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<datestamp>2017-12-21</datestamp>
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<publisher>HAL CCSD</publisher>
<title lang=en>Parallel assessment of the effects of bisphenol A and several of its analogs on the adult human testis</title>
<creator>Desdoits-Lethimonier, Christèle</creator>
<creator>Lesné, Lauriane</creator>
<creator>Gaudriault, Pierre</creator>
<creator>Zalko, Daniel</creator>
<creator>Antignac, Jean-Philippe</creator>
<creator>Deceuninck, Yoann</creator>
<creator>Platel, Christian</creator>
<creator>Dejucq-Rainsford, Nathalie</creator>
<creator>Mazaud-Guittot, Séverine</creator>
<creator>Jégou, Bernard</creator>
<contributor>Institut de recherche, santé, environnement et travail [Rennes] (Irset) ; Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor>
<contributor>ToxAlim (ToxAlim) ; Institut National Polytechnique [Toulouse] (INP) - Institut National de la Recherche Agronomique (INRA) - Université Paul Sabatier - Toulouse 3 (UPS) - Ecole Nationale Vétérinaire de Toulouse</contributor>
<contributor>LABERCA ; ONIRIS</contributor>
<contributor>CHU Pontchaillou [Rennes]</contributor>
<contributor>Inserm (Institut National de la Sante et de la Recherche Medicale)</contributor>
<contributor> EHESP-School of Public Health, University of Rennes 1 (Universite de Rennes 1)</contributor>
<contributor> Agence Nationale de la Recherche (ANR) [ANR-13-CESA-0012-03 NEWPLAST]</contributor>
<contributor> Agence Nationale de Securite Sanitaire de l'Alimentation, de l'Environnement et du Travail (ANSES) [EST-2010/2/046 (BPATESTIS)]</contributor>
<description>International audience</description>
<source>ISSN: 0268-1161</source>
<source>EISSN: 1460-2350</source>
<source>Human Reproduction</source>
<publisher>Oxford University Press (OUP)</publisher>
<identifier>hal-01578582</identifier>
<identifier>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01578582</identifier>
<identifier>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01578582/document</identifier>
<identifier>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01578582/file/Parallel%20assessment%20of%20the%20effects%20of%20bisphenol%20A_accepted.pdf</identifier>
<source>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01578582</source>
<source>Human Reproduction, Oxford University Press (OUP), 2017, 32 (7), pp.1465--1473. 〈10.1093/humrep/dex093〉</source>
<identifier>DOI : 10.1093/humrep/dex093</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1093/humrep/dex093</relation>
<identifier>PUBMED : 28482050</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/28482050</relation>
<language>en</language>
<subject lang=en>bisphenols</subject>
<subject lang=en> anti-androgenic compounds</subject>
<subject lang=en> reproductive function</subject>
<subject lang=en> endocrine disruptor</subject>
<subject lang=en> human testis</subject>
<subject lang=en> leydig cells</subject>
<subject lang=en> sertoli cells</subject>
<subject lang=en> testosterone</subject>
<subject lang=en> insulin-like factor 3</subject>
<subject lang=en> inhibin b</subject>
<subject>[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>Are bisphenol A (BPA) and BPA analogs (BPA-A) safe for male human reproductive function? The endocrine function of human testes explants [assessed by measuring testosterone and insulin-like factor 3 (INSL3)] was impacted by exposure of the human adult testis explants to BPA/BPA-A. The few epidemiologic studies performed suggest that bisphenols have potential endocrine disruptive properties, but they did not identify clear and direct patterns of endocrine disruption. Adult human testis explants in culture were exposed to BPA and the analogs bisphenol F (BPF), bisphenol S (BPS), bisphenol E (BPE), bisphenol B (BPB) and bisphenol A diglycidyl ether (BADGE) at 10(-9)-10(-5) M for 24 or 48 h. Human adult testes were obtained from prostate cancer patients who had no hormone therapy, or from multiorgan donors. After ex vivo exposure to the investigated bisphenols, the measured outcomes were related to histopathology (gross morphology and germ cell viability determined by anti-caspase three immunohistochemistry), and the levels of testosterone, INSL3 and inhibin B were measured using immunoassays. The levels of mRNA encoding key enzymes of bisphenol biotransformation were investigated by quantitative PCR: UGT2B15 UDP (glucuronosyltransferase two family, polypeptide B15), GUSB (glucuronidase beta), SULT1A1 and 3 (sulfotransferase family 1 A member 1 and 3) and STS (steroid sulfatase). A significant dose-dependent inhibition was found between testosterone levels measured in the culture medium and concentrations of BPA (P = 0.00778 at 24 h and P = 0.0291 at 48 h), BPE (P = 0.039) and BPF (P = 0.00663). The observed BPA and BPA-A-induced inhibition of testosterone production varied according to duration of exposure and BPA/BPA-A concentrations. BPA (10(-9) M; P < 0.05), BPB (10(-9) M; P < 0.05), BPS (10(-9) and 10(-8) M; P < 0.05) and BADGE (10(-5) M; P < 0.05) increased Leydig cell INSL3 production. By contrast, BPE dose dependently inhibited INSL3 (P = 0.0372). Conversely, Sertoli cell function (inhibin B) and germ cell viability were not significantly affected by either bisphenols. N/A. Environmental compounds cannot be deliberately administered to men, justifying the use of an ex vivo approach. A relatively low number of testes samples were available for analysis (n = 3, except for testosterone secretion with n = 5). The active concentrations of BPA and BPA-A used in the study were higher than those found in human biological fluids. Under our experimental conditions, direct exposure to BPA or BPA-A can result in endocrine disturbance in the adult human testis.</description>
<date>2017-07</date>
</dc>
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