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<title lang=en>Cytokines as molecular targets for aryl hydrocarbon receptor ligands: implications for toxicity and xenobiotic detoxification.</title>
<creator>FARDEL, Olivier</creator>
<contributor>Contaminants Chimiques, immunité et Inflammation ; Institut de recherche, santé, environnement et travail [Rennes] (Irset) ; Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ) - Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor>
<description>International audience</description>
<source>ISSN: 1742-5255</source>
<source>EISSN: 1744-7607</source>
<source>Expert Opinion on Drug Metabolism and Toxicology</source>
<publisher>Taylor & Francis</publisher>
<identifier>inserm-00831662</identifier>
<identifier>http://www.hal.inserm.fr/inserm-00831662</identifier>
<source>http://www.hal.inserm.fr/inserm-00831662</source>
<source>Expert Opinion on Drug Metabolism and Toxicology, Taylor & Francis, 2013, 9 (2), pp.141-52. 〈10.1517/17425255.2013.738194〉</source>
<identifier>DOI : 10.1517/17425255.2013.738194</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1517/17425255.2013.738194</relation>
<identifier>PUBMED : 23230817</identifier>
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<language>en</language>
<subject lang=en>aryl hydrocarbon receptor</subject>
<subject lang=en>chemokine</subject>
<subject lang=en>cytokine</subject>
<subject lang=en>drug detoxification</subject>
<subject lang=en>inflammation</subject>
<subject lang=en>interleukin</subject>
<subject lang=en>ligands</subject>
<subject>[SDV.TOX] Life Sciences [q-bio]/Toxicology</subject>
<subject>[SDV.SP] Life Sciences [q-bio]/Pharmaceutical sciences</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>INTRODUCTION: The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor historically known for regulating expression of several important drug-detoxifying proteins. Besides drug metabolism pathways, cytokines have been recently recognized as targeted by the AhR signaling cascade, which may contribute to toxicity and changes in xenobiotic detoxification caused by AhR agonists. AREAS COVERED: This article summarizes the nature of the main cytokines regulated by AhR ligands and reviews their involvement in toxic effects of AhR ligands, especially in relation with inflammation. The article also discusses the potential implications for drug detoxification pathways. EXPERT OPINION: Even if various cytokines, including inflammatory ones, have already been demonstrated to constitute robust targets for AhR, the exact role played by AhR with respect to inflammation remains to be determined. Further studies are also required to better characterize the molecular mechanisms implicated in regulation of cytokines by AhR ligands and to determine the role that may play AhR-targeted cytokines in alteration of xenobiotic detoxification. Finally, changes in cytokine receptor expression triggered by AhR ligands have additionally to be taken into account to better and more extensively comprehend the role played by AhR in the cytokine/inflammation area.</description>
<date>2013-02</date>
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