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<identifier>oai:HAL:hal-01427889v1</identifier>
<datestamp>2017-12-21</datestamp>
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<publisher>HAL CCSD</publisher>
<title lang=en>Vitamin D Status, Insulin Resistance, Leptin-To-Adiponectin Ratio in Adolescents: Results of a 1-Year Lifestyle Intervention</title>
<creator>Rambhojan, Christine</creator>
<creator>Larifla, Laurent</creator>
<creator>Clepier, Josiane</creator>
<creator>Bouaziz-Amar, Elodie</creator>
<creator>Velayoudom Cephise, Fritz-Line</creator>
<creator>Blanchet-Deverly, Anne</creator>
<creator>Armand, Christophe</creator>
<creator>Plumasseau, Jean</creator>
<creator>Lacorte, Jean-Marc</creator>
<creator>Foucan, Lydia</creator>
<contributor>Equipe de recherche sur le Risque Cardio métabolique ; Université des Antilles et de la Guyane (UAG)</contributor>
<contributor>Réseau GRANDIR</contributor>
<contributor>Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Institute of cardiometabolism and nutrition (ICAN) ; Université Pierre et Marie Curie - Paris 6 (UPMC) - Assistance publique - Hôpitaux de Paris (AP-HP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - CHU Pitié-Salpêtrière [APHP]</contributor>
<contributor>Centre d’Examens de Santé, AGREXAM, Guadeloupe</contributor>
<description>International audience</description>
<source>Open Access Macedonian Journal of Medical Sciences</source>
<identifier>hal-01427889</identifier>
<identifier>http://hal.upmc.fr/hal-01427889</identifier>
<source>http://hal.upmc.fr/hal-01427889</source>
<source>Open Access Macedonian Journal of Medical Sciences, 2016, 4 (4), pp.596-602</source>
<identifier>PUBMEDCENTRAL : PMC5175505</identifier>
<language>en</language>
<subject lang=en>Vitamin D deficiency</subject>
<subject lang=en>Insulin resistance</subject>
<subject lang=en>Leptin-to-adiponectin ratio</subject>
<subject lang=en>Adolescents</subject>
<subject lang=en>Lifestyle intervention</subject>
<subject>[SDV.MHEP] Life Sciences [q-bio]/Human health and pathology</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>AIM:We aimed to study the relationships between circulating 25-hydroxyvitamin D [25(OH)D], insulin resistance and leptin-to-adiponectin (L/A) ratio in Guadeloupean children and adolescents and to analyse the changes in 25(OH)D levels after a 1-year lifestyle intervention program.METHODS:25(OH)D concentrations were measured via a chemiluminescence assay. Cardiometabolic risk factors, homoeostasis model assessment of insulin resistance (HOMA-IR), and adipokines were measured. The lifestyle intervention included dietary counselling, regular physical activity.RESULTS:Among 117 girls and boys (11–15 years old, 31.6% obese), 40% had vitamin D deficiency (25(OH)D levels < 20 ng/mL). With linear regression models where 25(OH)D and HOMA-IR acted as independent variables and age, sex, BMI, L/A ratio as covariates, 25(OH)D was significantly associated with HOMA-IR alone (P = 0.036). HOMA-IR was also associated with BMI z-score ≥ 2, L/A ratio and an interaction term BMI z-score ≥ 2*L/A ratio (P < 0.001 for all). After one year, in 78 children/adolescent, mean serum 25(OH)D increased significantly from 21.4 ± 4.9 ng/mL at baseline to 23.2 ± 6.0 after 1 year; P = 0.003 whereas BMI z-score, HOMA-IR and L/A ratio decreased significantly (P = 0.003, P < 0.001 and P = 0.012; respectively).CONCLUSION:The association between 25(OH)D and HOMA-IR, independently of obesity and the high prevalence of vitamin D deficiency should be considered in order to prevent the later incidence of T2DM. A healthy lifestyle including non-sedentary and outdoor activities could be a way for improving vitamin D status.</description>
<date>2016-12-15</date>
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