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<title lang=en>Prenatal pesticide exposure and otitis media during early childhood in the PELAGIE mother-child cohort</title>
<creator>Buscail, Camille</creator>
<creator>Chevrier, Cécile</creator>
<creator>Serrano, Tania</creator>
<creator>Pelé, Fabienne</creator>
<creator>Monfort, Christine</creator>
<creator>Cordier, Sylvaine</creator>
<creator>Viel, Jean-François</creator>
<contributor>Département d'Information Médicale ; Université de Rennes 1 (UR1) - Centre Hospitalier Universitaire de Rennes</contributor>
<contributor>Institut de recherche, santé, environnement et travail [Rennes] (Irset) ; Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor>
<contributor>Service de santé publique et d'épidémiologie ; CHU Pontchaillou [Rennes]</contributor>
<description>International audience</description>
<source>Occupational and Environmental Medicine</source>
<identifier>hal-01201944</identifier>
<identifier>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01201944</identifier>
<source>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01201944</source>
<source>Occupational and Environmental Medicine, 2015, 72 (12), pp.837-844. 〈10.1136/oemed-2015-103039〉</source>
<identifier>DOI : 10.1136/oemed-2015-103039</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1136/oemed-2015-103039</relation>
<identifier>PUBMED : 26347056</identifier>
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<language>en</language>
<subject>[SDV] Life Sciences [q-bio]</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>OBJECTIVE: Contemporary pesticides, such as triazines or organophosphates, possess immunotoxic properties. We aimed to determine whether prenatal environmental exposure to these current-use pesticides was associated with otitis media (OM) during the first 2 years of life among children from the PELAGIE mother-child cohort. METHODS: The PELAGIE cohort enrolled 3421 women at the beginning of pregnancy in Brittany (France). At the 2-year follow-up, 1505 families completed a self-administered questionnaire, including the domestic use of pesticides and consumption of organic diet during pregnancy and occurrences of OM in the child. Two health outcomes were considered: at least one OM and recurrent OM (at least three). Multivariate logistic regression models that adjusted for known risk factors of OM were performed. Metabolites of triazine herbicides and organophosphate insecticides measured in urine collected before the 19th week of gestation (248 mothers) were considered in a subgroup analysis. Multiple imputation was used to handle missing values for the covariates. RESULTS: Children whose mothers reported an organic diet during pregnancy had a reduced risk of OM (at least one episode, p trend=0.01). No association was found between any outcome and residential proximity to crops. The presence in maternal urine of dealkylated triazine metabolites (OR=2.12 (1.01 to 4.47)) was positively associated with recurrent OM. CONCLUSIONS: To the best of our knowledge, this is the first work to suggest a positive association between prenatal exposure to current-use pesticides and the occurrence of parent-reported OM in young children</description>
<date>2015</date>
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