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<title lang=en>5-hydroxymethylcytosine marks postmitotic neural cells in the adult and developing vertebrate central nervous system</title>
<creator>Diotel, Nicolas</creator>
<creator>Mérot, Yohann</creator>
<creator>Coumailleau, Pascal</creator>
<creator>Gueguen, Marie-Madeleine</creator>
<creator>Sérandour, Aurélien A.</creator>
<creator>Salbert, Gilles</creator>
<creator>Kah, Olivier</creator>
<contributor>Diabète athérothrombose et thérapies Réunion Océan Indien (DéTROI) ; Université de la Réunion (UR) - Institut National de la Santé et de la Recherche Médicale (INSERM)</contributor>
<contributor>Institut de recherche, santé, environnement et travail [Rennes] (Irset) ; Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor>
<contributor>Institut de Génétique et Développement de Rennes (IGDR) ; Université de Rennes 1 (UR1) - Centre National de la Recherche Scientifique (CNRS) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor>
<description>International audience</description>
<source>Journal of Comparative Neurology</source>
<identifier>hal-01439354</identifier>
<identifier>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01439354</identifier>
<source>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01439354</source>
<source>Journal of Comparative Neurology, 2017, 525 (3), pp.478-497. 〈10.1002/cne.24077〉</source>
<identifier>DOI : 10.1002/cne.24077</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1002/cne.24077</relation>
<identifier>PUBMED : 27414756</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/27414756</relation>
<language>en</language>
<subject>[SDV.GEN] Life Sciences [q-bio]/Genetics</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>The epigenetic mark 5-hydroxymethylcytosine (5hmC) is a cytosine modification that is abundant in the central nervous system of mammals and which results from 5-methylcytosine oxidation by TET enzymes. Such a mark is suggested to play key roles in the regulation of chromatin structure and gene expression. However, its precise functions still remain poorly understood and information about its distribution in non-mammalian species is still lacking. Here, the distribution of 5hmC was investigated in the brain of adult zebrafish, African claw frog, and mouse in a comparative manner. We show that zebrafish neurons are endowed with high levels of 5hmC, whereas quiescent or proliferative neural progenitors show low to undetectable levels of the modified cytosine. In the brain of larval and juvenile Xenopus, 5hmC is also detected in neurons, while ventricular proliferative cells do not display this epigenetic mark. Similarly, 5hmC is enriched in neurons compared to neural progenitors of the ventricular zone in the mouse developing cortex. Interestingly, 5hmC colocalized with the methylated DNA binding protein MeCP2 and with the active chromatin histone modification H3K4me2 in mouse neurons. Taken together, our results show an evolutionarily conserved cerebral distribution of 5hmC between fish and tetrapods and reinforce the idea that 5hmC fulfills major functions in the control of chromatin activity in vertebrate neurons. J. Comp. Neurol. 525:478-497, 2017. © 2016 Wiley Periodicals, Inc.</description>
<date>2017</date>
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