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<title lang=en>Cold/menthol TRPM8 receptors initiate the cold-shock response and protect germ cells from cold-shock-induced oxidation</title>
<creator>Borowiec, Anne-Sophie</creator>
<creator>Sion, Benoit</creator>
<creator>Chalmel, Frédéric</creator>
<creator>Rolland, Antoine D.</creator>
<creator>Lemonnier, Loic</creator>
<creator>De Clerck, Tatiana</creator>
<creator>Bokhobza, Alexandre</creator>
<creator>Derouiche, Sandra</creator>
<creator>Dewailly, Etienne</creator>
<creator>Slomianny, Christian</creator>
<creator>Mauduit, Claire</creator>
<creator>Benahmed, Mohamed</creator>
<creator>Roudbaraki, Morad</creator>
<creator>Jégou, Bernard</creator>
<creator>Prevarskaya, Natalia</creator>
<creator>Bidaux, Gabriel</creator>
<contributor>Neuro-Dol (Neuro-Dol) ; Université d'Auvergne - Clermont-Ferrand I (UdA) - Institut National de la Santé et de la Recherche Médicale (INSERM)</contributor>
<contributor>Institut de recherche, santé, environnement et travail [Rennes] (Irset) ; Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor>
<contributor>Rôle des canaux ioniques membranaires et du calcium intracellulaire dans la physiopathologie de la prostate ; Université de Lille, Sciences et Technologies - Institut National de la Santé et de la Recherche Médicale (INSERM)</contributor>
<contributor>Centre d'infection et d'immunité de Lille (CIL) ; Université de Lille, Sciences et Technologies - Institut Pasteur de Lille - Institut National de la Santé et de la Recherche Médicale (INSERM) - IFR142 - Université de Lille, Droit et Santé - Centre National de la Recherche Scientifique (CNRS)</contributor>
<contributor>Rôle des canaux ioniques membranaires et du calcium intracellulaire dans la psysiopathologie de la prostate ; Institut National de la Santé et de la Recherche Médicale (INSERM)</contributor>
<contributor>Laboratoire de physiologie cellulaire, (U1003) ; Université Lille Nord de France - Institut National de la Santé et de la Recherche Médicale (INSERM)</contributor>
<contributor>Centre méditérannéen de médecine moléculaire (C3M) ; Institut National de la Santé et de la Recherche Médicale (INSERM) - Université Nice Sophia Antipolis (UNS) ; Université Côte d'Azur (UCA) - Université Côte d'Azur (UCA)</contributor>
<contributor>Laboratory of Excellence, Ion Channels Science and Therapeutics ; Université de Lille, Sciences et Technologies</contributor>
<contributor>Institut de Recherche Interdisciplinaire [Villeneuve d'Ascq] (IRI) ; Université de Lille, Sciences et Technologies - Université de Lille, Droit et Santé - Centre National de la Recherche Scientifique (CNRS)</contributor>
<contributor>Genoway team and Charles River Laboratories (Lyon, France)</contributor>
<contributor> INSERM</contributor>
<contributor> Ministere de l'Education Nationale</contributor>
<contributor> Ligue Nationale Contre le Cancer</contributor>
<contributor> Region Nord-Pas-de-Calais</contributor>
<contributor> ANR [TRPM8/REPROD]</contributor>
<contributor> Fondation pour la recherche medicale</contributor>
<description>International audience</description>
<source>ISSN: 0892-6638</source>
<source>EISSN: 1530-6860</source>
<source>FASEB Journal</source>
<publisher>Federation of American Society of Experimental Biology</publisher>
<identifier>hal-01390973</identifier>
<identifier>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01390973</identifier>
<source>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01390973</source>
<source>FASEB Journal, Federation of American Society of Experimental Biology, 2016, 30 (9), pp.3155--3170. 〈10.1096/fj.201600257R〉</source>
<identifier>DOI : 10.1096/fj.201600257R</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1096/fj.201600257R</relation>
<identifier>PUBMED : 27317670</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/27317670</relation>
<language>en</language>
<subject lang=en>hydroperoxide glutathione-peroxidase</subject>
<subject lang=en> biological significance</subject>
<subject lang=en> regulatory mechanism</subject>
<subject lang=en> spermatogenic cells</subject>
<subject lang=en> epithelial-cells</subject>
<subject lang=en> dna-damage</subject>
<subject lang=en> rat testis</subject>
<subject lang=en> apoptosis</subject>
<subject lang=en> stress</subject>
<subject lang=en> expression</subject>
<subject>[SDV.EE.SANT] Life Sciences [q-bio]/Ecology, environment/Health</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>Testes of most male mammals present the particularity of being externalized from the body and are consequently slightly cooler than core body temperature (4-8 degrees C below). Although, hypothermia of the testis is known to increase germ cells apoptosis, little is known about the underlying molecular mechanisms, including cold sensors, transduction pathways, and apoptosis triggers. In this study, using a functional knockout mouse model of the cold and menthol receptors, dubbed transient receptor potential melastatine 8 (TRPM8) channels, we found that TRPM8 initiated the cold-shock response by differentially modulating cold- and heat-shock proteins. Besides, apoptosis of germ cells increased in proportion to the cooling level in control mice but was independent of temperature in knockout mice. We also observed that the rate of germ cell death correlated positively with the reactive oxygen species level and negatively with the expression of the detoxifying enzymes. This result suggests that the TRPM8 sensor is a key determinant of germ cell fate under hypothermic stimulation.Borowiec, A.-S., Sion, B., Chalmel, F., Rolland, A. D., Lemonnier, L., De Clerck, T., Bokhobza, A., Derouiche, S., Dewailly, E., Slomianny, C., Mauduit, C., Benahmed, M., Roudbaraki, M., Jegou, B., Prevarskaya, N., Bidaux, G. Cold/menthol TRPM8 receptors initiate the cold-shock response and protect germ cells from cold-shock-induced oxidation.</description>
<date>2016</date>
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