untitled
<OAI-PMH schemaLocation=http://www.openarchives.org/OAI/2.0/ http://www.openarchives.org/OAI/2.0/OAI-PMH.xsd>
<responseDate>2018-01-15T18:31:21Z</responseDate>
<request identifier=oai:HAL:hal-01118572v1 verb=GetRecord metadataPrefix=oai_dc>http://api.archives-ouvertes.fr/oai/hal/</request>
<GetRecord>
<record>
<header>
<identifier>oai:HAL:hal-01118572v1</identifier>
<datestamp>2017-12-21</datestamp>
<setSpec>type:ART</setSpec>
<setSpec>subject:sdv</setSpec>
<setSpec>collection:UNIV-RENNES1</setSpec>
<setSpec>collection:IRSET</setSpec>
<setSpec>collection:UNIV-AG</setSpec>
<setSpec>collection:IFR140</setSpec>
<setSpec>collection:IRSET-ERD</setSpec>
<setSpec>collection:BIOSIT</setSpec>
<setSpec>collection:UR1-UFR-SVE</setSpec>
<setSpec>collection:STATS-UR1</setSpec>
<setSpec>collection:UR1-SDV</setSpec>
<setSpec>collection:UR1-HAL</setSpec>
<setSpec>collection:EHESP</setSpec>
<setSpec>collection:USPC</setSpec>
<setSpec>collection:IRSET-9</setSpec>
<setSpec>collection:UNIV-ANGERS</setSpec>
<setSpec>collection:IRSET-EHESP</setSpec>
</header>
<metadata><dc>
<publisher>HAL CCSD</publisher>
<title lang=en>Prenatal exposure to PCB-153, p,p'-DDE and birth outcomes in 9000 mother-child pairs: exposure-response relationship and effect modifiers.</title>
<creator>Casas, Maribel</creator>
<creator>Nieuwenhuijsen, Mark</creator>
<creator>Martínez, David</creator>
<creator>Ballester, Ferran</creator>
<creator>Basagaña, Xavier</creator>
<creator>Basterrechea, Mikel</creator>
<creator>Chatzi, Leda</creator>
<creator>Chevrier, Cécile</creator>
<creator>Eggesbø, Merete</creator>
<creator>Fernandez, Mariana F</creator>
<creator>Govarts, Eva</creator>
<creator>Guxens, Mònica</creator>
<creator>Grimalt, Joan O</creator>
<creator>Hertz-Picciotto, Irva</creator>
<creator>Iszatt, Nina</creator>
<creator>Kasper-Sonnenberg, Monika</creator>
<creator>Kiviranta, Hannu</creator>
<creator>Kogevinas, Manolis</creator>
<creator>Palkovicova, Lubica</creator>
<creator>Ranft, Ulrich</creator>
<creator>Schoeters, Greet</creator>
<creator>Patelarou, Evridiki</creator>
<creator>Petersen, Maria Skaalum</creator>
<creator>Torrent, Maties</creator>
<creator>Trnovec, Tomas</creator>
<creator>Valvi, Damaskini</creator>
<creator>Toft, Gunnar Vase</creator>
<creator>Weihe, Pál</creator>
<creator>Weisglas-Kuperus, Nynke</creator>
<creator>Wilhelm, Michael</creator>
<creator>Wittsiepe, Jürgen</creator>
<creator>Vrijheid, Martine</creator>
<creator>Bonde, Jens Peter</creator>
<contributor>Epidemiologia Ambiental ; Centre for Research in Environmental Epidemiology (CREAL) - Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP) of Pamplona - Institut Hospital del Mar d'Investigacions Mèdiques (IMIM)</contributor>
<contributor>IMIM-Hospital del Mar ; Generalitat de Catalunya</contributor>
<contributor>Center for Research in Environmental Epidemiology (CREAL) ; Universitat Pompeu Fabra [Barcelona] - Catalunya ministerio de salud</contributor>
<contributor>Institut de recherche, santé, environnement et travail [Rennes] (Irset) ; Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor>
<contributor>Division of Epidemiology ; Norwegian Institute of Public Health</contributor>
<contributor>Department of Public Health Sciences ; University of California, Davis-Livermore</contributor>
<contributor>Department of Epidemiology and Public Health ; Imperial College London</contributor>
<contributor>Department of Environmental Heath ; National Institute for Health and Welfare,</contributor>
<contributor>Department of Social Medicine ; University of Crete (UOC) - Medical School</contributor>
<contributor>School of Public Health ; University of California [Berkeley]</contributor>
<contributor>Slovak Medical University ; Slovak Medical University</contributor>
<contributor>Department of Occupational Medicine ; Aarhus University Hospital</contributor>
<contributor>Department of Occupational Medicines and Public Health ; The Faroese Hospital System (Landssjúkrahúsið) (LS)</contributor>
<contributor>Department of Occupational and Environmental Medicine ; Bispebjerg University Hospital</contributor>
<description>International audience</description>
<source>ISSN: 0160-4120</source>
<source>Environment International</source>
<publisher>Elsevier</publisher>
<identifier>hal-01118572</identifier>
<identifier>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01118572</identifier>
<source>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01118572</source>
<source>Environment International, Elsevier, 2014, 74, pp.23-31. 〈10.1016/j.envint.2014.09.013〉</source>
<identifier>PUBMED : 25314142</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/25314142</relation>
<identifier>DOI : 10.1016/j.envint.2014.09.013</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1016/j.envint.2014.09.013</relation>
<language>en</language>
<subject>[SDV] Life Sciences [q-bio]</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>Low-level exposure to polychlorinated biphenyl-153 (PCB-153) and dichlorodiphenyldichloroethylene (p-p'-DDE) can impair fetal growth; however, the exposure-response relationship and effect modifiers of such association are not well established. This study is an extension of an earlier European meta-analysis. Our aim was to explore exposure-response relationship between PCB-153 and p-p'-DDE and birth outcomes; to evaluate whether any no exposure-effect level and susceptible subgroups exist; and to assess the role of maternal gestational weight gain (GWG). We used a pooled dataset of 9377 mother-child pairs enrolled in 14 study populations from 11 European birth cohorts. General additive models were used to evaluate the shape of the relationships between organochlorine compounds and birth outcomes. We observed an inverse linear exposure-response relationship between prenatal exposure to PCB-153 and birth weight [decline of 194g (95% CI -314, -74) per 1μg/L increase in PCB-153]. We showed effects on birth weight over the entire exposure range, including at low levels. This reduction seems to be stronger among children of mothers who were non-Caucasian or had smoked during pregnancy. The most susceptible subgroup was girls whose mothers smoked during pregnancy. After adjusting for absolute GWG or estimated fat mass, a reduction in birth weight was still observed. This study suggests that the association between low-level exposure to PCB-153 and birth weight exists and follows an inverse linear exposure-response relationship with effects even at low levels, and that maternal smoking and ethnicity modify this association.</description>
<date>2014-12-31</date>
</dc>
</metadata>
</record>
</GetRecord>
</OAI-PMH>
