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<publisher>HAL CCSD</publisher>
<title lang=en>Occupational Exposure to Diesel Motor Exhaust and Lung Cancer: A Dose-Response Relationship Hidden by Asbestos Exposure Adjustment? The ICARE Study</title>
<creator>Matrat, Mireille</creator>
<creator>Guida, Florence</creator>
<creator>Céné, Sylvie</creator>
<creator>Fevotte, Joëlle</creator>
<creator>Carton, Matthieu</creator>
<creator>Cyr, Diane</creator>
<creator>Menvielle, Gwenn</creator>
<creator>Paget-Bailly, Sophie</creator>
<creator>Radoi, Loredana</creator>
<creator>Schmaus, Annie</creator>
<creator>Bara, Simona</creator>
<creator>Velten, Michel</creator>
<creator>Luce, Danièle</creator>
<creator>Stücker, Isabelle</creator>
<creator>Group, The Icare Study</creator>
<contributor>Unité de pathologie professionnelle ; CHI Créteil</contributor>
<contributor>Institut Mondor de Recherche Biomédicale (IMRB) ; Institut National de la Santé et de la Recherche Médicale (INSERM) - IFR10 - Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)</contributor>
<contributor>Centre de recherche en épidémiologie et santé des populations (CESP) ; Université de Versailles Saint-Quentin-en-Yvelines (UVSQ) - Université Paris-Sud - Paris 11 (UP11) - Assistance publique - Hôpitaux de Paris (AP-HP) - Hôpital Paul Brousse - Institut National de la Santé et de la Recherche Médicale (INSERM)</contributor>
<contributor>Unité Mixte de Recherche Epidémiologique et de Surveillance Transport Travail Environnement (UMRESTTE) ; Université Claude Bernard Lyon 1 (UCBL) - Institut National de Recherche sur les Transports et leur Sécurité (INRETS) - Institut de Veille Sanitaire (INVS)</contributor>
<contributor>Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)</contributor>
<contributor>Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP) ; Université Pierre et Marie Curie - Paris 6 (UPMC) - Institut National de la Santé et de la Recherche Médicale (INSERM)</contributor>
<contributor>Francim : Réseau français des registres des cancers ; CHU Toulouse [Toulouse] - Hôpital Purpan [Toulouse]</contributor>
<contributor>Registre des cancers de la Manche ; Centre Hospitalier Public du Cotentin</contributor>
<contributor>Service d'Epidémiologie et de Biostatistique ; Centre Paul Strauss : Centre Régional de Lutte contre le Cancer (CRLCC)</contributor>
<contributor>Institut de recherche, santé, environnement et travail [Rennes] (Irset) ; Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor>
<description>International audience</description>
<source>Journal of Cancer Epidemiology</source>
<identifier>hal-01205352</identifier>
<identifier>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01205352</identifier>
<source>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01205352</source>
<source>Journal of Cancer Epidemiology, 2015, 2015, pp.e879302. 〈10.1155/2015/879302〉</source>
<identifier>DOI : 10.1155/2015/879302</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1155/2015/879302</relation>
<identifier>PUBMED : 26425123</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/26425123</relation>
<language>en</language>
<subject>[SDV] Life Sciences [q-bio]</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>Background. In a French large population-based case-control study we investigated the dose-response relationship between lung cancer and occupational exposure to diesel motor exhaust (DME), taking into account asbestos exposure. Methods. Exposure to DME was assessed by questionnaire. Asbestos was taken into account through a global indicator of exposure to occupational carcinogens or by a specific JEM. Results. We found a crude dose response relationship with most of the indicators of DME exposure, including with the cumulative exposure index. All results were affected by adjustment for asbestos exposure. The dose response relationships between DME and lung cancer were observed among subjects never exposed to asbestos. Conclusions. Exposure to DME and to asbestos is frequently found among the same subjects, which may explain why dose-response relationships in previous studies that adjusted for asbestos exposure were inconsistent.</description>
<date>2015</date>
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