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<identifier>oai:HAL:hal-00877955v1</identifier>
<datestamp>2014-10-28</datestamp>
<setSpec>type:ART</setSpec>
<setSpec>subject:sdv</setSpec>
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<publisher>HAL CCSD</publisher>
<title lang=en>Reproductive impacts of tributyltin (TBT) and triphenyltin (TPT) in the hermaphroditic freshwater gastropod Lymnaea stagnalis.</title>
<creator>Giusti, Arnaud</creator>
<creator>Barsi, Alpar</creator>
<creator>Dugué, Maël</creator>
<creator>Collinet, Marc</creator>
<creator>Thomé, Jean-Pierre</creator>
<creator>Joaquim-Justo, Célia</creator>
<creator>Roig, Benoit</creator>
<creator>Lagadic, Laurent</creator>
<creator>Ducrot, Virginie</creator>
<contributor>Laboratory of Animal Ecology and Ecotoxicology ; Université de Liège</contributor>
<contributor>Écologie et santé des écosystèmes (ESE) ; Institut national de la recherche agronomique (INRA) - Agrocampus Ouest</contributor>
<contributor>LERES ; Institut de recherche, santé, environnement et travail [Rennes] (Irset) ; INSERM - École Nationale de la Santé Publique - Université de Rennes 1 (UR1) - Université des Antilles et de la Guyane (UAG) - Structure Fédérative de Recherche en Biologie-Santé de Rennes (Biosit) ; Université de Rennes 1 (UR1) - INSERM - CNRS - INSERM - CNRS - INSERM - École Nationale de la Santé Publique - Université de Rennes 1 (UR1) - Université des Antilles et de la Guyane (UAG) - Structure Fédérative de Recherche en Biologie-Santé de Rennes (Biosit) ; Université de Rennes 1 (UR1) - INSERM - CNRS - INSERM - CNRS - École des hautes études en santé publique [Rennes] (EHESP) ; Université européenne de Bretagne (UEB) - PRES Sorbonne Paris Cité - Université européenne de Bretagne (UEB) - PRES Sorbonne Paris Cité</contributor>
<contributor>Belgium funds under a FNRS-F.R.I.A. grant (Fonds pour la Formation à la Recherche dans l'Industrie et dans l'Agriculture); the Belgian FNRS-FRFC grant Number: 2.4.585.10.F; the European Union under the 7th Framework Programme project Mechanistic Effect Model for Ecological Risk Assessment of Chemicals [CREAM], contract number PITN-GA-2009-238148); French funds from the Agency for Food, Environmental and Occupational Health Safety under the "Programme Environnement-Santé-Travail de l'ANSES avec le soutient de l'ITMO cancer dans le cadre du Plan Cancer 2009-2013, contract MODENDO, number EST/2011/1/153.</contributor>
<description>International audience</description>
<source>Environmental Toxicology and Chemistry</source>
<publisher>Society of Environmental Toxicology and Chemistry Press (SETAC)</publisher>
<identifier>hal-00877955</identifier>
<identifier>https://hal.archives-ouvertes.fr/hal-00877955</identifier>
<source>https://hal.archives-ouvertes.fr/hal-00877955</source>
<source>Environmental Toxicology and Chemistry, Society of Environmental Toxicology and Chemistry Press (SETAC), 2013, 32 (7), pp.1552-60. <10.1002/etc.2200></source>
<identifier>DOI : 10.1002/etc.2200</identifier>
<identifier>PUBMED : 23450754</identifier>
<language>en</language>
<subject lang=en>Reproductive toxicity</subject>
<subject lang=en>Endocrine disruptors</subject>
<subject lang=en>Mollusk toxicology</subject>
<subject lang=en>Organotin</subject>
<subject lang=en>Toxicity mechanisms</subject>
<subject>[SDV.MP] Life Sciences/Microbiology and Parasitology</subject>
<subject>[SDV.TOX] Life Sciences/Toxicology</subject>
<type>Journal articles</type>
<description lang=en>Tributyltin (TBT) and triphenyltin (TPT) are emblematic endocrine disruptors, which have been mostly studied in gonochoric prosobranchs. Although both compounds can simultaneously occur in the environment, they have mainly been tested separately for their effects on snail reproduction. Because large discrepancies in experimental conditions occurred in these tests, the present study aimed to compare the relative toxicity of TBT and TPT under similar laboratory conditions in the range of 0 ng Sn/L to 600 ng Sn/L. Tests were performed on the simultaneous hermaphrodite Lymnaea stagnalis, a freshwater snail in which effects of TPT were unknown. Survival, shell length, and reproduction were monitored in a 21-d semistatic test. Frequency of abnormal eggs was assessed as an additional endpoint. Triphenyltin hampered survival while TBT did not. Major effects on shell solidity and reproduction were observed for both compounds, reproductive outputs being more severely hampered by TBT than by TPT. Considering the frequency of abnormal eggs allowed increasing test sensitivity, because snail responses to TBT could be detected at concentrations as low as 19 ng Sn/L. However, the putative mode of action of the 2 compounds could not be deduced from the structure of the molecules or from the response of apical endpoints. Sensitivity of L. stagnalis to TBT and TPT was compared with the sensitivity of prosobranch mollusks with different habitats and different reproductive strategies.</description>
<date>2013-07</date>
</dc>
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