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<publisher>HAL CCSD</publisher>
<title lang=en>Prenatal exposure to DDE and PCB 153 and respiratory health in early childhood: a meta-analysis</title>
<creator>Gascon, Mireia</creator>
<creator>Sunyer, Jordi</creator>
<creator>Casas, Maribel</creator>
<creator>Martínez, David</creator>
<creator>Ballester, Ferran</creator>
<creator>Basterrechea, Mikel</creator>
<creator>Bonde, Jens Peter</creator>
<creator>Chatzi, Leda</creator>
<creator>Chevrier, Cécile</creator>
<creator>Eggesbø, Merete</creator>
<creator>Esplugues, Ana</creator>
<creator>Govarts, Eva</creator>
<creator>Hannu, Kiviranta</creator>
<creator>Ibarluzea, Jesús</creator>
<creator>Kasper-Sonnenberg, Monika</creator>
<creator>Klümper, Claudia</creator>
<creator>Koppen, Gudrun</creator>
<creator>Nieuwenhuijsen, Mark J.</creator>
<creator>Palkovicova, Lubica</creator>
<creator>Pelé, Fabienne</creator>
<creator>Polder, Anuschka</creator>
<creator>Schoeters, Greet</creator>
<creator>Torrent, Maties</creator>
<creator>Trnovec, Tomas</creator>
<creator>Vassilaki, Maria</creator>
<creator>Vrijheid, Martine</creator>
<contributor>Center for Research in Environmental Epidemiology (CREAL) ; Universitat Pompeu Fabra [Barcelona] - Catalunya ministerio de salud</contributor>
<contributor>IMIM-Hospital del Mar ; Generalitat de Catalunya</contributor>
<contributor>Universitat Pompeu Fabra [Barcelona]</contributor>
<contributor>CIBER Epidemiologia y Salud Pública (CIBERESP) ; Barcelona Biomedical Research Park</contributor>
<contributor>Epidemiologia Ambiental ; Centre for Research in Environmental Epidemiology (CREAL) - Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP) of Pamplona - Institut Hospital del Mar d'Investigacions Mèdiques (IMIM)</contributor>
<contributor>Department of Preventive Medicine and Public Health ; Universidad Complutense de Madrid</contributor>
<contributor>Chercheur Indépendant</contributor>
<contributor>Department of Occupational and Environmental Medicine ; Bispebjerg University Hospital</contributor>
<contributor>Institut de recherche, santé, environnement et travail [Rennes] (Irset) ; Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor>
<contributor>Division of Epidemiology ; Norwegian Institute of Public Health</contributor>
<contributor>Environmental Risk and Health Unit ; Flemish Institute of Technological Research (VITO)</contributor>
<contributor>Flemish Institute of Technological Research ; Flemish Institute of Technological Research</contributor>
<contributor>Slovak Medical University ; Slovak Medical University</contributor>
<description>International audience</description>
<source>Epidemiology (Cambridge, Mass.)</source>
<identifier>hal-01063930</identifier>
<identifier>https://hal.archives-ouvertes.fr/hal-01063930</identifier>
<source>https://hal.archives-ouvertes.fr/hal-01063930</source>
<source>Epidemiology (Cambridge, Mass.), 2014, 25 (4), pp.544--553. 〈10.1097/EDE.0000000000000097〉</source>
<identifier>DOI : 10.1097/EDE.0000000000000097</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1097/EDE.0000000000000097</relation>
<identifier>PUBMED : 24776790</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/24776790</relation>
<language>en</language>
<subject>[SDV] Life Sciences [q-bio]</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>BACKGROUND: Persistent organic pollutants may affect the immune and respiratory systems, but available evidence is based on small study populations. We studied the association between prenatal exposure to dichlorodiphenyldichloroethylene (DDE) and polychlorinated biphenyl 153 (PCB 153) and children's respiratory health in European birth cohorts. METHODS: We included 4608 mothers and children enrolled in 10 birth cohort studies from 7 European countries. Outcomes were parent-reported bronchitis and wheeze in the first 4 years of life. For each cohort, we performed Poisson regression analyses, modeling occurrences of the outcomes on the estimates of cord-serum concentrations of PCB 153 and DDE as continuous variables (per doubling exposure) and as cohort-specific tertiles. Summary estimates were obtained through random-effects meta-analyses. RESULTS: The risk of bronchitis or wheeze (combined variable) assessed before 18 months of age increased with increasing DDE exposure (relative risk [RR] per doubling exposure = 1.03 [95% confidence interval = 1.00-1.07]). When these outcomes were analyzed separately, associations appeared stronger for bronchitis. We also found an association between increasing PCB 153 exposure and bronchitis in this period (RR per doubling exposure = 1.06 [1.01-1.12]) but not between PCB 153 and wheeze. No associations were found between either DDE or PCB 153 and ever-wheeze assessed after 18 months. Inclusion of both compounds in the models attenuated risk estimates for PCB 153 tertiles of exposure, whereas DDE associations were more robust. CONCLUSION: This large meta-analysis suggests that prenatal DDE exposure may be associated with respiratory health symptoms in young children (below 18 months), whereas prenatal PCB 153 levels were not associated with such symptoms.</description>
<date>2014</date>
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