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<title lang=en>PBPK model of methotrexate in cerebrospinal fluid ventricles using a combined microdialysis and MRI acquisition</title>
<creator>Brandhonneur, Nolwenn</creator>
<creator>Noury, Fanny</creator>
<creator>Bruyère, Arnaud</creator>
<creator>Saint-Jalmes, Hervé</creator>
<creator>Le Corre, Pascal</creator>
<contributor>Institut de recherche, santé, environnement et travail [Rennes] (Irset) ; Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor>
<contributor>Laboratoire Traitement du Signal et de l'Image (LTSI) ; Université de Rennes 1 (UR1) - Institut National de la Santé et de la Recherche Médicale (INSERM)</contributor>
<contributor>CRLCC Eugène Marquis (CRLCC)</contributor>
<contributor>Centre Hospitalo-Universitaire de Rennes ; Pôle Pharmacie</contributor>
<description>International audience</description>
<source>ISSN: 0939-6411</source>
<source>European Journal of Pharmaceutics and Biopharmaceutics</source>
<publisher>Elsevier</publisher>
<identifier>hal-01335562</identifier>
<identifier>https://hal.archives-ouvertes.fr/hal-01335562</identifier>
<identifier>https://hal.archives-ouvertes.fr/hal-01335562/document</identifier>
<identifier>https://hal.archives-ouvertes.fr/hal-01335562/file/PBPK%20model%20of%20methotrexate%20in%20cerebrospinal%20fluid.pdf</identifier>
<source>https://hal.archives-ouvertes.fr/hal-01335562</source>
<source>European Journal of Pharmaceutics and Biopharmaceutics, Elsevier, 2016, 104, pp.117-130. 〈10.1016/j.ejpb.2016.04.012〉</source>
<identifier>DOI : 10.1016/j.ejpb.2016.04.012</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1016/j.ejpb.2016.04.012</relation>
<identifier>PUBMED : 27142258</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/27142258</relation>
<language>en</language>
<subject>[SDV.SP.PHARMA] Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology</subject>
<subject>[SDV.IB.IMA] Life Sciences [q-bio]/Bioengineering/Imaging</subject>
<subject>[SPI.SIGNAL] Engineering Sciences [physics]/Signal and Image processing</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>The objective of the study was to evaluate the distribution of methotrexate (MTX) in cerebrospinal fluid (CSF) lateral ventricles and in cisterna magna after 3rd intraventricular CSF administration in a rabbit model.MTX or gadolinium chelate (Gd-DOTA) was administered in the 3rd ventricle with a local microdialysis to study the pharmacokinetics at the site of administration and with a simultaneous magnetic resonance imaging (MRI) acquisition in the 3rd ventricle, the lateral ventricles and in the cisterna magna. A specific CSF Physiologically Based Pharmacokinetic (PBPK) model was then extrapolated for MTX from Gd-DOTA data.The relative contribution of elimination and distribution processes to the overall disposition of MTX and Gd-DOTA in the 3rd ventricle was similar (i.e., around 60% for CLE and 40% for CLI) suggesting that Gd-DOTA was a suitable surrogate marker for MTX disposition in ventricular CSF. The PBPK predictions for MTX both in CSF of the 3rd ventricle and in plasma were in accordance with the in vivo results.The present study showed that the combination of local CSF microdialysis with MRI acquisition of the brain ventricles and a PBPK model could be a useful methodology to estimate the drug diffusion within CSF ventricles after direct brain CSF administration. Such a methodology would be of interest to clinicians for a rationale determination and optimization of drug dosing parameters in the treatment of leptomeningeal metastases.</description>
<date>2016</date>
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