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<title lang=en>Prenatal stress and early-life exposure to fluoxetine have enduring effects on anxiety and hippocampal BDNF gene expression in adult male offspring</title>
<creator>Boulle, Fabien</creator>
<creator>Pawluski, Jodi L.</creator>
<creator>Homberg, Judith R.</creator>
<creator>Machiels, Barbie</creator>
<creator>Kroeze, Yvet</creator>
<creator>Kumar, Neha</creator>
<creator>Steinbusch, Harry W. M.</creator>
<creator>Kenis, Gunter</creator>
<creator>Hove, Daniel L. A, </creator>
<contributor>Maastricht University [Maastricht]</contributor>
<contributor>Centre de Psychiatrie et Neurosciences (CPN - U894) ; Université Paris Descartes - Paris 5 (UPD5) - Institut National de la Santé et de la Recherche Médicale (INSERM)</contributor>
<contributor>Neurophysiology Unit, GIGA Neurosciences ; Université de Liège</contributor>
<contributor>Institut de recherche, santé, environnement et travail [Rennes] (Irset) ; Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor>
<contributor>Donders Institute for Brain, Cognition and Behaviour ; Radboud university [Nijmegen]</contributor>
<contributor>University of Wuerzburg ; Universität Würzburg</contributor>
<contributor>JLP was funded by a Charge de Recherche position with Fonds de la Recherche Scientifique (FRS-FNRS).</contributor>
<description>International audience</description>
<source>ISSN: 0012-1630</source>
<source>EISSN: 1098-2302</source>
<source>Developmental Psychobiology</source>
<publisher>Wiley</publisher>
<identifier>hal-01305478</identifier>
<identifier>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01305478</identifier>
<identifier>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01305478/document</identifier>
<identifier>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01305478/file/Developmental%20SSRIs%2C%20anxiety%20and%20BDNF_accepted.pdf</identifier>
<source>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01305478</source>
<source>Developmental Psychobiology, Wiley, 2016, 58 (4), pp.427--438. 〈10.1002/dev.21385〉</source>
<identifier>DOI : 10.1002/dev.21385</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1002/dev.21385</relation>
<identifier>PUBMED : 26608001</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/26608001</relation>
<language>en</language>
<subject lang=en> TrkB</subject>
<subject lang=en> prenatal stress</subject>
<subject lang=en> SEX DIFFERENCES</subject>
<subject lang=en> SSRI</subject>
<subject lang=en>BDNF</subject>
<subject lang=en> depression</subject>
<subject lang=en> Hippocampus</subject>
<subject lang=en> Neuroplasticity</subject>
<subject>[SDV.NEU.NB] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology</subject>
<subject>[SDV.NEU.PC] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Psychology and behavior</subject>
<subject>[SDV.BDD.EO] Life Sciences [q-bio]/Development Biology/Embryology and Organogenesis</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>With the growing use of selective serotonin reuptake inhibitor medications (SSRIs) for the treatment of depression during the perinatal period, questions have been raised about the longterm impact of these medications on development. We aimed to investigate how developmental SSRI exposure may alter affect-related behaviors and associated molecular processes in offspring using a rodent model of maternal stress and depression. For this purpose, prenatally stressed or non-stressed male offspring were exposed to fluoxetine (5 mg/kg/day) or vehicle, via lactation, until weaning. Primary results show that postnatal fluoxetine exposure differentially altered anxiety-like behavior by increasing anxiety in non-stressed offspring and decreasing anxiety in prenatally stressed offspring. In the hippocampus, developmental fluoxetine exposure decreased BDNF IV and TrkB mRNA expression. Prenatal stress alone also decreased escape behaviors and decreased hippocampal BDNF IV mRNA expression. These data provide important evidence for the long-term programming effects of early-life exposure to SSRIs on brain and behavior. </description>
<date>2016-05</date>
</dc>
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