untitled
<OAI-PMH schemaLocation=http://www.openarchives.org/OAI/2.0/ http://www.openarchives.org/OAI/2.0/OAI-PMH.xsd>
<responseDate>2018-01-15T18:33:43Z</responseDate>
<request identifier=oai:HAL:inserm-00866212v1 verb=GetRecord metadataPrefix=oai_dc>http://api.archives-ouvertes.fr/oai/hal/</request>
<GetRecord>
<record>
<header>
<identifier>oai:HAL:inserm-00866212v1</identifier>
<datestamp>2017-12-21</datestamp>
<setSpec>type:ART</setSpec>
<setSpec>subject:sdv</setSpec>
<setSpec>collection:INSERM</setSpec>
<setSpec>collection:UNIV-AG</setSpec>
<setSpec>collection:IFR140</setSpec>
<setSpec>collection:IRSET</setSpec>
<setSpec>collection:UNIV-RENNES1</setSpec>
<setSpec>collection:IRSET-NEED</setSpec>
<setSpec>collection:BIOSIT</setSpec>
<setSpec>openaire</setSpec>
<setSpec>collection:UR1-UFR-SVE</setSpec>
<setSpec>collection:STATS-UR1</setSpec>
<setSpec>collection:UR1-HAL</setSpec>
<setSpec>collection:EHESP</setSpec>
<setSpec>collection:USPC</setSpec>
<setSpec>collection:UR1-SDV</setSpec>
<setSpec>collection:IRSET-6</setSpec>
<setSpec>collection:UNIV-ANGERS</setSpec>
<setSpec>collection:IRSET-EHESP</setSpec>
</header>
<metadata><dc>
<publisher>HAL CCSD</publisher>
<title lang=en>Relationships between radial glial progenitors and 5-HT neurons in the paraventricular organ of adult zebrafish - potential effects of serotonin on adult neurogenesis.</title>
<creator>Pérez, María Rita</creator>
<creator>Pellegrini, Elisabeth</creator>
<creator>Cano-Nicolau, Joel</creator>
<creator>Gueguen, Marie-Madeleine</creator>
<creator>Menouer-Le Guillou, Dounia</creator>
<creator>Merot, Yohann</creator>
<creator>Vaillant, Colette</creator>
<creator>Somoza, Gustavo, </creator>
<creator>Kah, Olivier</creator>
<contributor>Institut de recherche, santé, environnement et travail [Rennes] (Irset) ; Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor>
<contributor>Laboratorio de Ictiofisiología y Acuicultura ; Instituto de Investigaciones Biotecnológicas - Instituto Tecnológico de Chascomús (IIB-INTECH. CONICET-UNSAM)</contributor>
<description>International audience</description>
<source>ISSN: 0953-816X</source>
<source>EISSN: 1460-9568</source>
<source>European Journal of Neuroscience</source>
<publisher>Wiley</publisher>
<identifier>inserm-00866212</identifier>
<identifier>http://www.hal.inserm.fr/inserm-00866212</identifier>
<source>http://www.hal.inserm.fr/inserm-00866212</source>
<source>European Journal of Neuroscience, Wiley, 2013, 38 (9), pp.3292-301. 〈10.1111/ejn.12348〉</source>
<identifier>DOI : 10.1111/ejn.12348</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1111/ejn.12348</relation>
<identifier>PUBMED : 23981075</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/23981075</relation>
<language>en</language>
<subject lang=en>dopamine</subject>
<subject lang=en>fish</subject>
<subject lang=en>hypothalamus</subject>
<subject lang=en>radial glial cell</subject>
<subject lang=en>serotonin</subject>
<subject>[SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>: In non-mammalian vertebrates, serotonin (5-HT)-producing neurons exist in the paraventricular organ (PVO), a diencephalic structure containing cerebrospinal fluid (CSF)-contacting neurons exhibiting 5-HT or dopamine (DA) immunoreactivity. Because the brain of the adult teleost is known for its neurogenic activity supported, for a large part, by radial glial progenitors, this study addresses the origin of newborn 5-HT neurons in the hypothalamus of adult zebrafish. In this species, the PVO exhibits numerous radial glial cells (RGCs) whose somata are located at a certain distance from the ventricle. To study relationships between RGCs and 5-HT CSF-contacting neurons, we performed 5-HT immunohistochemistry in transgenic tg(cyp19a1b-GFP) zebrafish in which RGCs are labelled with GFP under the control of the cyp19a1b promoter. We show that the somata of the 5-HT neurons are located closer to the ventricle than those of RGCs. RGCs extend towards the ventricle cytoplasmic processes that form a continuous barrier along the ventricular surface. In turn, 5-HT neurons contact the CSF via processes that cross this barrier through small pores. Further experiments using proliferating cell nuclear antigen or 5-bromo-2'-deoxyuridine indicate that RGCs proliferate and give birth to 5-HT neurons migrating centripetally instead of centrifugally as in other brain regions. Furthermore, treatment of adult zebrafish with tryptophan hydroxylase inhibitor causes a significant decrease in the number of proliferating cells in the PVO, but not in the mediobasal hypothalamus. These data point to the PVO as an intriguing region in which 5-HT appears to promote genesis of 5-HT neurons that accumulate along the brain ventricles and contact the CSF.</description>
<date>2013-08-25</date>
<contributor>European Project : </contributor>
</dc>
</metadata>
</record>
</GetRecord>
</OAI-PMH>