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<title lang=fr>Pneumopathie induite par l'hydroxyurée. [Hydroxyurea-induced pneumonia].</title>
<creator>Girard, Anne</creator>
<creator>Ricordel, Caroline</creator>
<creator>Poullot, Elsa</creator>
<creator>Claeyssen, Valérie</creator>
<creator>Decaux, Olivier</creator>
<creator>Desrues, Benoît</creator>
<creator>Delaval, Philippe</creator>
<creator>Jouneau, Stéphane</creator>
<contributor>Service de pneumologie ; Hôpital Pontchaillou - CHU Pontchaillou [Rennes]</contributor>
<contributor>Service d'hématologie clinique ; Université de Rennes 1 (UR1) - Hôpital Pontchaillou</contributor>
<contributor>Service des urgences [Rennes] ; Université de Rennes 1 (UR1) - Hôpital Pontchaillou - CHU Pontchaillou [Rennes]</contributor>
<contributor>Service de médecine interne ; CHU Pontchaillou [Rennes]</contributor>
<contributor>Contaminants Chimiques, immunité et Inflammation ; Institut de recherche, santé, environnement et travail [Rennes] (Irset) ; Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ) - Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ) - Service de pneumologie ; Hôpital Pontchaillou - CHU Pontchaillou [Rennes] - Hôpital Pontchaillou - CHU Pontchaillou [Rennes]</contributor>
<description>International audience</description>
<source>ISSN: 0761-8425</source>
<source>Revue des Maladies Respiratoires</source>
<publisher>Elsevier Masson</publisher>
<identifier>hal-00916333</identifier>
<identifier>https://hal.archives-ouvertes.fr/hal-00916333</identifier>
<identifier>https://hal.archives-ouvertes.fr/hal-00916333/document</identifier>
<identifier>https://hal.archives-ouvertes.fr/hal-00916333/file/hydroxyurA_e_version_rA_visA_e.pdf</identifier>
<source>https://hal.archives-ouvertes.fr/hal-00916333</source>
<source>Revue des Maladies Respiratoires, Elsevier Masson, 2013, 31 (5), pp.430-434. 〈10.1016/j.rmr.2013.09.001〉</source>
<identifier>DOI : 10.1016/j.rmr.2013.09.001</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1016/j.rmr.2013.09.001</relation>
<identifier>PUBMED : 24878159</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/24878159</relation>
<language>fr</language>
<subject lang=fr>Pneumopathie médicamenteuse</subject>
<subject lang=fr>Fièvre</subject>
<subject lang=fr>Pneumopathie interstitielle</subject>
<subject lang=fr>Hydroxyurée</subject>
<subject>[SDV.MHEP.PSR] Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>Introduction: Hydroxyurea is an antimetabolite widely used in the treatment of myeloproliferative diseases. Usual side effects are mainly hematological, gastrointestinal, neurological disorders and induced-fevers. More rarely, hydroxyurea-induced pneumonitis are reported. Case report: We report a case of a patient treated for polycythemia vera. She was admitted 20 days after introduction of hydroxyurea for a high fever, productive cough and clear sputum associated with nausea. Chest CT-scan found diffuse bilateral ground-glass opacities. The microbiological investigations were negative. Symptoms disappeared few days after discontinuation of treatment. Its reintroduction led to recurrence of symptoms. Conclusion: This additional case completes the 15 cases of hydroxyurea-induced pneumonitis described in the literature. Two forms of this disease seem to exist: an acute form with fever occurring in the month following introduction of hydroxyurea; and a chronic form without fever. Even if it is uncommon, pulmonologists should be aware of this complication.</description>
<date>2013-10</date>
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