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<identifier>oai:HAL:hal-01668321v1</identifier>
<datestamp>2018-01-10</datestamp>
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<publisher>HAL CCSD</publisher>
<title lang=en>Cerebral and muscle microvascular oxygenation in children with sickle cell disease: Influence of hematology, hemorheology and vasomotion.</title>
<creator>Charlot, Keyne</creator>
<creator>Antoine-Jonville, Sophie</creator>
<creator>Moeckesch, Berenike</creator>
<creator>Jumet, Stéphane</creator>
<creator>Romana, Marc</creator>
<creator>Waltz, Xaxier</creator>
<creator>Divialle-Doumdo, Lydia</creator>
<creator>Hardy-Dessources, Marie-Dominique</creator>
<creator>Petras, Marie</creator>
<creator>Tressieres, Benoit</creator>
<creator>Tarer, Vanessa</creator>
<creator>Hue, Olivier</creator>
<creator>Etienne-Julan, Maryse</creator>
<creator>Connes, Philippe</creator>
<contributor>Biologie intégrée du globule rouge ; Université des Antilles et de la Guyane (UAG) - Institut National de la Transfusion Sanguine [Paris] (INTS) - Université Paris Diderot - Paris 7 (UPD7) - Institut National de la Santé et de la Recherche Médicale (INSERM)</contributor>
<contributor>Adaptations au Climat Tropical, Exercice et Santé (ACTES) ; Université des Antilles et de la Guyane (UAG)</contributor>
<contributor>Biologie Intégrée du Globule Rouge ; Institut National de la Transfusion Sanguine [Paris] (INTS) - Université Paris Diderot - Paris 7 (UPD7) - Université de la Réunion (UR) - Institut National de la Santé et de la Recherche Médicale (INSERM) - CHU de Pointe-à-Pitre</contributor>
<contributor>Université des Antilles et de la Guyane (UAG)</contributor>
<contributor>Unité Transversale de la Drépanocytose ; CHU de Pointe-à-Pitre/Abymes</contributor>
<contributor>Centre d'investigation clinique Antilles-Guyane ; Institut National de la Santé et de la Recherche Médicale (INSERM) - CH Cayenne</contributor>
<contributor>Service d'Orthopédie et de Traumatologie ; Université des Antilles et de la Guyane (UAG) - CHU Pointe-à-Pitre/Abymes</contributor>
<contributor>Unité Transversale de la Drépanocytose ; CHU Pointe-à-Pitre/Abymes</contributor>
<contributor>Institut Universitaire de France (IUF) ; Ministère de l'Éducation nationale, de l’Enseignement supérieur et de la Recherche (M.E.N.E.S.R.)</contributor>
<description>International audience</description>
<source>ISSN: 1079-9796</source>
<source>EISSN: 1096-0961</source>
<source>Blood Cells, Molecules and Diseases</source>
<publisher>Elsevier</publisher>
<identifier>hal-01668321</identifier>
<identifier>https://hal.univ-antilles.fr/hal-01668321</identifier>
<source>https://hal.univ-antilles.fr/hal-01668321</source>
<source>Blood Cells, Molecules and Diseases, Elsevier, 2017, 〈10.1016/j.bcmd.2017.03.015〉</source>
<identifier>DOI : 10.1016/j.bcmd.2017.03.015</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1016/j.bcmd.2017.03.015</relation>
<language>en</language>
<subject lang=en>Near-infrared spectroscopy</subject>
<subject lang=en> Sickle cell disease</subject>
<subject lang=en> Tissue oxygen index</subject>
<subject lang=en> Vasomotion</subject>
<subject>[SDV.MHEP.HEM] Life Sciences [q-bio]/Human health and pathology/Hematology</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>The present study investigated cerebral and muscle hemoglobin oxygen saturation (tissue oxygen index, TOI) in children with sickle cell anemia (SS), sickle cell hemoglobin C disease (SC) and healthy children (AA). TOI was measured by near-infrared spectroscopy (NIRS) and spectral analysis of the TOI variability was used to assess flowmotion and vasomotion. Arterial oxyhemoglobin saturation (SpO2), hemorheological and hematological parameters were also measured in SS and SC children. Both TOI were lower in SS compared to both AA and SC children, with SC exhibiting lower values than AA children. Cerebral vasomotion expressed in absolute values was enhanced in SS compared to AA and SC children. Muscle vasomotion did not differ between the three groups. Hematocrit, SpO2 and red blood cell deformability were positively associated with cerebral TOI in SS children. We demonstrated that 1) cerebral and muscle TOI were markedly decreased in SS children while the decrease of TOI was milder in SC children, 2) cerebral TOI level was associated with several biological markers in SS children only and 3) cerebral vasomotion was enhanced in SS, possibly to counterbalance the effects of chronic cerebral hypoxia.</description>
<date>2017</date>
</dc>
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