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<datestamp>2018-01-11</datestamp>
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<publisher>HAL CCSD</publisher>
<title lang=en>A Network of Paralogous Stress Response Transcription Factors in the Human Pathogen Candida glabrata</title>
<creator>Merhej, Jawad</creator>
<creator>Thiebaut, Antonin</creator>
<creator>Blugeon, Corinne</creator>
<creator>Pouch, Juliette</creator>
<creator>Chaouche, Mohammed El Amine Ali</creator>
<creator>Camadro, Jean-Michel</creator>
<creator>Le Crom, Stéphane</creator>
<creator>Lelandais, Gaëlle</creator>
<creator>Devaux, Frédéric</creator>
<contributor>Biologie Computationnelle et Quantitative = Laboratory of Computational and Quantitative Biology (LCQB) ; Université Pierre et Marie Curie - Paris 6 (UPMC) - Centre National de la Recherche Scientifique (CNRS)</contributor>
<contributor>Institut de biologie de l'école normale supérieure (IBENS) ; École normale supérieure - Paris (ENS Paris) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Centre National de la Recherche Scientifique (CNRS)</contributor>
<contributor>Institut Jacques Monod (IJM) ; Université Paris Diderot - Paris 7 (UPD7) - Centre National de la Recherche Scientifique (CNRS)</contributor>
<contributor>Evolution Paris Seine ; Université Nice Sophia Antipolis (UNS) ; Université Côte d'Azur (UCA) - Université Côte d'Azur (UCA) - Centre National de la Recherche Scientifique (CNRS) - Université des Antilles et de la Guyane (UAG) - Université Pierre et Marie Curie - Paris 6 (UPMC)</contributor>
<description>International audience</description>
<source>ISSN: 1664-302X</source>
<source>Frontiers in Microbiology</source>
<publisher>Frontiers Media</publisher>
<identifier>hal-01323791</identifier>
<identifier>http://hal.upmc.fr/hal-01323791</identifier>
<identifier>http://hal.upmc.fr/hal-01323791/document</identifier>
<identifier>http://hal.upmc.fr/hal-01323791/file/fmicb-07-00645.pdf</identifier>
<source>http://hal.upmc.fr/hal-01323791</source>
<source>Frontiers in Microbiology, Frontiers Media, 2016, 7, pp.645. 〈10.3389/fmicb.2016.00645〉</source>
<identifier>DOI : 10.3389/fmicb.2016.00645</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.3389/fmicb.2016.00645</relation>
<language>en</language>
<subject lang=en>evolution</subject>
<subject lang=en>yeast</subject>
<subject lang=en>Yap</subject>
<subject lang=en>ChIP-seq</subject>
<subject lang=en>transcriptome</subject>
<subject lang=en>regulatory networks</subject>
<subject>[SDV.MP.MYC] Life Sciences [q-bio]/Microbiology and Parasitology/Mycology</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>The yeast Candida glabrata has become the second cause of systemic candidemia in humans. However, relatively few genome-wide studies have been conducted in this organism and our knowledge of its transcriptional regulatory network is quite limited. In the present work, we combined genome-wide chromatin immunoprecipitation (ChIP-seq), transcriptome analyses, and DNA binding motif predictions to describe the regulatory interactions of the seven Yap (Yeast AP1) transcription factors of C. glabrata. We described a transcriptional network containing 255 regulatory interactions and 309 potential target genes. We predicted with high confidence the preferred DNA binding sites for 5 of the 7 CgYaps and showed a strong conservation of the Yap DNA binding properties between S. cerevisiae and C. glabrata. We provided reliable functional annotation for 3 of the 7 Yaps and identified for Yap1 and Yap5 a core regulon which is conserved in S. cerevisiae, C. glabrata, and C. albicans. We uncovered new roles for CgYap7 in the regulation of iron-sulfur cluster biogenesis, for CgYap1 in the regulation of heme biosynthesis and for CgYap5 in the repression of GRX4 in response to iron starvation. These transcription factors define an interconnected transcriptional network at the crossroads between redox homeostasis, oxygen consumption, and iron metabolism.</description>
<rights>http://creativecommons.org/licenses/by/</rights>
<date>2016</date>
</dc>
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