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<identifier>oai:HAL:hal-01579406v1</identifier>
<datestamp>2017-12-21</datestamp>
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<publisher>HAL CCSD</publisher>
<title lang=en>Comparaison des paramètres morphocinétiques du développement embryonnaire humain cultivé en milieu global ou en milieu séquentiel [Comparison of human embryomorphokinetic parameters in sequential or global culture media]</title>
<creator>Kazdar, Nadia</creator>
<creator>Brugnon, Florence</creator>
<creator>Bouche, Cyril</creator>
<creator>Jouve, Guilhem</creator>
<creator>Veau, Segolene</creator>
<creator>Drapier, Hortense</creator>
<creator>Rousseau, Chloé</creator>
<creator>Pimentel, Celine</creator>
<creator>Viard, Patricia</creator>
<creator>Belaud-Rotureau, Marc-Antoine</creator>
<creator>Ravel, Célia</creator>
<contributor>CHU Pontchaillou [Rennes]</contributor>
<contributor>Laboratoire BDR CECOS - FIV AMP ; CHU Estaing [Clermont-Ferrand]</contributor>
<contributor>Centre d'Investigation Clinique [Rennes] (CIC) ; Université de Rennes 1 (UR1) - Hôpital Pontchaillou - Institut National de la Santé et de la Recherche Médicale (INSERM)</contributor>
<contributor>Service de Gynécologie et Obstétrique [Rennes] ; Université de Rennes 1 (UR1) - CHU Pontchaillou [Rennes] - Hôpital Sud</contributor>
<contributor>Service de Cytogénétique et de Biologie Cellulaire ; Université de Rennes 1 (UR1) - Hôpital Pontchaillou - CHU Pontchaillou [Rennes]</contributor>
<contributor>Institut de recherche, santé, environnement et travail [Rennes] (Irset) ; Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor>
<description>International audience</description>
<source>Annales de Biologie Clinique</source>
<identifier>hal-01579406</identifier>
<identifier>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01579406</identifier>
<source>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01579406</source>
<source>Annales de Biologie Clinique, 2017, 75 (4), pp.403-410. 〈10.1684/abc.2017.1259〉</source>
<identifier>DOI : 10.1684/abc.2017.1259</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1684/abc.2017.1259</relation>
<identifier>PUBMED : 28751285</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/28751285</relation>
<language>fr</language>
<subject lang=en> sequential culture medium</subject>
<subject lang=en> Time-Lapse Imaging</subject>
<subject lang=en> human embryo</subject>
<subject lang=en> morphokinetics</subject>
<subject lang=en>global culture medium</subject>
<subject>[SDV] Life Sciences [q-bio]</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>A prospective study on randomized patients was conducted to determine how morphokinetic parameters are altered in embryos grown in sequential versus global culture media. Eleven morphokinetic parameters of 160 single embryos transferred were analyzed by time lapse imaging involving two University-affiliated in vitro fertilization (IVF) centers. We found that the fading of the two pronuclei occurred earlier in global (22.56±2.15 hpi) versus sequential media (23.63±2.71 hpi; p=0.0297). Likewise, the first cleavage started earlier at 24.52±2.33 hpi vs 25.76±2.95 hpi (p=0.0158). Also, the first cytokinesis was shorter in global medium, lasting 18±10.2 minutes in global versus 36±37.8 minutes in sequential culture medium (p <0.0001). We also observed a significant shortening in the duration of the 2-cell stage in sequential medium: 10.64 h±2.75 versus 11.66 h±1.11 in global medium (p=0.0225) which suggested a faster progression of the embryos through their first mitotic cell cycle. In conclusion, morphokinetic analysis of human embryos by Time lapse imaging reveals significant differences in five kinetic variables according to culture medium. Our study highlights the need to adapt morphokinetic analysis accordingly to the type of media used to best support human early embryo development.</description>
<date>2017</date>
</dc>
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