untitled
<OAI-PMH schemaLocation=http://www.openarchives.org/OAI/2.0/ http://www.openarchives.org/OAI/2.0/OAI-PMH.xsd>
<responseDate>2018-01-15T18:33:40Z</responseDate>
<request identifier=oai:HAL:inserm-00871347v1 verb=GetRecord metadataPrefix=oai_dc>http://api.archives-ouvertes.fr/oai/hal/</request>
<GetRecord>
<record>
<header>
<identifier>oai:HAL:inserm-00871347v1</identifier>
<datestamp>2017-12-22</datestamp>
<setSpec>type:ART</setSpec>
<setSpec>subject:sdv</setSpec>
<setSpec>collection:INSERM</setSpec>
<setSpec>collection:UNIV-AG</setSpec>
<setSpec>collection:IFR140</setSpec>
<setSpec>collection:UNIV-RENNES1</setSpec>
<setSpec>collection:IRSET</setSpec>
<setSpec>collection:UNIV-BREST</setSpec>
<setSpec>collection:IRSET-SMS</setSpec>
<setSpec>collection:BIOSIT</setSpec>
<setSpec>collection:M2S</setSpec>
<setSpec>collection:UR2-HB</setSpec>
<setSpec>collection:UR1-UFR-SVE</setSpec>
<setSpec>collection:ENS-CACHAN</setSpec>
<setSpec>collection:UR1-HAL</setSpec>
<setSpec>collection:STATS-UR1</setSpec>
<setSpec>collection:EHESP</setSpec>
<setSpec>collection:USPC</setSpec>
<setSpec>collection:UR1-SDV</setSpec>
<setSpec>collection:UR1-SHS</setSpec>
<setSpec>collection:IRSET-2</setSpec>
<setSpec>collection:UNIV-ANGERS</setSpec>
<setSpec>collection:UNIV-RENNES2</setSpec>
</header>
<metadata><dc>
<publisher>HAL CCSD</publisher>
<title lang=en>Sphingolipids and response to chemotherapy.</title>
<creator>Dimanche-Boitrel, Marie-Thérèse</creator>
<creator>Rébillard, Amélie</creator>
<contributor>Stress, membrane, signalisation ; Institut de recherche, santé, environnement et travail [Rennes] (Irset) ; Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ) - Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor>
<contributor>Laboratoire Mouvement Sport Santé (M2S) ; École normale supérieure - Cachan (ENS Cachan) - Université de Rennes 1 (UR1) - Université de Brest (UBO) - Université de Rennes 2 (UR2) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor>
<description>International audience</description>
<source>Handb Exp Pharmacol</source>
<source>Sphingolipids in Disease</source>
<publisher>Vsevolod Gurevich</publisher>
<identifier>inserm-00871347</identifier>
<identifier>http://www.hal.inserm.fr/inserm-00871347</identifier>
<source>http://www.hal.inserm.fr/inserm-00871347</source>
<source>Handb Exp Pharmacol, Vsevolod Gurevich, 2013, 216, pp.73-91. 〈10.1007/978-3-7091-1511-4_4〉</source>
<identifier>PUBMED : 23563652</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/23563652</relation>
<identifier>DOI : 10.1007/978-3-7091-1511-4_4</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1007/978-3-7091-1511-4_4</relation>
<language>en</language>
<subject lang=en>chemotherapy</subject>
<subject lang=en>ceramide</subject>
<subject lang=en>sphingomyelinases</subject>
<subject lang=en>ceramide kinase</subject>
<subject lang=en>sphingosine kinase</subject>
<subject>[SDV.CAN] Life Sciences [q-bio]/Cancer</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>Chemotherapy is frequently used to treat primary or metastatic cancers, but intrinsic or acquired drug resistance limits its efficiency. Sphingolipids are important regulators of various cellular processes including proliferation, apoptosis, differentiation, angiogenesis, stress, and inflammatory responses which are linked to various aspects of cancer, like tumor growth, neoangiogenesis, and response to chemotherapy. Ceramide, the central molecule of sphingolipid metabolism, generally mediates antiproliferative and proapoptotic functions, whereas sphingosine-1-phosphate and other derivatives have opposing effects. Among the variety of enzymes that control ceramide generation, acid or neutral sphingomyelinases and ceramide synthases are important targets to allow killing of cancer cells by chemotherapeutic drugs. On the contrary, glucosylceramide synthase, ceramidase, and sphingosine kinase are other targets driving cancer cell resistance to chemotherapy. This chapter focuses on ceramide-based mechanisms leading to cancer therapy sensitization or resistance which could have some impacts on the development of novel cancer therapeutic strategies.</description>
<date>2013</date>
</dc>
</metadata>
</record>
</GetRecord>
</OAI-PMH>
