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<datestamp>2017-12-21</datestamp>
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<title lang=en>The protein expression landscape of mitosis and meiosis in diploid budding yeast</title>
<creator>Becker, Emmanuelle</creator>
<creator>Com, Emmanuelle</creator>
<creator>Lavigne, R.</creator>
<creator>Guilleux, Marie-Hélène</creator>
<creator>Evrard, Bertrand</creator>
<creator>Pineau, C.</creator>
<creator>Primig, M.</creator>
<contributor>Institut de recherche, santé, environnement et travail [Rennes] (Irset) ; Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor>
<contributor>Proteomics Core Facility (Protim) ; Université de Rennes 1 (UR1) - Plateforme Génomique Santé Biogenouest®</contributor>
<contributor>This work was in part funded by financial support provided to Michael Primig by Inserm (Avenir) and the University of Rennes 1 and to Charles Pineau by Biogenouest, IBiSA and Conseil Régional de Bretagne.</contributor>
<description>International audience</description>
<source>ISSN: 1874-3919</source>
<source>EISSN: 1876-7737</source>
<source>Journal of Proteomics</source>
<publisher>Elsevier</publisher>
<identifier>hal-01485858</identifier>
<identifier>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01485858</identifier>
<identifier>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01485858/document</identifier>
<identifier>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01485858/file/Becker%20et%20al.%20-%20The%20protein%20expression%20landscape%20of%20mitosis%20and%20me.pdf</identifier>
<source>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01485858</source>
<source>Journal of Proteomics, Elsevier, 2017, 156, pp.5-19. 〈10.1016/j.jprot.2016.12.016〉</source>
<identifier>DOI : 10.1016/j.jprot.2016.12.016</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jprot.2016.12.016</relation>
<identifier>PUBMED : 28057603</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/28057603</relation>
<language>en</language>
<subject lang=en>Budding yeast</subject>
<subject lang=en> Double stranded RNAs</subject>
<subject lang=en> Long noncoding RNAs</subject>
<subject lang=en> Meiosis</subject>
<subject lang=en> Proteome</subject>
<subject lang=en> Respiration</subject>
<subject lang=en> Sporulation</subject>
<subject lang=en> Transcriptome</subject>
<subject>[SDV.BBM.GTP] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN]</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>Saccharomyces cerevisiae is an established model organism for the molecular analysis of fundamental biological processes. The genomes of numerous strains have been sequenced, and the transcriptome and proteome ofmajor phases during the haploid and diploid yeast life cycle have been determined. However, much less is known about dynamic changes of the proteome when cells switch from mitotic growth to meiotic development. We report a quantitative protein profiling analysis of yeast cell division and differentiation based on mass spectrometry. Information about protein levels was integrated with strand-specific tiling array expression data. We identified a total of 2366 proteins in at least one condition, including 175 proteins showing a statistically significant > 5-fold change across the sample set, and 136 proteins detectable in sporulating but not respiring cells. We correlate protein expression patterns with biological processes and molecular function by Gene Ontology term enrichment, chemoprofiling, transcription interference and the formation of double stranded RNAs by overlapping sense/antisense transcripts. Our work provides initial quantitative insight into protein expression in diploid respiring and differentiating yeast cells. Critically, it associates developmentally regulated induction of antisense long noncoding RNAs and double stranded RNAs with fluctuating protein concentrations during growth and development. </description>
<date>2017</date>
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