untitled
<OAI-PMH schemaLocation=http://www.openarchives.org/OAI/2.0/ http://www.openarchives.org/OAI/2.0/OAI-PMH.xsd>
<responseDate>2018-01-17T12:05:41Z</responseDate>
<request identifier=oai:HAL:hal-01584556v1 verb=GetRecord metadataPrefix=oai_dc>http://api.archives-ouvertes.fr/oai/hal/</request>
<GetRecord>
<record>
<header>
<identifier>oai:HAL:hal-01584556v1</identifier>
<datestamp>2018-01-11</datestamp>
<setSpec>type:ART</setSpec>
<setSpec>subject:sdv</setSpec>
<setSpec>collection:CNRS</setSpec>
<setSpec>collection:UNIV-AG</setSpec>
<setSpec>collection:UNIV-NC</setSpec>
<setSpec>collection:EHESS</setSpec>
<setSpec>collection:IFREMER</setSpec>
<setSpec>collection:IUEM</setSpec>
<setSpec>collection:ICSN</setSpec>
<setSpec>collection:EPHE</setSpec>
<setSpec>collection:THESES_IUEM</setSpec>
<setSpec>collection:UNIV-AMU</setSpec>
<setSpec>collection:LEMAR</setSpec>
<setSpec>collection:UNIV-POLYNESIE</setSpec>
<setSpec>collection:UNIV-BREST</setSpec>
<setSpec>collection:INC-CNRS</setSpec>
<setSpec>collection:PSL</setSpec>
<setSpec>collection:IN2P3</setSpec>
<setSpec>collection:CPPM</setSpec>
<setSpec>collection:UPF</setSpec>
<setSpec>collection:CMM</setSpec>
</header>
<metadata><dc>
<publisher>HAL CCSD</publisher>
<title lang=en>Cytotoxic guanidine alkaloids from the French Polynesian sponge Monanchora n. sp.</title>
<creator>Al-Mourabit, A</creator>
<creator>El-Demerdash, A</creator>
<creator>Moriou, C</creator>
<creator>Martin, M-T</creator>
<creator>Rodrigues-Stien, A</creator>
<creator>Petek, S</creator>
<creator>Demoy-Schneider, M</creator>
<creator>Hall, K</creator>
<creator>Hooper, J</creator>
<creator>Debitus, C.</creator>
<contributor>Institut de Chimie des Substances Naturelles (ICSN) ; Centre National de la Recherche Scientifique (CNRS)</contributor>
<contributor>Centre de Physique des Particules de Marseille (CPPM) ; Centre National de la Recherche Scientifique (CNRS) - Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3) - Aix Marseille Université (AMU)</contributor>
<contributor>Laboratoire des Sciences de l'Environnement Marin (LEMAR) (LEMAR) ; Centre National de la Recherche Scientifique (CNRS) - Université de Brest (UBO) - Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER) - Institut Universitaire Européen de la Mer (IUEM) ; Centre National de la Recherche Scientifique (CNRS) - Institut de Recherche pour le Développement (IRD) - Université de Brest (UBO) - Centre National de la Recherche Scientifique (CNRS) - Institut de Recherche pour le Développement (IRD) - Université de Brest (UBO) - Institut de Recherche pour le Développement (IRD)</contributor>
<contributor>University of French Polynesia</contributor>
<contributor>University of Calgary</contributor>
<contributor>Laboratoire d'Excellence CORAIL (LabEX CORAIL) ; Institut de Recherche pour le Développement (IRD) - Université des Antilles et de la Guyane (UAG) - École des hautes études en sciences sociales (EHESS) - École pratique des hautes études (EPHE) - Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER) - Université de la Réunion (UR) - Université de la Polynésie Française (UPF) - Université de Nouvelle Calédonie - Institut d'écologie et environnement</contributor>
<description>International audience</description>
<source>ISSN: 0163-3864</source>
<source>EISSN: 1520-6025</source>
<source>Journal of Natural Products</source>
<publisher>American Chemical Society</publisher>
<identifier>hal-01584556</identifier>
<identifier>https://hal.archives-ouvertes.fr/hal-01584556</identifier>
<source>https://hal.archives-ouvertes.fr/hal-01584556</source>
<source>Journal of Natural Products, American Chemical Society, 2016, p. 1929-1937. 〈http://pubs.acs.org/journal/jnprdf〉. 〈10.1021/acs.jnatprod.6b00168〉</source>
<identifier>DOI : 10.1021/acs.jnatprod.6b00168</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1021/acs.jnatprod.6b00168</relation>
<source>http://pubs.acs.org/journal/jnprdf</source>
<language>en</language>
<subject lang=en>MARINE NATURAL-PRODUCTS</subject>
<subject lang=en>CRAMBE-CRAMBE</subject>
<subject lang=en>PTILOMYCALIN-A</subject>
<subject lang=en>PULCHRA</subject>
<subject lang=en>CRAMBESCIDINS</subject>
<subject lang=en>SPICULIFER</subject>
<subject lang=en>CHEMISTRY</subject>
<subject lang=en>ARBUSCULA</subject>
<subject lang=en>FUSION</subject>
<subject lang=en>FRENCH POLYNESIA</subject>
<subject lang=fr>PRODUITS NATURELS MARINS</subject>
<subject lang=fr>CHIMIE</subject>
<subject lang=fr>EPONGES</subject>
<subject lang=fr>POLYNESIE FRANCAISE</subject>
<subject>[SDV.BV] Life Sciences [q-bio]/Vegetal Biology</subject>
<subject>[SDV.SP.PHARMA] Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>Four bicyclic and three pentacyclic guanidine alkaloids (1–7) were isolated from a French Polynesian Monanchora n. sp. sponge, along with the known alkaloids monalidine A (8), enantiomers 9–11 of known natural product crambescins, and the known crambescidins 12–15. Structures were assigned by spectroscopic data interpretation. The relative and absolute configurations of the alkaloids were established by analysis of 1H NMR and NOESY spectra and by circular dichroism analysis. The new norcrambescidic acid (7) corresponds to interesting biosynthetic variation within the pentacyclic core. All compounds exhibited antiproliferative and cytotoxic efficacy against KB, HCT116, HL60, MRC5, and B16F10 cancer cells, with IC50 values ranging from 4 nM to 10 μM.</description>
<date>2016-07</date>
</dc>
</metadata>
</record>
</GetRecord>
</OAI-PMH>
