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<datestamp>2017-12-21</datestamp>
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<publisher>HAL CCSD</publisher>
<title lang=en>Polylogarithmic equilibrium treatment of molecular aggregation and critical concentrations</title>
<creator>Michel, Denis</creator>
<creator>Ruelle, Philippe</creator>
<contributor>Institut de recherche, santé, environnement et travail [Rennes] (Irset) ; Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor>
<contributor>Institut de Recherche en Mathématiques et Physique (UCL IRMP) ; Université Catholique de Louvain (UCL)</contributor>
<description>International audience</description>
<source>PCCP : Physical chemistry chemical physics</source>
<publisher>Royal Society of Chemistry</publisher>
<identifier>hal-01565995</identifier>
<identifier>https://hal.archives-ouvertes.fr/hal-01565995</identifier>
<identifier>https://hal.archives-ouvertes.fr/hal-01565995/document</identifier>
<identifier>https://hal.archives-ouvertes.fr/hal-01565995/file/Aggregates_in_equilibrium.pdf</identifier>
<source>https://hal.archives-ouvertes.fr/hal-01565995</source>
<source>PCCP : Physical chemistry chemical physics, Royal Society of Chemistry, 2017, 19 (7), pp.5273-5284 〈10.1039/c6cp08369b〉</source>
<identifier>DOI : 10.1039/c6cp08369b</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1039/c6cp08369b</relation>
<identifier>PUBMED : 28149987</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/28149987</relation>
<language>en</language>
<subject lang=en> equilibrium</subject>
<subject lang=en>Nucleation</subject>
<subject lang=en> noncovalent polymers</subject>
<subject lang=en> aggregation</subject>
<subject lang=en> self-assembly</subject>
<subject>[CHIM.THEO] Chemical Sciences/Theoretical and/or physical chemistry</subject>
<subject>[PHYS.PHYS.PHYS-CHEM-PH] Physics [physics]/Physics [physics]/Chemical Physics [physics.chem-ph]</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>A full equilibrium treatment of molecular aggregation is presented for prototypes of 1D and 3D aggregates, with and without nucleation. By skipping complex kinetic parameters like aggregate size-dependent diffusion, the equilibrium treatment allows to predict directly time-independent quantities such as critical concentrations. The relationships between the macroscopic equilibrium constants for the different paths are first established by statistical corrections and so as to comply with the detailed balance constraints imposed by nucleation, and the composition of the mixture resulting from homogeneous aggregation is then analyzed using the polylogarithm function. Several critical concentrations are distinguished: the residual monomer concentation in equilibrium (RMC) and the critical nucleation concentration (CNC), that is the threshold concentration of total subunits necessary for initiating aggregation. When increasing the concentration of total subunits, the RMC converges more strongly to its asymptotic value, the equilibrium constant of depolymerization, for 3D aggregates and in case of nucleation. The CNC moderately depends on the number of subunits in the nucleus, but sharply increases with the difference between the equilibrium constants of polymerization and nucleation. As the RMC and CNC can be numerically but not analytically determined, ansatz equations connecting them to thermodynamic parameters are proposed</description>
<date>2017</date>
<rights>info:eu-repo/semantics/OpenAccess</rights>
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