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<datestamp>2017-12-21</datestamp>
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<title lang=en>Organophosphate Insecticide Metabolites in Prenatal and Childhood Urine Samples and Intelligence Scores at 6 Years of Age: Results from the Mother-Child PELAGIE Cohort (France)</title>
<creator>Cartier, Chloé</creator>
<creator>Warembourg, Charline</creator>
<creator>Le Maner-Idrissi, Gaïd</creator>
<creator>Lacroix, Agnès</creator>
<creator>Rouget, Florence</creator>
<creator>Monfort, Christine</creator>
<creator>Limon, Gwendolina</creator>
<creator>Durand, Gaël</creator>
<creator>Saint-Amour, Dave</creator>
<creator>Cordier, Sylvaine</creator>
<creator>Chevrier, Cécile</creator>
<contributor>Université du Québec à Montréal (UQAM)</contributor>
<contributor>Institut de recherche, santé, environnement et travail [Rennes] (Irset) ; Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor>
<contributor> Laboratoire de Psychologie Expérimentale (LPE) ; Université de Bretagne Sud (UBS) - Université de Brest (UBO) - Université de Rennes 2 (UR2)</contributor>
<contributor>LABOCEA</contributor>
<contributor>Département de psychologie ; Université du Québec à Montréal (UQAM)</contributor>
<contributor>Centre de recherche et département d'ophtalmologie ; CHU Sainte Justine [Montréal]</contributor>
<description>International audience</description>
<source>Environmental Health Perspectives</source>
<identifier>hal-01207282</identifier>
<identifier>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01207282</identifier>
<source>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01207282</source>
<source>Environmental Health Perspectives, 2016, 124 (5), pp.674. 〈10.1289/ehp.1409472〉</source>
<identifier>DOI : 10.1289/ehp.1409472</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1289/ehp.1409472</relation>
<identifier>PUBMED : 26394442</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/26394442</relation>
<language>en</language>
<subject>[SDV] Life Sciences [q-bio]</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>BACKGROUND: Several studies suggest that exposure to organophosphate insecticides (OP) during pregnancy impairs neurodevelopment in children. OBJECTIVES: We evaluated associations between biomarkers of prenatal and postnatal OP exposure and cognitive function of 6-year-olds in a French longitudinal birth cohort. METHODS: In 2002-2006, the PELAGIE mother-child cohort enrolled pregnant women from Brittany. For a random subcohort, we measured nonspecific dialkylphosphate metabolites (DAP) of OP in one maternal urine sample, collected before 19 weeks' gestation, and in one urine sample collected from their 6-year-old children. Six subtests of the Wechsler Intelligence Scale for Children-4th edition (WISC-IV) was administered at 6 years to evaluate cognitive function (n=231). Linear regression models controlling for factors including maternal intelligence and the Home Observation for Measurement of the Environment score were used. RESULTS: WISC-IV scores were not significantly associated with prenatal or childhood total DAP metabolites. WISC verbal comprehension score was significantly higher in association with the highest maternal urinary concentrations of diethylphosphate metabolites (DE) (5.5; 95% CI: 0.8, 10.3 for extgreater 13.2 nmol/L versus extlessLOQ), while WISC working memory score was significantly lower in association with the highest urinary concentrations of DE metabolites at age 6 years (-3.6; 95% CI: -7.8, -0.6 for extgreater 11.1 nmol/L versus extlessLOD). CONCLUSION: This study found no evidence that prenatal OP exposure adversely affected cognitive function in 6-year-olds, perhaps because of the higher population's socioeconomic status than in previous studies though other causal and non-causal explanations are also possible. The negative association between WISC score and concurrent DE urinary concentrations requires replication by longitudinal studies investigating childhood OP exposure</description>
<date>2016</date>
</dc>
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