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<datestamp>2018-01-11</datestamp>
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<publisher>HAL CCSD</publisher>
<title lang=en>Polymorphism of the merozoite surface protein-1 block 2 region in Plasmodium falciparum isolates from Mauritania.</title>
<creator>Ahmedou Salem, Mohamed Salem</creator>
<creator>Ndiaye, Magatte</creator>
<creator>OuldAbdallahi, Mohamed</creator>
<creator>Lekweiry, Khadijetou</creator>
<creator>Bogreau, Hervé</creator>
<creator>Konaté, Lassana</creator>
<creator>Faye, Babacar</creator>
<creator>Gaye, Oumar</creator>
<creator>Faye, Ousmane</creator>
<creator>Mohamed Salem O Boukhary, Ali</creator>
<contributor>Laboratoire de Biotechnologie ; Université des Sciences, de Technologie et de Médecine - Faculté des Sciences et Techniques</contributor>
<contributor>Laboratoire d'Ecologie Vectorielle et Parasitaire ; Université Cheikh Anta Diop (UCAD) - Faculté des Sciences et Techniques</contributor>
<contributor>Service de Parasitologie et de Mycologie [Dakar] ; Université Cheikh Anta Diop (UCAD)</contributor>
<contributor>Service de Parasitologie et de Mycologie [Nouakchott] ; Institut National de Recherches en Santé Publique</contributor>
<contributor>Unité de Parasitologie [Brétigny] ; Institut de Recherche Biomédicale des Armées (IRBA)</contributor>
<contributor>Unité de Parasitologie [Cayenne] ; Université des Antilles et de la Guyane (UAG) - Institut Pasteur de la Guyane</contributor>
<contributor>Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes (URMITE) ; Centre National de la Recherche Scientifique (CNRS) - IFR48 - Institut National de la Santé et de la Recherche Médicale (INSERM) - Aix Marseille Université (AMU) - Institut de Recherche pour le Développement (IRD)</contributor>
<contributor>This study was supported by the national malaria control program (PNLP) of Mauritania.</contributor>
<description>International audience</description>
<source>ISSN: 1475-2875</source>
<source>Malaria Journal</source>
<publisher>BioMed Central</publisher>
<identifier>inserm-00936407</identifier>
<identifier>http://www.hal.inserm.fr/inserm-00936407</identifier>
<identifier>http://www.hal.inserm.fr/inserm-00936407/document</identifier>
<identifier>http://www.hal.inserm.fr/inserm-00936407/file/1475-2875-13-26.pdf</identifier>
<source>http://www.hal.inserm.fr/inserm-00936407</source>
<source>Malaria Journal, BioMed Central, 2014, 13 (1), pp.26. 〈10.1186/1475-2875-13-26〉</source>
<identifier>DOI : 10.1186/1475-2875-13-26</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1186/1475-2875-13-26</relation>
<identifier>PUBMED : 24456636</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/24456636</relation>
<language>en</language>
<subject lang=en>Plasmodium falciparum</subject>
<subject lang=en>Malaria</subject>
<subject lang=en>Genetic diversity</subject>
<subject lang=en>Multiplicity of infection</subject>
<subject lang=en>msp-1 gene</subject>
<subject lang=en>Mauritania</subject>
<subject>[SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>BACKGROUND: The genetic diversity of Plasmodium falciparum has been extensively studied in various parts of the world. However, limited data are available from Mauritania. The present study examined and compared the genetic diversity of P. falciparum isolates in Mauritania. METHODS: Plasmodium falciparum isolates blood samples were collected from 113 patients attending health facilities in Nouakchott and Hodh El Gharbi regions. K1, Mad20 and RO33 allelic family of msp-1 gene were determined by nested PCR amplification. RESULTS: K1 family was the predominant allelic type carried alone or in association with Ro33 and Mad20 types (90%; 102/113). Out of the 113 P. falciparum samples, 93(82.3%) harboured more than one parasite genotype. The overall multiplicity of infection was 3.2 genotypes per infection. There was no significant correlation between multiplicity of infection and age of patients. A significant increase of multiplicity of infection was correlated with parasite densities. CONCLUSIONS: The polymorphism of P. falciparum populations from Mauritania was high. Infection with multiple P. falciparum clones was observed, as well as a high multiplicity of infection reflecting both the high endemicity level and malaria transmission in Mauritania.</description>
<date>2014-01-23</date>
</dc>
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