NeuroD1-expressing cells at this brain developmental stage were post-mitotic (PCNA-) cells and not radial glial (Vimentin+) or progenitors (Sox2+) cells.</description>
<date>2013</date>
</dc>
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