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<title lang=en>Phorbol ester-modulation of estrogenic genomic effects triggered by the environmental contaminant benzanthracene.</title>
<creator>Kolasa, Elise</creator>
<creator>Balaguer, Patrick</creator>
<creator>Houlbert, Noémie</creator>
<creator>FARDEL, Olivier</creator>
<contributor>Institut de recherche, santé, environnement et travail [Rennes] (Irset) ; Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor>
<contributor>Institut de recherche en cancérologie de Montpellier (IRCM) ; Université Montpellier 1 (UM1) - CRLCC Val d'Aurelle - Paul Lamarque - Institut National de la Santé et de la Recherche Médicale (INSERM) - Université de Montpellier (UM)</contributor>
<contributor>Contaminants Chimiques, immunité et Inflammation ; Institut de recherche, santé, environnement et travail [Rennes] (Irset) ; Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ) - Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ) - Pôle biolobie ; Université de Rennes 1 (UR1) - Hôpital Pontchaillou - CHU Pontchaillou [Rennes] - Hôpital Pontchaillou - CHU Pontchaillou [Rennes]</contributor>
<contributor>Programme National de Recherche sur les Perturbateurs Endocriniens (PNRPE) from the French Minister of Ecology</contributor>
<description>International audience</description>
<source>ISSN: 0887-2333</source>
<source>Toxicology in Vitro</source>
<publisher>Elsevier</publisher>
<identifier>inserm-00872862</identifier>
<identifier>http://www.hal.inserm.fr/inserm-00872862</identifier>
<source>http://www.hal.inserm.fr/inserm-00872862</source>
<source>Toxicology in Vitro, Elsevier, 2012, 26 (6), pp.807-16. 〈10.1016/j.tiv.2012.05.006〉</source>
<identifier>DOI : 10.1016/j.tiv.2012.05.006</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1016/j.tiv.2012.05.006</relation>
<identifier>PUBMED : 22643241</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/22643241</relation>
<language>en</language>
<subject lang=en>Benzanthracene</subject>
<subject lang=en>Phorbol ester</subject>
<subject lang=en>Estrogen</subject>
<subject lang=en>Modulation</subject>
<subject lang=en>pS2</subject>
<subject lang=en>Protein kinase C</subject>
<subject>[SDV.BC] Life Sciences [q-bio]/Cellular Biology</subject>
<subject>[SDV.EE] Life Sciences [q-bio]/Ecology, environment</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>Aryl hydrocarbon receptor-dependent genomic effects of environmental polycyclic aromatic hydrocarbons (PAHs) have been shown to be modulated by non-genomic protein kinase C (PKC)-related pathways. The present study was designed to determine whether PKC activation may also impair estrogenic genomic response triggered by PAHs. Treatment by the PKC activator phorbol 12-myristate 13-acetate (PMA) was found to markedly and differentially impair the up-regulation of estrogenic markers triggered by the estrogenic PAH benzanthracene (BZA) in cultured human mammary cells; BZA-mediated mRNA up-regulation of pS2 and amphiregulin was thus increased, whereas that of progesterone receptor and CXCL12 was repressed. BZA/PMA cotreatment however failed to alter BZA-mediated increase of activity of a luciferase gene reporter construct driven by an estrogen response element, thus discarding any global effect of PMA toward BZA-triggered estrogen receptor activation. Various chemicals inhibiting PKCs or extracellular signal-regulated kinase (ERK) as well as the knock-down of PKCδ expression counteracted the PMA-mediated increase of pS2 mRNA up-regulation triggered by BZA, demonstrating that it was dependent on PKCs, including PKCδ isoform, and ERKs. This non-genomic modulation of estrogenic effects of PAHs by PKC activation may have to be considered when considering the deleterious effects of these environmental contaminants towards the endocrine system.</description>
<date>2012-09</date>
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