untitled
<OAI-PMH schemaLocation=http://www.openarchives.org/OAI/2.0/ http://www.openarchives.org/OAI/2.0/OAI-PMH.xsd>
<responseDate>2018-01-15T18:40:49Z</responseDate>
<request identifier=oai:HAL:hal-00682466v1 verb=GetRecord metadataPrefix=oai_dc>http://api.archives-ouvertes.fr/oai/hal/</request>
<GetRecord>
<record>
<header>
<identifier>oai:HAL:hal-00682466v1</identifier>
<datestamp>2018-01-11</datestamp>
<setSpec>type:ART</setSpec>
<setSpec>subject:sdv</setSpec>
<setSpec>collection:CNRS</setSpec>
<setSpec>collection:IFR140</setSpec>
<setSpec>collection:IRSET</setSpec>
<setSpec>collection:UNIV-RENNES1</setSpec>
<setSpec>collection:UNIV-AG</setSpec>
<setSpec>collection:BIOSIT</setSpec>
<setSpec>collection:UR1-UFR-SVE</setSpec>
<setSpec>collection:UR1-SDV</setSpec>
<setSpec>collection:UR1-HAL</setSpec>
<setSpec>collection:EHESP</setSpec>
<setSpec>collection:STATS-UR1</setSpec>
<setSpec>collection:USPC</setSpec>
<setSpec>collection:UNIV-ANGERS</setSpec>
</header>
<metadata><dc>
<publisher>HAL CCSD</publisher>
<title lang=en>CD95-mediated cell signaling in cancer: mutations and post-translational modulations.</title>
<creator>Tauzin, Sébastien</creator>
<creator>Debure, Laure</creator>
<creator>Moreau, Jean-François</creator>
<creator>Legembre, Patrick</creator>
<contributor>Récepteur de mort et échappement tumoral ; Institut de recherche, santé, environnement et travail [Rennes] (Irset) ; Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ) - Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor>
<contributor>Composantes innées de la réponse immunitaire et différenciation (CIRID) ; Université Bordeaux Segalen - Bordeaux 2 - Centre National de la Recherche Scientifique (CNRS)</contributor>
<contributor>INCa; Région Bretagne; Rennes Métropole; Ligue Contre le Cancer (Comités d'Ille-et-Vilaine, Comité du Morbihan, Comité de la Dordogne, Comités des Pyrénées-Atlantiques)</contributor>
<description>International audience</description>
<source>ISSN: 1420-682X</source>
<source>EISSN: 1420-9071</source>
<source>Cellular and Molecular Life Sciences</source>
<publisher>Springer Verlag (Germany)</publisher>
<publisher>Springer Verlag</publisher>
<identifier>hal-00682466</identifier>
<identifier>https://hal.archives-ouvertes.fr/hal-00682466</identifier>
<source>https://hal.archives-ouvertes.fr/hal-00682466</source>
<source>Cellular and Molecular Life Sciences, Springer Verlag, 2011, 69 (8), pp.1261-1277. 〈10.1007/s00018-011-0866-4〉</source>
<identifier>DOI : 10.1007/s00018-011-0866-4</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1007/s00018-011-0866-4</relation>
<identifier>PUBMED : 22042271</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/22042271</relation>
<language>en</language>
<subject lang=en>Fas</subject>
<subject lang=en>Oncogene</subject>
<subject lang=en>Tumor suppressor</subject>
<subject lang=en>Lipid rafts</subject>
<subject lang=en>ALPS</subject>
<subject>[SDV.CAN] Life Sciences [q-bio]/Cancer</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>Apoptosis has emerged as a fundamental process important in tissue homeostasis, immune response, and during development. CD95 (also known as Fas), a member of the tumor necrosis factor receptor (TNF-R) superfamily, has been initially cloned as a death receptor. Its cognate ligand, CD95L, is mainly found at the plasma membrane of activated T-lymphocytes and natural killer cells where it contributes to the elimination of transformed and infected cells. According to its implication in the immune homeostasis and immune surveillance, and since several malignant cells of various histological origins exhibit loss-of-function mutations, which cause resistance towards the CD95-mediated apoptotic signal, CD95 has been classified as a tumor suppressor gene. Nevertheless, this assumption has been recently challenged, as in certain pathophysiological contexts, CD95 engagement transmits non-apoptotic signals that promote inflammation, carcinogenesis or liver/peripheral nerve regeneration. The focus of this review is to discuss these apparent contradictions of the known function(s) of CD95.</description>
<date>2011-11-01</date>
</dc>
</metadata>
</record>
</GetRecord>
</OAI-PMH>
