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<publisher>HAL CCSD</publisher>
<title lang=en>Perinatal exposure to chlordecone, thyroid hormone status and neurodevelopment in infants: The Timoun cohort study in Guadeloupe (French West Indies).</title>
<creator>Cordier, Sylvaine</creator>
<creator>Bouquet, Emilie</creator>
<creator>Warembourg, Charline</creator>
<creator>Massart, Catherine</creator>
<creator>Rouget, Florence</creator>
<creator>Kadhel, Philippe</creator>
<creator>Bataille, Henri</creator>
<creator>Monfort, Christine</creator>
<creator>Boucher, Olivier</creator>
<creator>Muckle, Gina</creator>
<creator>Multigner, Luc</creator>
<contributor>Institut de recherche, santé, environnement et travail [Rennes] (Irset) ; Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor>
<contributor>Centre d'Investigation Clinique [Rennes] (CIC) ; Université de Rennes 1 (UR1) - Hôpital Pontchaillou - Institut National de la Santé et de la Recherche Médicale (INSERM)</contributor>
<contributor>CHU de la Martinique</contributor>
<contributor>Centre hospitalier universitaire de Québec (CHUQ) ; Centre Hospitalier Universitaire de Québec</contributor>
<contributor>Axe santé des populations et pratiques optimales en santé ; Centre de recherche du Centre Hospitalier Universitaire de Québec ; CHU Québec - CHU Québec - École de psychologie ; Université Laval - Université Laval</contributor>
<description>International audience</description>
<source>ISSN: 0013-9351</source>
<source>EISSN: 1096-0953</source>
<source>Environmental Research</source>
<publisher>Elsevier</publisher>
<identifier>hal-01134317</identifier>
<identifier>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01134317</identifier>
<identifier>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01134317/document</identifier>
<identifier>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01134317/file/Perinatal%20exposure%20to%20chlordecone_accepted.pdf</identifier>
<source>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01134317</source>
<source>Environmental Research, Elsevier, 2015, 138C, pp.271-278. 〈10.1016/j.envres.2015.02.021〉</source>
<identifier>PUBMED : 25747818</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/25747818</relation>
<identifier>DOI : 10.1016/j.envres.2015.02.021</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1016/j.envres.2015.02.021</relation>
<language>en</language>
<subject>[SDV] Life Sciences [q-bio]</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>Perinatal exposure to endocrine-disrupting chemicals may affect thyroid hormones homeostasis and impair brain development. Chlordecone, an organochlorine insecticide widely used in the French West Indies has known estrogenic and progestin properties, but no data is available, human or animal, on its action on thyroid hormone system. Our aim was to evaluate the impact of perinatal exposure to chlordecone on the thyroid hormone system of a sample of infants from the Timoun mother-child cohort in Guadeloupe and their further neurodevelopment. Chlordecone was measured in cord blood and breast milk samples. Thyroid stimulating hormone (TSH), free tri-iodothyronine (FT3), free thyroxine (FT4) were determined in child blood at 3 months (n=111). Toddlers were further assessed at 18 months using an adapted version of the Ages and Stages Questionnaire (ASQ). Cord chlordecone was associated with an increase in TSH in boys, whereas postnatal exposure was associated with a decrease in FT3 overall, and in FT4 among girls. Higher TSH level at 3 months was positively associated with the ASQ score of fine motor development at 18 months among boys, but TSH did not modify the association between prenatal chlordecone exposure and poorer ASQ fine motor score. Perinatal exposure to chlordecone may affect TSH and thyroid hormone levels at 3 months, differently according to the sex of the infant. This disruption however did not appear to intervene in the pathway between prenatal chlordecone exposure and fine motor child development.</description>
<date>2015-03-03</date>
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