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<identifier>oai:HAL:inserm-01476019v1</identifier>
<datestamp>2017-12-21</datestamp>
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<publisher>HAL CCSD</publisher>
<title lang=en>Chikungunya Infection in Hospitalized Febrile Infants Younger Than 3 Months of Age.</title>
<creator>Elenga, Narcisse</creator>
<creator>Folin, Marion</creator>
<creator>Vandamme, Yves-Marie</creator>
<creator>Cuadro-Alvarez, Emma</creator>
<creator>Long, Laurence</creator>
<creator>Njuieyon, Falucar</creator>
<creator>Martin, Elise</creator>
<creator>Kom-Tchameni, Rémi</creator>
<creator>Defo, Antoine</creator>
<creator>Razafindrakoto, Sitraka Herinantenaina</creator>
<creator>Mrsic, Yajaira</creator>
<creator>Couppie, Pierre</creator>
<creator>Nacher, Mathieu</creator>
<creator>Dufour, Julie</creator>
<contributor>Service de Pédiatrie [Cayenne, Guyanne Française] ; Centre Hospitalier de Cayenne Andrée Rosemon</contributor>
<contributor>Centre Hospitalier Universitaire d'Angers (CHU Angers) ; PRES Université Nantes Angers Le Mans [UNAM]</contributor>
<contributor>Centre d'Investigation Clinique Antilles-Guyane (CIC - Antilles Guyane) ; Université des Antilles et de la Guyane (UAG) - Institut National de la Santé et de la Recherche Médicale (INSERM) - CHU de Pointe-à-Pitre - Centre Hospitalier de Cayenne Andrée Rosemon - CHU de Fort de France</contributor>
<contributor>Service de Dermatologie [Cayenne, Guyanne Française] ; Centre Hospitalier Andre Rosemon</contributor>
<description>International audience</description>
<source>ISSN: 0891-3668</source>
<source>Pediatric Infectious Disease Journal</source>
<publisher>Lippincott, Williams & Wilkins</publisher>
<identifier>inserm-01476019</identifier>
<identifier>http://www.hal.inserm.fr/inserm-01476019</identifier>
<identifier>http://www.hal.inserm.fr/inserm-01476019/document</identifier>
<identifier>http://www.hal.inserm.fr/inserm-01476019/file/2017%2C%20Elenga%20-%20Chikungunya%20Infection%20in%20hospitalized%20febrile%20infants.pdf</identifier>
<source>http://www.hal.inserm.fr/inserm-01476019</source>
<source>Pediatric Infectious Disease Journal, Lippincott, Williams & Wilkins, 2017, Epub ahead of print. 〈10.1097/INF.0000000000001541〉</source>
<identifier>DOI : 10.1097/INF.0000000000001541</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1097/INF.0000000000001541</relation>
<identifier>PUBMED : 28060043</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/28060043</relation>
<language>en</language>
<subject lang=en>Chikungunya virus</subject>
<subject lang=en>clinical triad fever-irritability-elevated procalcitonin</subject>
<subject lang=en>Infants</subject>
<subject lang=en>French Guiana</subject>
<subject>[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=0>BACKGROUND:Fever in infants younger than 3 months is generally a cause for concern because of the risk for a serious bacterial infection. The aim of this study was to describe clinical and biological features of Chikungunya infection in infants < 3 months of age hospitalized in Cayenne Hospital during the 2014-2015 outbreak.METHODS:We performed a preliminary retrospective study followed by a prospective study from March 2014 to February 2015. All infants younger than 3 months presenting with fever and hospitalized in Cayenne Hospital were included. The main diagnostic criteria were fever and positive Chikungunya PCR.RESULTS:One hundred and twenty infants were hospitalized with fever. The mean age was 46 days (SD± 22 days). The mean hospitalization duration was 7.4 days (SD± 6.1 days). Chikungunya infection was diagnosed in 26 children. The most important clinical findings were high (80.8% [77.5-84]) and prolonged fever (76.9%, [73.4-80.4]), irritability (96.2% [94.5-97.7]) and skin rash. (69.2%, [65.4-73]). Half of the infants presented edema of the extremities (hands and feet principally). However, in 15 %, Chikungunya infection was associated with a serious bacterial infection. Infants who presented with irritability, high fever and elevated PCT were at high risk for Chikungunya: OR 39, [9.2-243] (p < 0.001), with a specificity of 96.7 % and a negative predictive value of 89.4%. The area of the ROC curve was 0.96 CONCLUSIONS:: Our results confirm that Chikunguyna infection is a cause of high fever in infants younger than 3 months. Our data should be confirmed by larger studies.</description>
<date>2017-01-03</date>
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