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<title lang=en>Targeting the ceramide system in cancer.</title>
<creator>Henry, Brian</creator>
<creator>Möller, Christina</creator>
<creator>Dimanche-Boitrel, Marie-Therese</creator>
<creator>Gulbins, Erich</creator>
<creator>Becker, Katrin Anne</creator>
<contributor>Department of Molecular Biology ; University of Duisburg-Essen [Essen]</contributor>
<contributor>Stress, membrane, signalisation ; Institut de recherche, santé, environnement et travail [Rennes] (Irset) ; Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ) - Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor>
<description>International audience</description>
<source>ISSN: 0304-3835</source>
<source>Cancer Letters</source>
<publisher>Elsevier</publisher>
<identifier>hal-00682458</identifier>
<identifier>https://hal.archives-ouvertes.fr/hal-00682458</identifier>
<source>https://hal.archives-ouvertes.fr/hal-00682458</source>
<source>Cancer Letters, Elsevier, 2013, 332 (2), pp.286-294. 〈10.1016/j.canlet.2011.07.010〉</source>
<identifier>DOI : 10.1016/j.canlet.2011.07.010</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1016/j.canlet.2011.07.010</relation>
<identifier>PUBMED : 21862212</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/21862212</relation>
<language>en</language>
<subject lang=en>Ceramide</subject>
<subject lang=en>Sphingomyelinases</subject>
<subject lang=en>Cell death</subject>
<subject lang=en>Cancer</subject>
<subject>[SDV.CAN] Life Sciences [q-bio]/Cancer</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>Sphingolipids, in particular ceramide, have been described as important components of cellular signalling pathways. Ceramide can be produced via multiple mechanisms including through the hydrolysis of sphingomyelin by acid and neutral sphingomyelinase or by a de novo synthesis pathway. Recent studies have identified sphingomyelinases and ceramide synthases as important targets for γ-irradiation and chemotherapeutic drugs. Likewise, common cancer treatment modalities, such as γ-irradiation and many chemotherapeutic agents, induce cell death via the generation of ceramide. This suggests that the manipulation of ceramide production and metabolism could offer promising a means for the enhancement of anti-tumor therapies. The focus of this mini-review will be to discuss contemporary evidence suggesting that ceramide forming pathways and ceramide itself are important targets for the treatment of tumors and the development of novel tumor treatment strategies.</description>
<date>2013-05-28</date>
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