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<title lang=en>Potential of MALDI imaging for the toxicological evaluation of environmental pollutants</title>
<creator>Lagarrigue, Mélanie</creator>
<creator>Caprioli, Richard M.</creator>
<creator>Pineau, Charles</creator>
<contributor>Institut de recherche, santé, environnement et travail [Rennes] (Irset) ; Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor>
<contributor>Vanderbilt University [Nashville]</contributor>
<contributor>This work was supported by Inserm, the University of Rennes 1, the Agence Nationale de la Recherche (ANR, Contaminants et Environnements, CESA, ANR-11-CESA-0017), and in part by grants from Biogenouest, Infrastructures en Biologie Santé et Agronomie (IBiSA), Fonds Européen de Développement Régional and Conseil Régional de Bretagne. RC acknowledges funding from NIH (P41 GM103391).</contributor>
<description>International audience</description>
<source>ISSN: 1874-3919</source>
<source>EISSN: 1876-7737</source>
<source>Journal of Proteomics</source>
<publisher>Elsevier</publisher>
<identifier>hal-01367141</identifier>
<identifier>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01367141</identifier>
<identifier>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01367141/document</identifier>
<identifier>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01367141/file/Potential%20of%20MALDI%20imaging.pdf</identifier>
<source>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01367141</source>
<source>Journal of Proteomics, Elsevier, 2016, 144, pp.133--139. 〈10.1016/j.jprot.2016.05.008〉</source>
<identifier>DOI : 10.1016/j.jprot.2016.05.008</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jprot.2016.05.008</relation>
<identifier>PUBMED : 27178109</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/27178109</relation>
<language>en</language>
<subject lang=en> Environmental pollutants</subject>
<subject lang=en> MALDI</subject>
<subject lang=en> Mass spectrometry</subject>
<subject lang=en> Imaging</subject>
<subject lang=en> Toxicology</subject>
<subject>[SDE.IE] Environmental Sciences/Environmental Engineering</subject>
<subject>[CHIM.ANAL] Chemical Sciences/Analytical chemistry</subject>
<subject>[SDV.TOX.ECO] Life Sciences [q-bio]/Toxicology/Ecotoxicology</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>Risk assessment related to the exposure of humans to chemicals released into the environment is a major concern of our modern societies. In this context, toxicology plays a crucial role to characterize the effects of this exposure on health and identify the targets of these molecules. MALDI imaging mass spectrometry (IMS) is an enabling technology for biodistribution studies of chemicals. Although the majority of published studies are presented in a pharmacological context, the concepts discussed in this review can be applied to the toxicological evaluation of chemicals released into the environment. The major asset of IMS is the simultaneous localization and identification of a parent molecule and its metabolites without labeling and without any prior knowledge. Quantification methods developed in IMS are presented with application to an environmental pollutant. IMS is effective in the localization of chemicals and endogenous species. This opens unique perspectives for the discovery of molecular alterations in metabolites and protein biomarkers that could help for a better understanding of toxicity mechanisms. Distribution studies of agrochemicals in plants by IMS can contribute to a better understanding of their mode of action and to a more effective use of these chemicals, avoiding the current concern of environmental damage.</description>
<date>2016</date>
</dc>
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