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<datestamp>2018-01-09</datestamp>
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<publisher>HAL CCSD</publisher>
<title lang=en>Performance Testing of PCR Assay in Blood Samples for the Diagnosis of Toxoplasmic Encephalitis in AIDS Patients from the French Departments of America and Genetic Diversity of Toxoplasma gondii: A Prospective and Multicentric Study</title>
<creator>Ajzenberg, Daniel</creator>
<creator>Lamaury, Isabelle</creator>
<creator>Demar, Magalie</creator>
<creator>Vautrin, Cyrille</creator>
<creator>Cabié, André</creator>
<creator>Simon, Stéphane</creator>
<creator>Nicolas, Muriel</creator>
<creator>Desbois-Nogard, Nicole</creator>
<creator>Boukhari, Rachida</creator>
<creator>Riahi, Homayoun</creator>
<creator>Dardé, Marie-Laure</creator>
<creator>Massip, Patrice</creator>
<creator>Dupon, Michel</creator>
<creator>Preux, Pierre-Marie</creator>
<creator>Labrunie, Anaïs</creator>
<creator>Boncoeur-Martel, Marie Paule</creator>
<contributor>Neuroépidémiologie Tropicale (NET) ; Institut National de la Santé et de la Recherche Médicale (INSERM) - Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST FR CNRS 3503) - Institut d'Epidémiologie Neurologique et de Neurologie Tropicale - CHU Limoges - Université de Limoges (UNILIM)</contributor>
<contributor>Université de Limoges (UNILIM)</contributor>
<contributor>Centre National de Référence (CNR) Toxoplasmose/Toxoplasma Biological Resource Center (BRC) (CNR Toxoplasmose-Toxoplasma BRC) ; CHU Limoges</contributor>
<contributor>Service des maladies infectieuses ; CHU de Pointe-à-Pitre/Abymes</contributor>
<contributor>Laboratoire Hospitalo-Universitaire de Parasitologie-Mycologie [Cayenne, Guyane Française] ; Centre Hospitalier de Cayenne Andrée Rosemon - Coordination Régionale de la lutte contre le Virus de L'Immunodéficience Humaine (COREVIH)</contributor>
<contributor> Écosystèmes amazoniens et pathologie tropicale [Cayenne, Guyane Française] ; Université de Guyane (UG)</contributor>
<contributor>Service de Médecine ; Centre Hospitalier de l'Ouest Guyanais Franck Joly (Saint-Laurent-du-Maroni) </contributor>
<contributor>Service de Maladies Infectieuses et Tropicales [Fort-de-France, Martinique] ; CHU de la Martinique - Hôpital Pierre Zobda-Quitman [CHU de la Martinique] ; CHU de la Martinique - Centre Hospitalier Universitaire de Fort de France</contributor>
<contributor>Centre d'Investigation Clinique Antilles-Guyane (CIC - Antilles Guyane) ; Université des Antilles et de la Guyane (UAG) - Institut National de la Santé et de la Recherche Médicale (INSERM) - CHU de Pointe-à-Pitre - Centre Hospitalier de Cayenne Andrée Rosemon - CHU de Fort de France</contributor>
<contributor> Laboratoire de Microbiologie ; Centre Hospitalier Universitaire de Pointe à Pitre</contributor>
<contributor>Laboratoire de Biologie Médicale ; Centre Hospitalier de l'Ouest Guyanais Franck Joly (Saint-Laurent-du-Maroni)</contributor>
<contributor>Service de Biologie Médicale ; Centre Hospitalier de l'Ouest Guyanais</contributor>
<contributor>Service des maladies infectieuses et tropicales[Toulouse] ; Université Paul Sabatier - Toulouse 3 (UPS) - CHU Toulouse [Toulouse] - Hôpital Purpan [Toulouse]</contributor>
<contributor>Service des maladies infectieuses ; CHU Bordeaux [Bordeaux] - Groupe hospitalier Pellegrin</contributor>
<contributor>Laboratoire de Biostatistique et d'Informatique Médicale ; Université de Limoges (UNILIM)</contributor>
<contributor>Service de l'Information Médicale et de l'Évaluation [CHU Limoges] (SIME) ; CHU Limoges</contributor>
<contributor>Service de Neuroradiologie interventionnelle [CHU Limoges] ; CHU Limoges</contributor>
<contributor>French Ministry of Health (PHRC R 2007- R-04)</contributor>
<description>International audience</description>
<source>ISSN: 1935-2727</source>
<source>EISSN: 1935-2735</source>
<source>PLoS Neglected Tropical Diseases</source>
<publisher>Public Library of Science</publisher>
<identifier>hal-01503761</identifier>
<identifier>https://hal-unilim.archives-ouvertes.fr/hal-01503761</identifier>
<identifier>https://hal-unilim.archives-ouvertes.fr/hal-01503761/document</identifier>
<identifier>https://hal-unilim.archives-ouvertes.fr/hal-01503761/file/journal.pntd.0004790.pdf</identifier>
<source>https://hal-unilim.archives-ouvertes.fr/hal-01503761</source>
<source>PLoS Neglected Tropical Diseases, Public Library of Science, 2016, 10 (6), pp.e0004790. 〈10.1371/journal.pntd.0004790〉</source>
<identifier>DOI : 10.1371/journal.pntd.0004790</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pntd.0004790</relation>
<language>en</language>
<subject lang=en>Toxoplasmic encephalitis</subject>
<subject lang=en>AIDS</subject>
<subject lang=en>Caribbean</subject>
<subject lang=en>Toxoplasma gondii</subject>
<subject lang=en>Brazil</subject>
<subject lang=en>South America</subject>
<subject>[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>Diagnosis of toxoplasmic encephalitis (TE) in patients with AIDS is not straightforward because clinicians rely initially on an empiric diagnosis based on clinical and radiographic improvement to specific anti-Toxoplasma gondii therapy. There is therefore a need for biological tools to improve the diagnosis of TE, especially in tropical areas where this diagnosis is likely to be underestimated. The use of PCR testing in blood samples for the diagnosis of TE has been limited by its poor sensitivity in the studies conducted in Europe. In tropical South America, the results of PCR sensitivity in blood samples were controversial. Considering that T. gondii strains from tropical South America have substantial genetic and pathogenic differences with those from USA and Europe, it is therefore important to re-evaluate the performance of the PCR assay in blood samples for the diagnosis of TE in AIDS patients from this region. Our results showed that the only interest of PCR would be in the most severe forms of TE with altered consciousness because PCR is more likely to be positive. We also provided important genotyping data on T. gondii strains isolated in human cases of toxoplasmosis in the Caribbean and in South America.</description>
<contributor>ClinicalTrials.gov NCT00803621</contributor>
<date>2016-06-29</date>
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