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<title lang=en>Occurrence and toxicity of disinfection byproducts in European drinking waters in relation with the HIWATE epidemiology study.</title>
<creator>Jeong, Clara H</creator>
<creator>Wagner, Elizabeth D</creator>
<creator>Siebert, Vincent R</creator>
<creator>Anduri, Sridevi</creator>
<creator>Richardson, Susan D</creator>
<creator>Daiber, Eric J</creator>
<creator>Mckague, A Bruce</creator>
<creator>Kogevinas, Manolis</creator>
<creator>Villanueva, Cristina M</creator>
<creator>Goslan, Emma H</creator>
<creator>Luo, Wentai</creator>
<creator>Isabelle, Lorne M</creator>
<creator>Pankow, James F</creator>
<creator>Grazuleviciene, Regina</creator>
<creator>Cordier, Sylvaine</creator>
<creator>Edwards, Susan C</creator>
<creator>Righi, Elena</creator>
<creator>Nieuwenhuijsen, Mark J</creator>
<creator>Plewa, Michael J</creator>
<contributor>IMIM-Hospital del Mar ; Generalitat de Catalunya</contributor>
<contributor>Center for Research in Environmental Epidemiology (CREAL) ; Universitat Pompeu Fabra [Barcelona] - Catalunya ministerio de salud</contributor>
<contributor>School of Water Science ; Cranfield University</contributor>
<contributor>Vytautas Magnus University ; Vytautas Magnus University</contributor>
<contributor>Institut de recherche, santé, environnement et travail [Rennes] (Irset) ; Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor>
<contributor>Department of Public Health Sciences ; University of Modena and Reggio Emilia</contributor>
<description>International audience</description>
<source>ISSN: 0013-936X</source>
<source>EISSN: 1520-5851</source>
<source>Environmental Science and Technology</source>
<publisher>American Chemical Society</publisher>
<identifier>hal-00875923</identifier>
<identifier>https://hal.archives-ouvertes.fr/hal-00875923</identifier>
<source>https://hal.archives-ouvertes.fr/hal-00875923</source>
<source>Environmental Science and Technology, American Chemical Society, 2012, 46 (21), pp.12120-8. 〈10.1021/es3024226〉</source>
<identifier>DOI : 10.1021/es3024226</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1021/es3024226</relation>
<identifier>PUBMED : 22958121</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/22958121</relation>
<language>en</language>
<subject>[SDV.TOX] Life Sciences [q-bio]/Toxicology</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>The HIWATE (Health Impacts of long-term exposure to disinfection byproducts in drinking WATEr) project was a systematic analysis that combined the epidemiology on adverse pregnancy outcomes and other health effects with long-term exposure to low levels of drinking water disinfection byproducts (DBPs) in the European Union. The present study focused on the relationship of the occurrence and concentration of DBPs with in vitro mammalian cell toxicity. Eleven drinking water samples were collected from five European countries. Each sampling location corresponded with an epidemiological study for the HIWATE program. Over 90 DBPs were identified; the range in the number of DBPs and their levels reflected the diverse collection sites, different disinfection processes, and the different characteristics of the source waters. For each sampling site, chronic mammalian cell cytotoxicity correlated highly with the numbers of DBPs identified and the levels of DBP chemical classes. Although there was a clear difference in the genotoxic responses among the drinking waters, these data did not correlate as well with the chemical analyses. Thus, the agents responsible for the genomic DNA damage observed in the HIWATE samples may be due to unresolved associations of combinations of identified DBPs, unknown emerging DBPs that were not identified, or other toxic water contaminants. This study represents the first to integrate quantitative in vitro toxicological data with analytical chemistry and human epidemiologic outcomes for drinking water DBPs.</description>
<date>2012-11-06</date>
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