untitled
<OAI-PMH schemaLocation=http://www.openarchives.org/OAI/2.0/ http://www.openarchives.org/OAI/2.0/OAI-PMH.xsd>
<responseDate>2018-01-15T18:32:43Z</responseDate>
<request identifier=oai:HAL:hal-00877439v1 verb=GetRecord metadataPrefix=oai_dc>http://api.archives-ouvertes.fr/oai/hal/</request>
<GetRecord>
<record>
<header>
<identifier>oai:HAL:hal-00877439v1</identifier>
<datestamp>2017-12-21</datestamp>
<setSpec>type:ART</setSpec>
<setSpec>subject:sdv</setSpec>
<setSpec>collection:UNIV-AG</setSpec>
<setSpec>collection:IFR140</setSpec>
<setSpec>collection:UNIV-RENNES1</setSpec>
<setSpec>collection:IRSET</setSpec>
<setSpec>collection:IRSET-TNGC</setSpec>
<setSpec>collection:BIOSIT</setSpec>
<setSpec>collection:UR1-UFR-SVE</setSpec>
<setSpec>collection:STATS-UR1</setSpec>
<setSpec>collection:UR1-HAL</setSpec>
<setSpec>collection:EHESP</setSpec>
<setSpec>collection:USPC</setSpec>
<setSpec>collection:UR1-SDV</setSpec>
<setSpec>collection:IRSET-7</setSpec>
<setSpec>collection:UNIV-ANGERS</setSpec>
</header>
<metadata><dc>
<publisher>HAL CCSD</publisher>
<title lang=en>Transcription of two long noncoding RNAs mediates mating-type control of gametogenesis in budding yeast.</title>
<creator>Van Werven, Folkert J</creator>
<creator>Neuert, Gregor</creator>
<creator>Hendrick, Natalie</creator>
<creator>Lardenois, Aurélie</creator>
<creator>Buratowski, Stephen</creator>
<creator>Van Oudenaarden, Alexander</creator>
<creator>Primig, Michael</creator>
<creator>Amon, Angelika</creator>
<contributor>Transcriptional networks in gametogenesis and cancer ; Institut de recherche, santé, environnement et travail [Rennes] (Irset) ; Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ) - Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor>
<contributor>grant GM62207 to A.A.; Rubicon-grant (825.09.004) from the Netherlands Organization for Scientific Research to F.W.; grants from the National Science Foundation (ECCS-0835623); NIH/NCI Physical Sciences Oncology Center at MIT (U54CA143874) to A.v.O. and G.N.; grants Inserm Avenir (R07216NS); CREATE (NR11016NN) to M. P. A.A. ; Investigator of the Howard Hughes Medical Institute</contributor>
<description>International audience</description>
<source>ISSN: 0092-8674</source>
<source>EISSN: 1097-4172</source>
<source>Cell</source>
<publisher>Elsevier</publisher>
<identifier>hal-00877439</identifier>
<identifier>https://hal.archives-ouvertes.fr/hal-00877439</identifier>
<source>https://hal.archives-ouvertes.fr/hal-00877439</source>
<source>Cell, Elsevier, 2012, 150 (6), pp.1170-81. 〈10.1016/j.cell.2012.06.049〉</source>
<identifier>DOI : 10.1016/j.cell.2012.06.049</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1016/j.cell.2012.06.049</relation>
<identifier>PUBMED : 22959267</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/22959267</relation>
<language>en</language>
<subject>[SDV.BC] Life Sciences [q-bio]/Cellular Biology</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>The cell-fate decision leading to gametogenesis is essential for sexual reproduction. In S. cerevisiae, only diploid MATa/α but not haploid MATa or MATα cells undergo gametogenesis, known as sporulation. We find that transcription of two long noncoding RNAs (lncRNAs) mediates mating-type control of sporulation. In MATa or MATα haploids, expression of IME1, the central inducer of gametogenesis, is inhibited in cis by transcription of the lncRNA IRT1, located in the IME1 promoter. IRT1 transcription recruits the Set2 histone methyltransferase and the Set3 histone deacetylase complex to establish repressive chromatin at the IME1 promoter. Inhibiting expression of IRT1 and an antisense transcript that antagonizes the expression of the meiotic regulator IME4 allows cells expressing the haploid mating type to sporulate with kinetics that are indistinguishable from that of MATa/α diploids. Conversely, expression of the two lncRNAs abolishes sporulation in MATa/α diploids. Thus, transcription of two lncRNAs governs mating-type control of gametogenesis in yeast.</description>
<date>2012-09-14</date>
</dc>
</metadata>
</record>
</GetRecord>
</OAI-PMH>
