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<title lang=en>Chlordecone exposure, length of gestation, and risk of preterm birth.</title>
<creator>Kadhel, Philippe</creator>
<creator>Monfort, Christine</creator>
<creator>Costet, Nathalie</creator>
<creator>Rouget, Florence</creator>
<creator>Thomé, Jean-Pierre</creator>
<creator>Multigner, Luc</creator>
<creator>Cordier, Sylvaine</creator>
<contributor>Institut de recherche, santé, environnement et travail [Rennes] (Irset) ; Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor>
<contributor>Laboratory of Animal Ecology and Ecotoxicology ; Université de Liège</contributor>
<contributor>INSERM; Agence Nationale de la Recherche; Agence Francaise de Securite Sanitaire de l'Environnement et du Travail; Programme National de Recherche sur les Perturbateurs Endocriniens of the French Ministry of Environment; Direction Generale de la Sante; Institut de Veille Sanitaire</contributor>
<description>International audience</description>
<source>ISSN: 0002-9262</source>
<source>EISSN: 1476-6256</source>
<source>American Journal of Epidemiology</source>
<publisher>Oxford University Press (OUP)</publisher>
<identifier>hal-01010740</identifier>
<identifier>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01010740</identifier>
<identifier>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01010740/document</identifier>
<identifier>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01010740/file/Chlordecone%20Exposure%20final.pdf</identifier>
<source>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01010740</source>
<source>American Journal of Epidemiology, Oxford University Press (OUP), 2014, 179 (5), pp.536-544. 〈10.1093/aje/kwt313〉</source>
<identifier>DOI : 10.1093/aje/kwt313</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1093/aje/kwt313</relation>
<identifier>PUBMED : 24401561</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/24401561</relation>
<language>en</language>
<subject lang=en>preterm birth</subject>
<subject lang=en>pesticides</subject>
<subject lang=en>chlordecone</subject>
<subject lang=en>French West Indies</subject>
<subject lang=en>length of gestation</subject>
<subject lang=en>persistent organic pollutants</subject>
<subject>[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>Persistent organic pollutants have not been conclusively associated with length of gestation or with preterm birth. Chlordecone is an organochlorine pesticide that has been extensively used to control the banana root borer population in the French West Indies. Data from the Timoun Mother-Child Cohort Study conducted in Guadeloupe between 2004 and 2007 were used to examine the associations of chlordecone concentrations in maternal plasma with the length of gestation and the rate preterm birth in 818 pregnant women. Data were analyzed using multivariate linear regression for length of gestation and a Cox model for preterm birth. The median plasma chlordecone concentration was 0.39 µg/L (interquartile range, 0.18-0.83). No correlation was observed with plasma concentrations of p,p'-dichlorodiphenyl dichloroethene (ρ = 0.017) or polychlorinated biphenyl 153 (ρ = -0.016), the other main organochlorine compounds detected. A 1-log10 increase in chlordecone concentration was associated with a decreased length of gestation (-0.27 weeks; 95% confidence interval: -0.50, -0.03) and an increased risk of preterm birth (60%; 95% confidence interval: 10, 130). These associations may result from the estrogen-like and progestin-like properties of chlordecone. These results are of public health relevance because of the prolonged persistence of chlordecone in the environment and the high background rate of preterm births in this population.</description>
<date>2014</date>
</dc>
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