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<title lang=en>Cytoplasmic cyclin D1 controls the migration and invasiveness of mantle lymphoma cells</title>
<creator>Body, Simon</creator>
<creator>Esteve-Arenys, Anna</creator>
<creator>Miloudi, Hadjer</creator>
<creator>Recasens-Zorzo, Clara</creator>
<creator>Tchakarska, Guergana</creator>
<creator>Moros, Alexandra</creator>
<creator>Bustany, Sophie</creator>
<creator>Vidal-Crespo, Anna</creator>
<creator>Rodriguez, Vanina</creator>
<creator>Lavigne, Régis</creator>
<creator>Com, Emmanuelle</creator>
<creator>Casanova, Isolda</creator>
<creator>Mangues, Ramón</creator>
<creator>Weigert, Oliver</creator>
<creator>Sanjuan-Pla, Alejandra</creator>
<creator>Menéndez, Pablo</creator>
<creator>Marcq, Bénédicte</creator>
<creator>Picquenot, Jean-Michel</creator>
<creator>Pérez-Galán, Patricia</creator>
<creator>Jardin, Fabrice</creator>
<creator>Roué, Gaël</creator>
<creator>Sola, Brigitte</creator>
<contributor>Groupe de Recherche en Psychologie Sociale (GRePS) ; Université Lumière - Lyon 2 (UL2)</contributor>
<contributor>UNICAEN ; Institut de Recherche pour le Développement (IRD [ Madagascar])</contributor>
<contributor>Plateforme Protéomique-Biogenouest (PPB) ; Institut de recherche, santé, environnement et travail [Rennes] (Irset) ; Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ) - Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ) - Proteomics Core Facility (Protim) ; Université de Rennes 1 (UR1) - Plateforme Génomique Santé Biogenouest® - Plateforme Génomique Santé Biogenouest®</contributor>
<contributor>Institut de recherche, santé, environnement et travail [Rennes] (Irset) ; Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor>
<contributor>service d'anatomo-pathologie ; CRLCC Henri Becquerel</contributor>
<contributor>Service hématologie ; CRLCC Henri Becquerel</contributor>
<contributor>Apoptose et Système Immunitaire (ASI) ; Institut Pasteur [Paris] - Centre National de la Recherche Scientifique (CNRS)</contributor>
<description>International audience</description>
<source>ISSN: 2045-2322</source>
<source>EISSN: 2045-2322</source>
<source>Scientific Reports</source>
<publisher>Nature Publishing Group</publisher>
<identifier>hal-01635754</identifier>
<identifier>https://hal.archives-ouvertes.fr/hal-01635754</identifier>
<source>https://hal.archives-ouvertes.fr/hal-01635754</source>
<source>Scientific Reports, Nature Publishing Group, 2017, 7 (1), pp.13946. 〈10.1038/s41598-017-14222-1〉</source>
<identifier>DOI : 10.1038/s41598-017-14222-1</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1038/s41598-017-14222-1</relation>
<identifier>PUBMED : 29066743</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/29066743</relation>
<language>en</language>
<subject>[SDV.CAN] Life Sciences [q-bio]/Cancer</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>Mantle cell lymphoma (MCL) is a hematologic neoplasm characterised by the t(11;14)(q13;q32) translocation leading to aberrant cyclin D1 expression. The cell functions of cyclin D1 depend on its partners and/or subcellular distribution, resulting in different oncogenic properties. We observed the accumulation of cyclin D1 in the cytoplasm of a subset of MCL cell lines and primary cells. In primary cells, this cytoplasmic distribution was correlated with a more frequent blastoid phenotype. We performed immunoprecipitation assays and mass spectrometry on enriched cytosolic fractions from two cell lines. The cyclin D1 interactome was found to include several factors involved in adhesion, migration and invasion. We found that the accumulation of cyclin D1 in the cytoplasm was associated with higher levels of migration and invasiveness. We also showed that MCL cells with high cytoplasmic levels of cyclin D1 engrafted more rapidly into the bone marrow, spleen, and brain in immunodeficient mice. Both migration and invasion processes, both in vivo and in vitro, were counteracted by the exportin 1 inhibitor KPT-330, which retains cyclin D1 in the nucleus. Our data reveal a role of cytoplasmic cyclin D1 in the control of MCL cell migration and invasion, and as a true operator of MCL pathogenesis.</description>
<date>2017-12</date>
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