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<publisher>HAL CCSD</publisher>
<title lang=en>Predictive Factors of Herpes Zoster HIV-Infected Patients: Another Adverse Effect of Crack Cocaine.</title>
<creator>Nacher, Mathieu</creator>
<creator>Basurko, Celia</creator>
<creator>Adenis, Antoine</creator>
<creator>Gaubert-Marechal, Emilie</creator>
<creator>Mosnier, Emilie</creator>
<creator>Edouard, Sophie</creator>
<creator>Vantilcke, Vincent</creator>
<creator>Sivapregassam, Sindou</creator>
<creator>Tressières, Benoit</creator>
<creator>Cabié, André</creator>
<creator>Couppié, Pierre</creator>
<contributor>Centre d'investigation clinique Antilles-Guyane ; Institut National de la Santé et de la Recherche Médicale (INSERM) - CH Cayenne</contributor>
<contributor>Laboratoire Hospitalo-Universitaire de Parasitologie-Mycologie ; Centre Hospitalier de Cayenne Andrée Rosemon - Coordination Régionale de la lutte contre le Virus de L'Immunodéficience Humaine (COREVIH)</contributor>
<contributor>Epidémiologie des parasitoses et mycoses tropicales ; Université des Antilles et de la Guyane (UAG) - Institut National de la Santé et de la Recherche Médicale (INSERM)</contributor>
<contributor>Service de Dermatologie et Vénérologie ; Centre Hospitalier de Cayenne Andrée Rosemon</contributor>
<contributor>Coordination Régionale de la lutte contre le Virus de L'Immunodéficience Humaine (COREVIH Guyane) ; Centre hospitalier Andrée Rosemon (Cayenne)</contributor>
<contributor>Centre d'Investigation Clinique Epidémiologie Clinique Antilles Guyane [Fort-de-France] ; Institut National de la Santé et de la Recherche Médicale (INSERM) - Hôpital Pierre Zobda Quitman - Direction générale de l'offre de soins (DGOS) - Centre Hospitalier Universitaire de Fort de France</contributor>
<contributor>Service de Maladies Infectieuses et Tropicales ; Centre Hospitalier Universitaire de Fort de France</contributor>
<description>International audience</description>
<source>ISSN: 1932-6203</source>
<source>PLoS ONE</source>
<publisher>Public Library of Science</publisher>
<identifier>inserm-00921158</identifier>
<identifier>http://www.hal.inserm.fr/inserm-00921158</identifier>
<identifier>http://www.hal.inserm.fr/inserm-00921158/document</identifier>
<identifier>http://www.hal.inserm.fr/inserm-00921158/file/2013_Nacher_-_Predictive_factorssur herpes_zoster.pdf</identifier>
<source>http://www.hal.inserm.fr/inserm-00921158</source>
<source>PLoS ONE, Public Library of Science, 2013, 8 (11), pp.e80187. 〈10.1371/journal.pone.0080187〉</source>
<identifier>DOI : 10.1371/journal.pone.0080187</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0080187</relation>
<identifier>PUBMED : 24244647</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/24244647</relation>
<language>en</language>
<subject>[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>A retrospective cohort study was conducted on 1541 HIV-infected patients to determine variables associated with the incidence of herpes zoster. A single failure Cox model showed that herpes zoster incidence increased following the first 6 months of antiretroviral treatment adjusted hazard ratio (AHR)=5 (95%CI=2.6-9.2), P<0.001; in the >60 years age group AHR=2 (95%CI=1-4), P=0.04; in patients in the top CD8 quartile AHR=2.1 (95%CI=1.3-3.6), P<0.001; and in patients previously reported to use crack cocaine AHR=5.9, (95%CI=1.4-25), P=0.02. Herpes zoster incidence increased in patients with CD4 counts<500 per mm(3) and gradually declined since 1992-1996, with AHR=0.3 (95%CI=0.2-0.5), P<0.001 for the 1997-2002 period and AHR=0.24 (95%CI=0.14-0.4), P<0.001 for the 2002-2008 period. Contrary to what has been described elsewhere, there was no specific effect of protease inhibitors on herpes zoster incidence. The present study is the first to suggest that crack cocaine is associated with an increased incidence of herpes zoster. The neurological or immunological effects of crack are discussed.</description>
<date>2013</date>
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