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<publisher>HAL CCSD</publisher>
<title lang=en>Normal muscle oxygen consumption and fatigability in sickle cell patients despite reduced microvascular oxygenation and hemorheological abnormalities.</title>
<creator>Waltz, Xavier</creator>
<creator>Pichon, Aurélien</creator>
<creator>Lemonne, Nathalie</creator>
<creator>Mougenel, Danièle</creator>
<creator>Lalanne-Mistrih, Marie-Laure</creator>
<creator>Lamarre, Yann</creator>
<creator>Tarer, Vanessa</creator>
<creator>Tressières, Benoit</creator>
<creator>Etienne-Julan, Maryse</creator>
<creator>Hardy-Dessources, Marie-Dominique</creator>
<creator>Hue, Olivier</creator>
<creator>Connes, Philippe</creator>
<contributor>Protéines de la membrane érythrocytaire et homologues non-érythroides ; Université des Antilles et de la Guyane (UAG) - Institut National de la Transfusion Sanguine [Paris] (INTS) - Université Paris Diderot - Paris 7 (UPD7) - Université de la Réunion (UR) - Institut National de la Santé et de la Recherche Médicale (INSERM)</contributor>
<contributor>Adaptations au Climat Tropical, Exercice et Santé (ACTES) ; Université des Antilles et de la Guyane (UAG)</contributor>
<contributor>Réponses Cellulaires et Fonctionnelles à l'Hypoxie (LRPH) ; Université Paris 13 (UP13) - Université Sorbonne Paris Cité (USPC) - UFR SMBH</contributor>
<contributor>Unité Transversale de la Drépanocytose ; Hôpital Ricou - CHU de Pointe-à-Pitre/Abymes</contributor>
<contributor>Centre d'investigation clinique Antilles-Guyane ; Institut National de la Santé et de la Recherche Médicale (INSERM) - CH Cayenne</contributor>
<contributor>Service d'Orthopédie et de Traumatologie ; Université des Antilles et de la Guyane (UAG) - CHU Pointe-à-Pitre/Abymes</contributor>
<description>International audience</description>
<source>ISSN: 1932-6203</source>
<source>PLoS ONE</source>
<publisher>Public Library of Science</publisher>
<identifier>inserm-00849035</identifier>
<identifier>http://www.hal.inserm.fr/inserm-00849035</identifier>
<identifier>http://www.hal.inserm.fr/inserm-00849035/document</identifier>
<identifier>http://www.hal.inserm.fr/inserm-00849035/file/2013_Waltz_-_Normal_muscle_oxygen_consumption_and_fatigability_in_sickle_cell_patients.pdf</identifier>
<source>http://www.hal.inserm.fr/inserm-00849035</source>
<source>PLoS ONE, Public Library of Science, 2012, 7 (12), pp.e52471. 〈10.1371/journal.pone.0052471〉</source>
<identifier>DOI : 10.1371/journal.pone.0052471</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0052471</relation>
<identifier>PUBMED : 23285055</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/23285055</relation>
<language>en</language>
<subject lang=en>muscle oxygenation</subject>
<subject lang=en>blood rheology</subject>
<subject lang=en>muscle strength</subject>
<subject lang=en>sickle cell syndromes</subject>
<subject>[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>BACKGROUND/AIM: Although it has been hypothesized that muscle metabolism and fatigability could be impaired in sickle cell patients, no study has addressed this issue. METHODS: We compared muscle metabolism and function (muscle microvascular oxygenation, microvascular blood flow, muscle oxygen consumption and muscle microvascular oxygenation variability, which reflects vasomotion activity, maximal muscle force and local muscle fatigability) and the hemorheological profile at rest between 16 healthy subjects (AA), 20 sickle cell-hemoglobin C disease (SC) patients and 16 sickle cell anemia (SS) patients. RESULTS: Muscle microvascular oxygenation was reduced in SS patients compared to the SC and AA groups and this reduction was not related to hemorhelogical abnormalities. No difference was observed between the three groups for oxygen consumption and vasomotion activity. Muscle microvascular blood flow was higher in SS patients compared to the AA group, and tended to be higher compared to the SC group. Multivariate analysis revealed that muscle oxygen consumption was independently associated with muscle microvascular blood flow in the two sickle cell groups (SC and SS). Finally, despite reduced muscle force in sickle cell patients, their local muscle fatigability was similar to that of the healthy subjects. CONCLUSIONS: Sickle cell patients have normal resting muscle oxygen consumption and fatigability despite hemorheological alterations and, for SS patients only, reduced muscle microvascular oxygenation and increased microvascular blood flow. Two alternative mechanisms can be proposed for SS patients: 1) the increased muscle microvascular blood flow is a way to compensate for the lower muscle microvascular oxygenation to maintain muscle oxygen consumption to normal values or 2) the reduced microvascular oxygenation coupled with a normal resting muscle oxygen consumption could indicate that there is slight hypoxia within the muscle which is not sufficient to limit mitochondrial respiration but increases muscle microvascular blood flow.</description>
<date>2012</date>
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