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<title lang=en>0280 Occupational risk factors for prostate cancer: a case-control study in Guadeloupe (French West Indies).</title>
<creator>Morvan, Karène</creator>
<creator>Multigner, Luc</creator>
<creator>Blanchet, Pascal</creator>
<creator>Luce, Danièle</creator>
<contributor>Institut de recherche, santé, environnement et travail [Rennes] (Irset) ; Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor>
<description>International audience</description>
<source>Challenges for Occupational Epidemiology in the 21st Century EPICOH 2014</source>
<coverage>Chicago, United States</coverage>
<identifier>hal-01118558</identifier>
<identifier>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01118558</identifier>
<source>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01118558</source>
<source>Challenges for Occupational Epidemiology in the 21st Century EPICOH 2014, Jun 2014, Chicago, United States. Occup Environ Med, 71 Suppl 1 (Suppl_1), pp.A100, 2014, 〈10.1136/oemed-2014-102362.312〉</source>
<identifier>DOI : 10.1136/oemed-2014-102362.312</identifier>
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<identifier>PUBMED : 25018167</identifier>
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<subject>[SDV] Life Sciences [q-bio]</subject>
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<description lang=en>To study the associations between occupation, industry and prostate cancer risk in Guadeloupe, a high incidence area. Incident cases of prostate cancer (707 cases) and 722 population controls were included. Information on lifetime occupational history and other potential risk factors was collected by interview. Logistic regression was used to estimate adjusted odds-ratios (OR) and their 95% confidence intervals (CI). A significantly decreased risk was observed in farmers (OR=0.5; CI 0.4-0.7), whereas marginally elevated ORs were found for farm workers, especially in sugarcane and banana farming. Banana plantation workers had been exposed to chlordecone, an estrogenic insecticide previously found to be associated with prostate cancer risk in this population. Significantly increased risks of prostate cancer were found in stock clerks (OR=2.7; CI 1.0-7.2), fishermen (OR=2.0; CI 1.0-4.0), mail distribution clerks (OR=7.7; CI 1.7-34.4) and electricians employed for more than 20 years (OR=4.0; CI 1.0-15.8), as well as in public administration (OR=1.8; CI 1.2-2.9), retail trade (OR=2.6; CI 1.1-6.0) and manufacture of food products (OR=2.0; CI 1.1-3.9), particularly sugar (OR=13.2; IC 1.6-108). Non-significantly elevated ORs were also seen for construction workers and transport equipment operators. Although the overall findings suggest that occupational factors have only a limited role in prostate cancer aetiology, elevated risks of prostate cancer were found in several occupations or industries. Exposure to pesticides, solvents, traffic-related air pollution, low physical activity, whole-body vibration may explain some of these increased risks.</description>
<date>2014-06-24</date>
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